Ultrasound-Mediated Blood-Brain Barrier Opening Improves Whole Brain Gene Delivery in Mice

Autor: Marie-Solenne Felix, Emilie Borloz, Khaled Metwally, Ambre Dauba, Benoit Larrat, Valerie Matagne, Yann Ehinger, Laurent Villard, Anthony Novell, Serge Mensah, Jean-Christophe Roux

Publikováno v: Pharmaceutics, Vol 13, Iss 8, p 1245 (2021)

Gene therapy represents a powerful therapeutic tool to treat diseased tissues and provide a durable and effective correction. The central nervous system (CNS) is the target of many gene therapy protocols, but its high complexity makes it one of the m

Externí odkaz: https://doaj.org/article/9ae232de04cf41178cf94772dee6a02c

Tunable microbubble generator using electrolysis and ultrasound

Autor: Younes Achaoui, Khaled Metwally, Damien Fouan, Zoubida Hammadi, Roger Morin, Eric Debieu, Cédric Payan, Serge Mensah

Publikováno v: AIP Advances, Vol 7, Iss 1, Pp 015011-015011-7 (2017)

This letter reports on a method for producing on demand calibrated bubbles in a non-chemically controlled solution using localized micro-electrolysis and ultrasound. Implementing a feedback loop in the process leads to a point source of stable mono-d

Externí odkaz: https://doaj.org/article/15905dfdffa54827bc2dd05495a9eaeb

Acoustical characterisation and monitoring of microbubble clouds

Autor: Serge Mensah, Lilian D'Hondt, Cédric Payan, Matthieu Cavaro

Publikováno v: Ultrasonics
Ultrasonics, Elsevier, 2019, ⟨10.1016/j.ultras.2019.03.009⟩
Ultrasonics, 2019, ⟨10.1016/j.ultras.2019.03.009⟩

International audience; Argon microbubbles will exist in the primary sodium of the next generation of sodium-cooled fast reactors (SFR). Due to its opacity, acoustic methods will be used for the in-service inspection in these reactors, but the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2423117074e61155856f03edd93233d1
https://doi.org/10.1016/j.ultras.2019.03.009

Development of a multi-functional preclinical device for the treatment of glioblastoma

Autor: Khaled Metwally, Anabela Da Silva, Benoit Larrat, Samantha Fernandez, Serge Mensah, Marie-Anne Esteve, Benjamin Guillet, Florian Correard, Anthony Novell, Chiara Bastiancich

Publikováno v: Biomed Opt Express
Biomedical optics express
Biomedical optics express, 2021, 12 (4), pp.2264-2279. ⟨10.1364/boe.419412⟩
Biomedical optics express, Optical Society of America-OSA Publishing, 2021, 12 (4), pp.2264. ⟨10.1364/BOE.419412⟩
Biomedical optics express, Optical Society of America-OSA Publishing, 2021, 12 (4), pp.2264-2279. ⟨10.1364/boe.419412⟩

Glioblastoma multiforme (GBM) is one of the most common and aggressive malignant primary brain tumors in adults. The treatment of GBM is limited by the blood-brain barrier (BBB), which limits the diffusion of appropriate concentrations of therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d26951c12761aebc5bf328f1ef250c
https://europepmc.org/articles/PMC8086436/

Weld inspection by focused adjoint method

Autor: Emma Lubeigt, Serge Mensah, Gilles Gobillot, Khaled Metwally, Jean-François Chaix, François Baqué, Sandrine T. Rakotonarivo

Publikováno v: Ultrasonics
Ultrasonics, Elsevier, 2018, 83, pp.80-87. ⟨10.1016/j.ultras.2017.08.009⟩
Ultrasonics, 2018, 83, pp.80-87. ⟨10.1016/j.ultras.2017.08.009⟩

This paper reports a methodology for the non-destructive ultrasonic evaluation of welds, based on probing, residue back-focusing and topological energy calculation using an enhanced (focused) adjoint method. The proposed method combines the advantage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fda4afcd6ff5e241f5e8ea91d56e05
https://doi.org/10.1016/j.ultras.2017.08.009