The Phytophthora parasitica effector AVH195 interacts with ATG8, attenuates host autophagy, and promotes biotrophic infection

Autor: Serena Testi, Marie-Line Kuhn, Valérie Allasia, Pascaline Auroy, Fantao Kong, Gilles Peltier, Sophie Pagnotta, Julie Cazareth, Harald Keller, Franck Panabières

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)

Abstract Background Plant pathogens secrete effector proteins into host cells to suppress immune responses and manipulate fundamental cellular processes. One of these processes is autophagy, an essential recycling mechanism in eukaryotic cells that c

Externí odkaz: https://doaj.org/article/2522bf66d54b4712a22c594730eda910

UCTD and SLE patients show increased levels of oxidative and DNA damage together with an altered kinetics of DSB repair

Autor: Alice Parma, Serena Testi, Aurora Falaschi, Marta Mosca, Chiara Tani, Anna Chiaramonte, Consuelo Micheli, Domenica Di Bello, Roberto Scarpato

Publikováno v: Mutagenesis. 36(6)

Immunological tolerance is a critical feature of the immune system; its loss might lead to an abnormal response of lymphocytes causing autoimmune diseases. One of the most important groups belonging to autoimmune disorders is the connective tissue di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fdd7b2bda5328e8625fd69bfd130d5
https://pubmed.ncbi.nlm.nih.gov/34559237

Vincristine-induced bystander effect in human lymphocytes

Autor: Serena Testi, Sara Lombardi, Maria Sole Facioni, Caterina Giovannini, Simona Piaggi, Alessia Azzarà, Roberto Scarpato

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 789:39-47

Bystander effect is a known radiobiological effect, widely described using ionizing radiations and which, more recently, has also been related to chemical mutagens. In this study, we aimed to assess whether or not a bystander response can be induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b7e56f8e861fd4cdc781094746e437
https://doi.org/10.1016/j.mrfmmm.2016.03.001

Kinetics of nuclear phosphorylation ( -H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C

Autor: Sara Castagna, Caterina Giovannini, Erika Filomeni, Serena Testi, Alessia Azzarà, Sara Lombardi, Roberto Scarpato, Francesco Ghetti, Antonio Tomei, Chiara Pirillo, Rosamaria Aliotta

Publikováno v: Mutagenesis 28 (2013): 465–473. doi:10.1093/mutage/get024
info:cnr-pdr/source/autori:Scarpato R, Castagna S, Aliotta R, Azzara A, Ghetti F, Filomeni E, Giovannini C, Pirillo C, Testi S, Lombardi S, Tomei A/titolo:Kinetics of nuclear phosphorylation (-H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C/doi:10.1093%2Fmutage%2Fget024/rivista:Mutagenesis/anno:2013/pagina_da:465/pagina_a:473/intervallo_pagine:465–473/volume:28

After double-strand break induction, formation of ?-H2AX foci due to phosphorylation at Ser-139 of histone H2AX represents an early event of the DNA damage response (DDR). ?-H2AX foci are then rapidly dephosphorylated as signal for the subsequent rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be38555202194c662f8f2798eab5b820
https://doi.org/10.1093/mutage/get024