Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Serge Auvin"'
Autor:
David P. Lane, Dilraj Lama, Christopher J. Brown, Serge Auvin, Tarig Bashir, Chandra S. Verma, Jessica Nakhle, Natia Tsomaia, Yuri Frosi, Anne-Marie Liberatore
Publikováno v:
'Chemical Science ', vol: 10, pages: 2489-2500 (2019)
Stapled-peptides have emerged as an exciting class of molecules which can modulate protein–protein interactions. We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high binding affinities and r
Autor:
Tarig Bashir, Harun Öztürk, Florence Meyer-Losic, Gisele Mautino, Florence Jollivet, Serge Auvin, Umut Sahin, Yusuf T Abaci
Publikováno v:
Life Science Alliance
A new molecule induces AR sumoylation and degradation resulting in selective growth inhibition in AR-dependent prostate cancer cells, but its activity is blunted by interference with proteasomes.
Aberrant androgen signaling drives prostate cance
Aberrant androgen signaling drives prostate cance
Publikováno v:
Journal of Neurochemistry. 98:1217-1228
Cell death is a common feature observed in neurodegenerative disorders, and is often associated with calpain activation and overproduction of reactive oxygen species (ROS). This study investigated the use of calpain inhibitors and antioxidants in com
Autor:
Pierre-E. Chabrier, Serge Auvin, Bernadette Pignol, Dennis Bigg, Denis Carré, Morgane Troadec, José Camara, Edith Navet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1586-1589
A series of dipeptides with dual inhibitory activities on calpain and lipid peroxidation were prepared to target the intracellular calpain. This optimization program focused on the variations of the linker and the N-terminal amino acid of the peptidi
Autor:
Pierre-E. Chabrier, Dennis Bigg, Eric Ferrandis, Christine Dolo, Michel Auguet, Florence Auger, Isabelle Viossat, Serge Auvin, Jeremiah Harnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(1)
Novel azole compounds were prepared which demonstrated potent hCB2 binding activities with antioxidant activity for a selected compound. These compounds show good selectivity over the hCB1 receptor and are full agonists at the hCB2 receptor.
Autor:
Isabelle Viossat, Brigitte Spinnewyn, Salvador Moncada, Dennis Bigg, Sylvie Cornet, Jocelyne Schulz, Michel Auguet, Caroline Demerlé-Pallardy, Bernadette Pignol, P. E. Chabrier, Christine Guilmard-Favre, Véronique Gillard-Roubert, Serge Auvin, Jean-Gregoire Marin, Christelle Roussillot-Charnet
Publikováno v:
Proceedings of the National Academy of Sciences. 96:10824-10829
Nitric oxide (NO) and reactive oxygen species (ROS) act independently as well as cooperatively to induce neuronal death in acute neurological disorders. Inhibition of neuronal nitric oxide synthase (nNOS) and inhibition of lipid peroxidation induced
Publikováno v:
Bioorganic Chemistry. 19:143-151
The design, synthesis and evaluation of potential affinity labels of Escherichia coli glucosamine-6-phosphate synthase (glmS) are described. Among the inhibitors described, 2-amino-3-(( N -halomethyl)amino)propanoates 1a and 2a and 2-amino-3-( N -mal
Autor:
Pierre Etienne Chabrier, Serge Auvin, Edith Navet, Dennis Bigg, Isabelle Viossat, Jocelyne Schulz, Michel Auguet, Jeremiah Harnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(2)
A series of hybrid compounds possessing an nNOS pharmacophore linked to an antioxidant fragment has been synthesized. Among them, compound 8d, a propofol derivative, displayed the greatest dual potencies against nNOS (IC(50)=0.12 microM) and lipid pe
Publikováno v:
Neuromuscular Disorders. 17:801