A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

Autor: Maher, Steven P, Bakowski, Malina A, Vantaux, Amelie, Flannery, Erika L, Andolina, Chiara, Gupta, Mohit, Antonova-Koch, Yevgeniya, Argomaniz, Magdalena, Monica, Cabrera-Mora, Brice, Campo, Chao, Alexander T, Chatterjee, Arnab K, Cheng, Wayne T, Cooper, Caitlin A, Karissa, Cottier, Galinski, Mary R, Harupa-Chung, Anke, Ji, Hana, Joseph, Sean B, Lenz, Todd, Lonardi, Stefano, Matheson, Jessica, Mikolajczak, Sebastian A, Padin-Irizarry, Vivian, Pan, Kastin, Peneau, Julie, Prudhomme, Jacques, Roesch, Camille, Ruberto, Anthony A, Sabnis, Saniya S, Saney, Celia L, Sattabongkot, Jetsumon, Sereshki, Saleh, Suriyakan, Sangrawee, Timothy, Moeller, Ubalee, Ratawan, Wang, Yinsheng, Wasisakun, Praphan, Yin, Jiekai, McNamara, Case W, Joyner, Chester J, Nosten, Francois, Witkowski, Benoit, Le Roch, Karine G, Kyle, Dennis E

Publikováno v: bioRxiv, vol 4, iss 02-10

Radical cure of Plasmodium vivax malaria must include elimination of quiescent "hypnozoite" forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug targets, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::441b5fbf9fbed4515faf0e35703b5388
https://escholarship.org/uc/item/5xg122bt

On the prediction of non-CG DNA methylation using machine learning.

Autor: Sereshki S; Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA., Lee N; Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA., Omirou M; Department of Agrobiotechnology, Agricultural Microbiology Laboratory, Agricultural Research Institute, Nicosia 1516, Cyprus., Fasoula D; Department of Plant Breeding, Agricultural Research Institute, Nicosia 1516, Cyprus., Lonardi S; Department of Computer Science and Engineering, University of California, Riverside, CA 92521, USA.

Publikováno v: NAR genomics and bioinformatics [NAR Genom Bioinform] 2023 May 17; Vol. 5 (2), pp. lqad045. Date of Electronic Publication: 2023 May 17 (Print Publication: 2023).