Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death

Autor: François Virard, Stéphane Giraud, Mélanie Bonnet, Léa Magadoux, Laetitia Martin, Thuy Ha Pham, Najwa Skafi, Sophie Deneuve, Rita Frem, Bruno O. Villoutreix, Nawal Hajj Sleiman, Jonathan Reboulet, Samir Merabet, Vincent Chaptal, Cédric Chaveroux, Nader Hussein, Nicolas Aznar, Tanguy Fenouil, Isabelle Treilleux, Pierre Saintigny, Stéphane Ansieau, Serge Manié, Serge Lebecque, Toufic Renno, Isabelle Coste

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract The quest for targeted therapies is critical in the battle against cancer. The RAS/MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous

Externí odkaz: https://doaj.org/article/5f91f695de8442caa6ead3b1243c6294

Data from Therapeutic Enhancement of ER Stress by Insulin-Like Growth Factor I Sensitizes Myeloma Cells to Proteasomal Inhibitors

Autor: Charles Dumontet, Serge Manié, Kamel Chettab, Anne-Laure Huber, Eva-Laure Matera, Stéphanie Herveau, Lars Petter Jordheim, Inès Tagoug

Purpose: Multiple myeloma is a clonal plasma cell disorder in which growth and proliferation are linked to a variety of growth factors, including insulin-like growth factor type I (IGF-I). Bortezomib, the first-in-class proteasome inhibitor, has disp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468cab445f5339e830e7545d438511e3
https://doi.org/10.1158/1078-0432.c.6522021

A Gender-Dependent Molecular Switch of Inflammation via MyD88/Estrogen Receptor-Alpha Interaction

Autor: Alain Kfoury, Isabelle Coste, Muriel Le Romancer, Melanie Bonnet, François Virard, Isabelle Treilleux, Kevin Lang, Serge Manié, Toufic Renno, Bassam Badran, Serge Lebecque, Rana El Sabeh, Nader Hussein, Katy Le Corf

Publikováno v: Journal of Inflammation Research
Journal of Inflammation Research, 2021, 14, pp.2149-2156. ⟨10.2147/JIR.S306805⟩
Journal of Inflammation Research, Dove Medical Press, 2021, Volume 14, pp.2149-2156. ⟨10.2147/JIR.S306805⟩

Rana El Sabeh,1,2 Mélanie Bonnet,1 Katy Le Corf,1 Kevin Lang,1 Alain Kfoury,1 Bassam Badran,2 Nader Hussein,2 Francois Virard,1 Isabelle Treilleux,3 Muriel Le Romancer,1 Serge Lebecque,1 Serge Manie,1 Isabelle Coste,1,* Toufic Renno1,* 1Université

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932fdfa6a72da7f8504648a5e629de0b
https://www.dovepress.com/a-gender-dependent-molecular-switch-of-inflammation-via-myd88estrogen--peer-reviewed-fulltext-article-JIR

Addicted to secrete – novel concepts and targets in cancer therapy

Autor: Eric Chevet, Nicolas Dejeans, Ted R. Hupp, Serge Manié, Afshin Samali, Frederic Bard, Claudio Hetz, Patrizia Agostinis

Publikováno v: TRENDS IN MOLECULAR MEDICINE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic potential of targeting the U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffd097a11d1ad74b7f8eede06971104
https://doi.org/10.1016/j.molmed.2013.12.003

MyD88 in DNA Repair and Cancer Cell Resistance to Genotoxic Drugs

Autor: Isabelle Coste, Alain Kfoury, Toufic Renno, Rana El Sabeh, Serge Lebecque, Katy Le Corf, Serge Manié, Alexandra Journeaux, Bassam Badran, Nader Hussein

Publikováno v: JNCI: Journal of the National Cancer Institute
JNCI: Journal of the National Cancer Institute, Oxford University Press (OUP), 2013, 105 (13), pp.937-946. ⟨10.1093/jnci/djt120⟩

To ensure recognition of a broad variety of pathogens, the innate immune system has evolved, through a number of receptors, a strategy to recognize a limited number of conserved pathogen-associated molecular patterns. These receptors include the Toll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15ebd9d571e44cea314405cd27ce0bb
https://doi.org/10.1093/jnci/djt120