Výsledky vyhledávání - "Serena Vegna"

Akademický článek

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

Autor: Christel F. A. Ramirez, Daniel Taranto, Masami Ando-Kuri, Marnix H. P. de Groot, Efi Tsouri, Zhijie Huang, Daniel de Groot, Roelof J. C. Kluin, Daan J. Kloosterman, Joanne Verheij, Jing Xu, Serena Vegna, Leila Akkari

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)

Abstract Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course of tumorigenesis. Yet several aspects underlying their dynamic alter

Externí odkaz: https://doaj.org/article/8fdb0db866fb4b6fba788951b3b0d68b

Zobrazit plný text záznamu

Akademický článek

Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

Autor: Anthony Lozano, Francois-Régis Souche, Carine Chavey, Valérie Dardalhon, Christel Ramirez, Serena Vegna, Guillaume Desandre, Anaïs Riviere, Amal Zine El Aabidine, Philippe Fort, Leila Akkari, Urszula Hibner, Damien Grégoire

Publikováno v: eLife, Vol 12 (2023)

Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell fates being driven

Externí odkaz: https://doaj.org/article/a6847e4afd534521b7463f84208c628a

Zobrazit plný text záznamu

Akademický článek

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.

Publikováno v: PLoS Pathogens, Vol 16, Iss 11, p e1008593 (2020)

Despite the existence of a preventive vaccine, chronic infection with Hepatitis B virus (HBV) affects more than 250 million people and represents a major global cause of hepatocellular carcinoma (HCC) worldwide. Current clinical treatments, in most o

Externí odkaz: https://doaj.org/article/151d937cb76042be9e95646ac4073046

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers

Autor: Karoline Kielbassa, Serena Vegna, Christel Ramirez, Leila Akkari

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Tumor-associated macrophages (TAMs) are a major component of the tumor immune microenvironment (TIME) and are associated with a poor prognostic factor in several cancers. TAMs promote tumor growth by facilitating immunosuppression, angiogenesis, and

Externí odkaz: https://doaj.org/article/b4e7477ff3b7496b8b0c2e3a21ae32a5

Zobrazit plný text záznamu

Akademický článek

Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.

Autor: Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Jacques Piette, Nicolas Floc'h, Patrice Lassus, Guann-Yi Yu, Arielle R Rosenberg, Michael Karin, David Durantel, Urszula Hibner

Publikováno v: PLoS Pathogens, Vol 9, Iss 3, p e1003234 (2013)

Exposure to hepatitis C virus (HCV) typically results in chronic infection that leads to progressive liver disease ranging from mild inflammation to severe fibrosis and cirrhosis as well as primary liver cancer. HCV triggers innate immune signaling w

Externí odkaz: https://doaj.org/article/aba6c2c467324ee39aea21eea458e347

Zobrazit plný text záznamu

Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms

Publikováno v: Journal of Hepatology
Journal of Hepatology, In press, ⟨10.1016/j.jhep.2023.01.005⟩
Journal of Hepatology, 78(5), 958-970. Elsevier

Background & Aims: Chronic coinfection with HBV and HDV leads to the most aggressive form of chronic viral hepatitis. Herein, we aimed to elucidate the molecular mechanisms underlying the widely reported observation that HDV interferes with HBV in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3b3eff3a87ef013cb5c6dbae104bda

Zobrazit plný text záznamu

EGFR activation limits the response of liver cancer to lenvatinib

Publikováno v: Nature. 595:730-734

Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options1. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinases that is used for the treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1929052673bdfe45b7dd81e438ff9f3d
https://doi.org/10.1038/s41586-021-03741-7

Zobrazit plný text záznamu

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

Autor: Rebeca, Uceda-Castro, Andreia S, Margarido, Lesley, Cornet, Serena, Vegna, Kerstin, Hahn, Ji-Ying, Song, Diana A, Putavet, Mariska, van Geldorp, Ceren H, Çitirikkaya, Peter L J, de Keizer, Leon C, Ter Beek, Gerben R, Borst, Leila, Akkari, Olaf, van Tellingen, Marike L D, Broekman, Claire, Vennin, Jacco, van Rheenen

Publikováno v: Cell Reports Medicine. 3:100821

An increasing number of breast cancer patients develop brain metastases (BM). Standard-of-care treatments are largely inefficient, and breast cancer brain metastasis (BCBM) patients are considered untreatable. Immunotherapies are not successfully emp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8217ebde6a1b86fc7ee8118f1a0abe16
https://doi.org/10.1016/j.xcrm.2022.100821

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání