Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Serena Marchiò"'
Autor:
Annamaria Massa, Caterina Peraldo-Neia, Francesca Vita, Chiara Varamo, Marco Basiricò, Chiara Raggi, Paola Bernabei, Jessica Erriquez, Ivana Sarotto, Francesco Leone, Serena Marchiò, Giuliana Cavalloni, Massimo Aglietta
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The treatment of unresectable cholangiocarcinoma (CCA) is limited by the development of resistance to conventional first-line chemotherapy based on gemcitabine (GEM). In addition, a prior treatment with GEM frequently induces cross-resistance to othe
Externí odkaz:
https://doaj.org/article/4ca669a711f344dbb310548605d05bd9
Autor:
Elisabetta Marini, Marco Marino, Giulia Gionfriddo, Federica Maione, Marta Pandini, Daniele Oddo, Marta Giorgis, Barbara Rolando, Federica Blua, Simone Gastaldi, Serena Marchiò, Sandra Kovachka, Francesca Spyrakis, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Publikováno v:
Molecules, Vol 27, Iss 23, p 8513 (2022)
BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAFV600E mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resis
Externí odkaz:
https://doaj.org/article/321ff11884e9491784732a391526bf64
Autor:
Andre A Teixeira, Serena Marchiò, Emmanuel Dias‐Neto, Diana N Nunes, Israel T da Silva, Bryce Chackerian, Marc Barry, Richard C Lauer, Ricardo J Giordano, Richard L Sidman, Cosette M Wheeler, Webster K Cavenee, Renata Pasqualini, Wadih Arap
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1327-1330 (2017)
Graphical Abstract The hypothesis is discussed that prostate cancer marker lncRNA PCA3 was introduced into the human genome by an oncogenic virus, and that viral infection‐related mechanisms might underlie its overexpression and prostate cancer ini
Externí odkaz:
https://doaj.org/article/8d221eac6f144f378b13373e38c5f65b
Autor:
Daniela I. Staquicini, Roberto Rangel, Liliana Guzman-Rojas, Fernanda I. Staquicini, Andrey S. Dobroff, Christy A. Tarleton, Michelle A. Ozbun, Mikhail G. Kolonin, Juri G. Gelovani, Serena Marchiò, Richard L. Sidman, Katherine A. Hajjar, Wadih Arap, Renata Pasqualini
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Cytoskeletal-associated proteins play an active role in coordinating the adhesion and migration machinery in cancer progression. To identify functional protein networks and potential inhibitors, we screened an internalizing phage (iPhage) di
Externí odkaz:
https://doaj.org/article/5856840a50164afb9f65b36ea3d9f06a
Autor:
Valentina Foglizzo, Serena Marchiò
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 161 (2021)
Evolution of nanomedicine is the re-design of synthetic and biological carriers to implement novel theranostic platforms. In recent years, bacteriophage research favors this process, which has opened up new roads in drug and gene delivery studies. By
Externí odkaz:
https://doaj.org/article/266e679cab4a4acab4ee70cc65ae03b8
Publikováno v:
Molecules, Vol 25, Iss 4, p 843 (2020)
Phage display is a nanotechnology with limitless potential, first developed in 1985 and still awaiting to reach its peak. Awarded in 2018 with the Nobel Prize for Chemistry, the method allows the isolation of high-affinity ligands for diverse substra
Externí odkaz:
https://doaj.org/article/38e14a601c724e098925ce8e67c59b06
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 6, Pp 592-594 (2016)
Abstract Neurovascular disorders are difficult to treat due to the blood–brain barrier (BBB), which prevents delivery of most drugs from the blood into the brain. Gene therapy can potentially overcome this barrier, but classical vectors are neither
Externí odkaz:
https://doaj.org/article/ad9b36cec15a47879f662fbb001e7f4a
Autor:
Francesco Leone, Massimo Aglietta, Serena Marchiò, Marco Soster, Giorgia Migliardi, Loretta Gammaitoni, Ivana Sarotto, Caterina Peraldo-Neia, Giuliana Cavalloni
PDF file, 19KB, TUNEL staining of BTC cell lines untreated (NT) and treated (SAR) with Saracatinib at the concentration of 5 �M for 24 hours. A statistical significant increase of apoptosis was seen in all the cell lines ( p-value < 0.05) except in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc95c9f158d0278ddcd99e504851e4f0
https://doi.org/10.1158/1535-7163.22497591
https://doi.org/10.1158/1535-7163.22497591
Autor:
Francesco Leone, Massimo Aglietta, Serena Marchiò, Marco Soster, Giorgia Migliardi, Loretta Gammaitoni, Ivana Sarotto, Caterina Peraldo-Neia, Giuliana Cavalloni
PDF file, 21KB, Ki-67 staining of tumor tissue sections derived from vehicle (A) and Saracatinib treated group (B). A statistical significant decrease of proliferation was seen in treated mice (C) (p-value = 0.0003). NT: vehicle-treated mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546f2204ce5b60a19b54c674bdb8b027
https://doi.org/10.1158/1535-7163.22497588.v1
https://doi.org/10.1158/1535-7163.22497588.v1
Autor:
Francesco Leone, Massimo Aglietta, Serena Marchiò, Marco Soster, Giorgia Migliardi, Loretta Gammaitoni, Ivana Sarotto, Caterina Peraldo-Neia, Giuliana Cavalloni
PDF file, 28KB, Statistical analysis of reduction of cell proliferation by saracatinib in BTC cell lines. A statistical significant inhibition was revealed up to 1.25 �M in all the cell lines, except for TGBC1, in which no significance was found. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddbee52f528d556a8f48c7b814a0b5b
https://doi.org/10.1158/1535-7163.22497597.v1
https://doi.org/10.1158/1535-7163.22497597.v1