Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Serena Nik Zainal"'
Autor:
Sruthi Cheloor Kovilakam, Muxin Gu, William G. Dunn, Ludovica Marando, Clea Barcena, Serena Nik Zainal, Irina Mohorianu, Siddhartha P. Kar, Margarete A. Fabre, Pedro M. Quiros, George S. Vassiliou
Publikováno v:
HemaSphere, Vol 7, p e363625f (2023)
Externí odkaz:
https://doaj.org/article/8a678ccaaaf744899007bb7fdd197b43
Autor:
Marine Inglebert, Martina Dettwiler, Kerstin Hahn, Anna Letko, Cord Drogemuller, John Doench, Adam Brown, Yasin Memari, Helen R. Davies, Andrea Degasperi, Serena Nik-Zainal, Sven Rottenberg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression patterns, prognostic
Externí odkaz:
https://doaj.org/article/1b8033cd3024446a898fc0b4f392563e
Autor:
Christine L. Jones, Andrea Degasperi, Vieri Grandi, Tauanne D. Amarante, Genomics England Research Consortium, Tracey J. Mitchell, Serena Nik-Zainal, Sean J. Whittaker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract T-cell non-Hodgkin’s lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin’s lymphoma to identify mu
Externí odkaz:
https://doaj.org/article/14f26d51c7e44279991de8475f3bb7bb
Autor:
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona, Serena Nik-Zainal, Åke Borg, Johan Staaf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
BRCA-deficient breast cancer is characterised by homologous recombination deficiency. Here, the authors show that hypermethylated BRCA1 phenotypically copies mutated BRCA1 in triple negative breast cancers.
Externí odkaz:
https://doaj.org/article/364ce59486504bf6a831a413fa23b595
Autor:
Neha Chopra, Holly Tovey, Alex Pearson, Ros Cutts, Christy Toms, Paula Proszek, Michael Hubank, Mitch Dowsett, Andrew Dodson, Frances Daley, Divya Kriplani, Heidi Gevensleben, Helen Ruth Davies, Andrea Degasperi, Rebecca Roylance, Stephen Chan, Andrew Tutt, Anthony Skene, Abigail Evans, Judith M. Bliss, Serena Nik-Zainal, Nicholas C. Turner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Defects in homologous recombination (HR) are found in some triple negative breast cancers, suggesting they may be sensitive to PARP inhibitors. In this phase II clinical trial of the PARP inhibitor rucaparib, changes in Ki67 levels did not correlate
Externí odkaz:
https://doaj.org/article/16335d8252804f3a9e5594503bbf84fa
Autor:
Ilias Georgakopoulos-Soares, Gene Koh, Sophie E. Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Indels that are commonly found in cancer genomes are characterized by non-random sequence composition and localisation. Here, the authors described a method to investigate transcriptional strand asymmetries and sequence-context specific mechanisms th
Externí odkaz:
https://doaj.org/article/330a18a3bad7426cba3f743bc68365db
Autor:
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in human pluripotent stem cells (PSC) and whether any form during culture prior to use in a human clinical context are a concern. Here, the authors use hPSCs derived to cGMP standards and show they have low mutation rates after culture, not
Externí odkaz:
https://doaj.org/article/6f55e007701f4013b3a7b971436b8888
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures are underway.
Externí odkaz:
https://doaj.org/article/6c395d5c25eb4d99845823b9d0d1d495
Autor:
Megan L. Kruse, Mona Patel, Jeffrey McManus, Yoon-Mi Chung, Xiuxiu Li, Wei Wei, Peter S. Bazeley, Fumihiko Nakamura, Aimalie Hardaway, Erinn Downs, Sarat Chandarlapaty, Mathew Thomas, Halle C.F. Moore, George T. Budd, W.H. Wilson Tang, Stanley L. Hazen, Aaron Bernstein, Serena Nik-Zainal, Jame Abraham, Nima Sharifi
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
BACKGROUND Genetics of estrogen synthesis and breast cancer risk has been elusive. The 1245A→C missense-encoding polymorphism in HSD3B1, which is common in White populations, is functionally adrenal permissive and increases synthesis of the aromata
Externí odkaz:
https://doaj.org/article/5d4adf6bdf6f4dbfb12d6380de88f28d
Autor:
Helen R. Davies, Kirsty Hodgson, Edward Schwalbe, Jonathan Coxhead, Naomi Sinclair, Xueqing Zou, Simon Cockell, Akhtar Husain, Serena Nik-Zainal, Neil Rajan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
CYLD cutaneous syndrome (also known as Brooke-Spiegler syndrome) is characterised by germline mutations in the tumor suppressor CYLD. Here, the authors highlight recurrent mutations in DNMT3A and BCOR, indicating a role for epigenetic dysregulation i
Externí odkaz:
https://doaj.org/article/455161ea0e7d48609e0545f51dafe8d6