Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [18F]ICF01006, a highly promising melanoma PET tracer

Autor: Elisabeth Miot-Noirault, Aurélien Vidal, Philippe Auzeloux, Florent Cachin, Jean-Michel Chezal, Latifa Rbah-Vidal, Mathilde Bonnet, Serge Askienazy, Frédéric Dollé, Sophie Besse, Nicole Moins, Françoise Degoul, Laurent Audin

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 39:1449-1461

Purpose Here, we report a new and rapid radiosynthesis of 18F-N-[2-(diethylamino)ethyl]-6-fluoro-pyridine-3-carboxamide ([18F]ICF01006), a molecule with a high specificity for melanotic tissue, and its evaluation in a murine model for early specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e328b6a71766db46bf9ce8806c2fa629
https://doi.org/10.1007/s00259-012-2168-y

Psychogenic parkinsonism: A combination of clinical, electrophysiological, and [123I]-FP-CIT SPECT scan explorations improves diagnostic accuracy

Autor: Philippe Remy, Paolo Zanotti Fregonara, Sandrine Benaderette, Charles Nguyen, Marie Vidailhet, Serge Askienazy, Jean Marc Trocello, Emmanuelle Apartis, Jean Yves Devaux

Publikováno v: Movement Disorders. 21:310-317

We evaluated the concordance between independent clinical, electrophysiological, and [123I]-FP-CIT SPECT scan explorations as a staged procedure for an accurate diagnosis in 9 patients referred with a diagnosis of suspected psychogenic parkinsonism.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ad54a2097966fb7f7db62338d645dbe
https://doi.org/10.1002/mds.20720

Synthesis, Radiofluorination, and in Vivo Evaluation of Novel Fluorinated and Iodinated Radiotracers for PET Imaging and Targeted Radionuclide Therapy of Melanoma

Autor: Philippe Auzeloux, Jean-Michel Chezal, Jean-Claude Madelmont, Elisabeth Miot-Noirault, Emilie M. F. Billaud, Sébastien Tarrit, Sophie Besse, Latifa Rbah-Vidal, Serge Askienazy, Nicole Moins, Aurélien Vidal, Aurélie Maisonial

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2013, 56 (21), pp.8455-8467. ⟨10.1021/jm400877v⟩
Journal of Medicinal Chemistry, American Chemical Society, 2013, 56 (21), pp.8455-8467. ⟨10.1021/jm400877v⟩

Our project deals with a multimodal approach using a single fluorinated and iodinated melanin-targeting structure and offering both imaging (positron emission tomography (PET)/fluorine-18) and treatment (targeted radionuclide therapy/iodine-131) of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b087e6d9ce43dde41f3d1abc66c1fc
https://hal.science/hal-01677595

Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer

Autor: Latifa, Rbah-Vidal, Aurélien, Vidal, Sophie, Besse, Florent, Cachin, Mathilde, Bonnet, Laurent, Audin, Serge, Askienazy, Frédéric, Dollé, Françoise, Degoul, Elisabeth, Miot-Noirault, Nicole, Moins, Philippe, Auzeloux, Jean-Michel, Chezal

Publikováno v: European journal of nuclear medicine and molecular imaging. 39(9)

Here, we report a new and rapid radiosynthesis of (18)F-N-[2-(diethylamino)ethyl]-6-fluoro-pyridine-3-carboxamide ([(18)F]ICF01006), a molecule with a high specificity for melanotic tissue, and its evaluation in a murine model for early specific dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd558c6e9894e3943be8fd0e67e2ba71
https://pubmed.ncbi.nlm.nih.gov/22707183

Single Photon Emission Computed Tomography/Positron Emission Tomography Imaging and Targeted Radionuclide Therapy of Melanoma: New Multimodal Fluorinated and Iodinated Radiotracers

Autor: Philippe Auzeloux, Aurélien Vidal, Jean-Claude Madelmont, Jean-Michel Chezal, Raphaël Boisgard, Marie-Josèphe Galmier, Michèle Borel, Elisabeth Miot-Noirault, Aurélie Maisonial, Serge Askienazy, Mathilde Bonnet-Duquennoy, Bertrand Kuhnast, Bertrand Tavitian, Nicole Moins, Janine Papon, Martine Bayle, Frédéric Dollé, Latifa Rbah

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2011, 54 (8), pp.2745-2766. ⟨10.1021/jm101574q⟩
Journal of Medicinal Chemistry, American Chemical Society, 2011, 54 (8), pp.2745-2766. ⟨10.1021/jm101574q⟩

This study reports a series of 14 new iodinated and fluorinated compounds offering both early imaging ((123)I, (124)I, (18)F) and systemic treatment ((131)I) of melanoma potentialities. The biodistribution of each (125)I-labeled tracer was evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca145557e32de3cc79faf260ddfcec7
https://hal.science/hal-01677589