Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

Autor: Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Andrea Angeli, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Simona Distinto

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 685-692 (2021)

A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carboni

Externí odkaz: https://doaj.org/article/b4e1f0d1e7d5471eb96942409fad975f

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

Autor: Simona Distinto, Rita Meleddu, Francesco Ortuso, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Claudia Melis, Benedetta Fois, Andrea Angeli, Clemente Capasso, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1526-1533 (2019)

A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitor

Externí odkaz: https://doaj.org/article/3c9f17df024d4132a83d710a56a3090b

Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

Autor: Claudiu T. Supuran, Pierluigi Caboni, Andrea Angeli, Elias Maccioni, Filippo Cottiglia, Mariella Nieddu, Claudia Sissi, Costantino Floris, Antonella Rosa, Benedetta Fois, Serenella Deplano, Rita Meleddu, Simona Distinto

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 539-548 (2020)

In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc63f09e368df52f6161efb34fbd171
http://europepmc.org/articles/PMC7006766

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

Autor: Rossella Angius, Francesco Ortuso, Stefano Alcaro, Clemente Capasso, Claudiu T. Supuran, Simona Distinto, Claudia Melis, Andrea Angeli, Lisa Sequeira, Benedetta Fois, Filippo Cottiglia, Serenella Deplano, Rita Meleddu, Elias Maccioni

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of enzyme inhibition and medicinal chemistry
34 (2019): 1526–1533. doi:10.1080/14756366.2019.1654470
info:cnr-pdr/source/autori:Distinto, Simona; Meleddu, Rita; Ortuso, Francesco; Cottiglia, Filippo; Deplano, Serenella; Sequeira, Lisa; Melis, Claudia; Fois, Benedetta; Angeli, Andrea; Capasso, Clemente; Angius, Rossella; Alcaro, Stefano; Supuran, Claudiu T.; Maccioni, Elias/titolo:Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases/doi:10.1080%2F14756366.2019.1654470/rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2019/pagina_da:1526/pagina_a:1533/intervallo_pagine:1526–1533/volume:34
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1526-1533 (2019)

A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e63655de220d982e7827142bdb882d6
https://doi.org/10.1080/14756366.2019.1654470

Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides

Autor: Matilde Yáñez, Domenico Taverna, Claudiu T. Supuran, Marco Gaspari, Andrea Angeli, Claudia Melis, Filippo Cottiglia, Clemente Capasso, Simona Distinto, Francesco Ortuso, Sonia Del Prete, Benedetta Fois, Elias Maccioni, Stefano Alcaro, Giulia Bianco, Rossella Angius, Serenella Deplano, Rita Meleddu

Publikováno v: ACS medicinal chemistry letters (2018). doi:10.1021/acsmedchemlett.8b00352
info:cnr-pdr/source/autori:Meleddu R.; Distinto S.; Cottiglia F.; Angius R.; Gaspari M.; Taverna D.; Melis C.; Angeli A.; Bianco G.; Deplano S.; Fois B.; Del Prete S.; Capasso C.; Alcaro S.; Ortuso F.; Yanez M.; Supuran C.T.; Maccioni E./titolo:Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides/doi:10.1021%2Facsmedchemlett.8b00352/rivista:ACS medicinal chemistry letters/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume

[Image: see text] A novel series of of 4-[(3-phenyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides (EMAC10111a–g) was synthesized and assayed toward both human carbonic anhydrase isozymes I, II, IX, and XII and cyclooxygenase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7956bcc779416e7348e4b82cae92aba0
https://doi.org/10.1021/acsmedchemlett.8b00352