Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Serge A. Y. Afeli"'
Autor:
Kiril L Hristov, Serge A Y Afeli, Shankar P Parajuli, Qiuping Cheng, Eric S Rovner, Georgi V Petkov
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68052 (2013)
Patients suffering from a variety of neurological diseases such as spinal cord injury, Parkinson's disease, and multiple sclerosis often develop neurogenic detrusor overactivity (NDO), which currently lacks a universally effective therapy. Here, we t
Externí odkaz:
https://doaj.org/article/3b036dc0e57e46bea377384bc04de2e0
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75875 (2013)
Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expres
Externí odkaz:
https://doaj.org/article/841000e8948b418b863d2d61a445791c
Publikováno v:
American Journal of Physiology-Renal Physiology. 303:F559-F568
Animal studies suggest that the small (SK) and intermediate (IK) conductance Ca2+-activated K+channels may contribute to detrusor smooth muscle (DSM) excitability and contractility. However, the ability of SK and IK channels to control DSM spontaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf3e38fbcd0c8b45720e41db24800c1
https://doi.org/10.1152/ajprenal.00615.2011
https://doi.org/10.1152/ajprenal.00615.2011
Autor:
Georgi V. Petkov, Kiril L. Hristov, Serge A. Y. Afeli, Muyan Chen, Eric S. Rovner, Qiuping Cheng
Publikováno v:
American Journal of Physiology-Cell Physiology. 302:C1599-C1608
The functional role of the voltage-gated K+ (KV) channels in human detrusor smooth muscle (DSM) is largely unexplored. Here, we provide molecular, electrophysiological, and functional evidence for the expression of KV2.1, KV2.2, and the electrically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bb94cfddc5f8fdfb4fd186635c6b80
https://doi.org/10.1152/ajpcell.00447.2011
https://doi.org/10.1152/ajpcell.00447.2011
Publikováno v:
American journal of physiology. Cell physiology. 306(1)
Mechanisms underlying ethanol (EtOH)-induced detrusor smooth muscle (DSM) relaxation and increased urinary bladder capacity remain unknown. We investigated whether the large conductance Ca2+-activated K+ (BK) channels or L-type voltage-dependent Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6e87677aebb995f02f5b9725ce236a
https://pubmed.ncbi.nlm.nih.gov/24153429
https://pubmed.ncbi.nlm.nih.gov/24153429
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75875 (2013)
PLoS ONE, Vol 8, Iss 9, p e75875 (2013)
Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29777d9563464fbacbc8dcdd8347a6dd
http://europepmc.org/articles/PMC3779188
http://europepmc.org/articles/PMC3779188
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c54a0a90268799529ec6c6992ff7951e
https://doi.org/10.1096/fasebj.27.1_supplement.923.8
https://doi.org/10.1096/fasebj.27.1_supplement.923.8
Autor:
Serge A. Y. Afeli, Georgi V. Petkov
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b756f16817e1e92b0da38603eae2a34
https://doi.org/10.1096/fasebj.27.1_supplement.923.14
https://doi.org/10.1096/fasebj.27.1_supplement.923.14
Autor:
Georgi V. Petkov, Serge A. Y. Afeli
Publikováno v:
European journal of pharmacology. 711(1-3)
The large-conductance voltage- and Ca2+-activated K+ (BK) channel is a major regulator of detrusor smooth muscle (DSM) contractility thus facilitating urinary bladder function. Recent findings suggest that activation of β3-adrenoceptors causes DSM r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89d150de99a45f5d925b67d246597cf
https://pubmed.ncbi.nlm.nih.gov/23643998
https://pubmed.ncbi.nlm.nih.gov/23643998
Autor:
Rupal P. Soder, Qiuping Cheng, Wenkuan Xin, Georgi V. Petkov, Kiril L. Hristov, Scott Earley, Serge A. Y. Afeli, Amy C. Smith, Shankar P. Parajuli, John Malysz
The TRPM4 channel is a Ca2+-activated, monovalent cation-selective channel of the melastatin transient receptor potential (TRPM) family. The TRPM4 channel is implicated in the regulation of many cellular processes including the immune response, insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9356e4330ccc2be543776c217237acb
https://europepmc.org/articles/PMC3625855/
https://europepmc.org/articles/PMC3625855/
