Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis.

Autor: Kostel Bal S; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Giuliani S; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Block J; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Repiscak P; St. Anna Children's Cancer Research Institute, Vienna, Austria., Hafemeister C; St. Anna Children's Cancer Research Institute, Vienna, Austria., Shahin T; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kasap N; Department of Pediatrics, Division of Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey., Ransmayr B; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Miao Y; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., van de Wetering C; St. Anna Children's Cancer Research Institute, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Frohne A; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Jimenez Heredia R; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Schuster M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Zoghi S; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Hertlein V; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Thian M; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Bykov A; St. Anna Children's Cancer Research Institute, Vienna, Austria., Babayeva R; Department of Pediatrics, Division of Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey., Bilgic Eltan S; Department of Pediatrics, Division of Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey., Karakoc-Aydiner E; Department of Pediatrics, Division of Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey., Shaw LE; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Chowdhury I; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Varjosalo M; Institute of Biotechnology, University of Helsinki, Helsinki, Finland., Argüello RJ; Aix Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France., Farlik M; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Ozen A; Department of Pediatrics, Division of Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey., Serfling E; Department of Molecular Pathology, Institute of Pathology, and Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany., Dupré L; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; Department of Dermatology, Medical University of Vienna, Vienna, Austria.; Toulouse Institute for Infectious and Inflammatory Diseases, INSERM, CNRS, Toulouse III Paul Sabatier University, Toulouse, France., Bock C; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Medical University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science, Vienna, Austria., Halbritter F; St. Anna Children's Cancer Research Institute, Vienna, Austria., Hannich JT; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Castanon I; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Kraakman MJ; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria., Baris S; Department of Pediatrics, Division of Allergy and Immunology, Marmara University School of Medicine, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Marmara University, Istanbul, Turkey., Boztug K; St. Anna Children's Cancer Research Institute, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; St. Anna Children's Hospital, Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Publikováno v: Blood [Blood] 2023 Aug 31; Vol. 142 (9), pp. 827-845.

NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation.

Autor: Giampaolo S; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany., Chiarolla CM; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany., Knöpper K; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-University Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany., Vaeth M; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-University Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany., Klein M; Institute for Immunology, University Medical Center, University of Mainz, Langenbeckstraße 1, 55131 Mainz, Germany., Muhammad A; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany., Bopp T; Institute for Immunology, University Medical Center, University of Mainz, Langenbeckstraße 1, 55131 Mainz, Germany., Berberich-Siebelt F; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany., Patra AK; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.; Peninsula Medical School, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK., Serfling E; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, Würzburg, Germany., Klein-Hessling S; Institute of Pathology, Julius Maximilians University Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.

Publikováno v: IScience [iScience] 2023 Feb 19; Vol. 26 (3), pp. 106234. Date of Electronic Publication: 2023 Feb 19 (Print Publication: 2023).

SUMOylation of the transcription factor NFATc1 leads to its subnuclear relocalization and IL2 repression by HDAC

Autor: Berberich-Siebelt F, Serfling E, Schmitt E, Buttmann M, Bopp T, Vaeth M, Glöckner-Pagel J, Nayak A

Publikováno v: Cell Communication and Signaling, Vol 7, Iss Suppl 1, p A7 (2009)

Externí odkaz: https://doaj.org/article/78290bf055dd47889c3ac76a50b369f3

Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1.

Autor: Barahona de Brito C; Peninsula Medical School, University of Plymouth, Plymouth PL6 8BU, UK.; Department of Biology and Biochemistry, University of Bath, Bath BA2 7AX, UK., Klein-Hessling S; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Josef Schneider-Str. 2, 97080 Wuerzburg, Germany., Serfling E; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Josef Schneider-Str. 2, 97080 Wuerzburg, Germany.; Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Josef Schneider-Str. 6, 97080 Wuerzburg, Germany., Patra AK; Peninsula Medical School, University of Plymouth, Plymouth PL6 8BU, UK.

Publikováno v: Cells [Cells] 2022 Jun 23; Vol. 11 (13). Date of Electronic Publication: 2022 Jun 23.

NFAT5 Controls the Integrity of Epidermis.

Autor: Muhammad K; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Xavier D; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Klein-Hessling S; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany.; Comprehensive Cancer Centre Mainfranken, Wuerzburg, Germany., Azeem M; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany.; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Wuerzburg, Germany., Rauschenberger T; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Murti K; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Avots A; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany.; Comprehensive Cancer Centre Mainfranken, Wuerzburg, Germany., Goebeler M; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Wuerzburg, Germany., Klein M; Institute for Immunology, University Medical Center, University of Mainz, Mainz, Germany., Bopp T; Institute for Immunology, University Medical Center, University of Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center, University of Mainz, Mainz, Germany.; University Cancer Center Mainz, University Medical Center, University of Mainz, Mainz, Germany., Sielaff M; Institute for Immunology, University Medical Center, University of Mainz, Mainz, Germany., Tenzer S; Institute for Immunology, University Medical Center, University of Mainz, Mainz, Germany., Möckel S; Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Aramburu J; Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain., López-Rodríguez C; Immunology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain., Kerstan A; Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Wuerzburg, Germany., Serfling E; Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany.; Comprehensive Cancer Centre Mainfranken, Wuerzburg, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Dec 09; Vol. 12, pp. 780727. Date of Electronic Publication: 2021 Dec 09 (Print Publication: 2021).