Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Serena L Cole"'
1
Akademický článek
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.
Autor: Jerry R Colca, William G McDonald, Gregory S Cavey, Serena L Cole, Danielle D Holewa, Angela S Brightwell-Conrad, Cindy L Wolfe, Jean S Wheeler, Kristin R Coulter, Peter M Kilkuskie, Elena Gracheva, Yulia Korshunova, Michelle Trusgnich, Robert Karr, Sandra E Wiley, Ajit S Divakaruni, Anne N Murphy, Patrick A Vigueira, Brian N Finck, Rolf F Kletzien
Publikováno v: PLoS ONE, Vol 8, Iss 5, p e61551 (2013)
Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects that are mediated via activation of the transcription factor PPARγ
Externí odkaz: https://doaj.org/article/810bfe5fc88043a1a3d87fdcdaabf016
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2
Akademický článek
Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
Autor: Patrick A. Vigueira, Kyle S. McCommis, George G. Schweitzer, Maria S. Remedi, Kari T. Chambers, Xiaorong Fu, William G. McDonald, Serena L. Cole, Jerry R. Colca, Rolf F. Kletzien, Shawn C. Burgess, Brian N. Finck
Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 2042-2053 (2014)
Carrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that facili
Externí odkaz: https://doaj.org/article/0d9bb6c80ceb445b921d7c646f9c7d02
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3
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism
Autor: Lalita Oonthonpan, Rolf F. Kletzien, Eric B. Taylor, Jerry R. Colca, Serena L. Cole, George G. Schweitzer, William G. McDonald, Patrick A. Vigueira, Wesley T. Hodges, Brian N. Finck, Kyle S. McCommis
Publikováno v: Experimental Physiology. 102:985-999
Rosiglitazone and pioglitazone are thiazolidinedione (TZD) compounds that have been used clinically as insulin-sensitizing drugs and are generally believed to mediate their effects via activation of the peroxisome proliferator-activated receptor γ (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4f7b85b1cc3600423efdcc0a0c3e843
https://doi.org/10.1113/ep086380
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4
Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
Autor: Kyle S. McCommis, Rolf F. Kletzien, Brian N. Finck, Xiaorong Fu, Patrick A. Vigueira, Shawn C. Burgess, Serena L. Cole, Jerry R. Colca, Kari T. Chambers, William G. McDonald, George G. Schweitzer, Maria S. Remedi
Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 2042-2053 (2014)
SummaryCarrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6e5ee8cbc898411b403e220f21c7de
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6
[Untitled]
Autor: Margaret M. McShane, Stephen R. Davio, Serena L. Cole, Renee M. Zaya, Thomas J. Kakuk
Publikováno v: Pharmaceutical Research. :80-83
Ditekiren is a pseudo-octapeptide being developed as an inhibitor of human renin. Preclinical drug safety studies with this drug involved continuous iv infusions through indwelling catheters in the right internal jugular vein of the cynomolgus monkey
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0540b344c7051af92af001fd2db0b26b
https://doi.org/10.1023/a:1015886424586
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8
A human respiratory syncytial virus (RSV) primate model of enhanced pulmonary pathology induced with a formalin-inactivated RSV vaccine but not a recombinant FG subunit vaccine
Autor: Roger J. Brideau, Wells Pa, Zhang Jy, Serena L. Cole, Roberts Ed, Thomas J. Kakuk, Kenneth F. Soike, Renee M. Zaya, M.W. Wathen
Publikováno v: The Journal of infectious diseases. 167(3)
Human respiratory syncytial virus (RSV) is the leading cause of severe bronchiolitis and pneumonia in infants. RSV vaccine development has been stifled for the past 23 years because infants vaccinated with formalin-inactivated (FI) RSV have experienc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e9419c7a0ae5025c2c8f34e4f2add1
https://pubmed.ncbi.nlm.nih.gov/8440926
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9
Vaccination of cotton rats with a chimeric FG glycoprotein of human respiratory syncytial virus induces minimal pulmonary pathology on challenge
Autor: Thomas J. Kakuk, Michael W. Wathen, Renee M. Zaya, Edward C. Hausknecht, Serena L. Cole, Roger J. Brideau
Publikováno v: The Journal of infectious diseases. 163(3)
The cotton rat model of human respiratory syncytial virus (RSV) infection was used to study the safety and efficacy of a chimeric FG glycoprotein that was expressed in insect cells using a baculovirus vector. Histologic and virologic examination of v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ccc02640d175f9e132caf86135abd6
https://pubmed.ncbi.nlm.nih.gov/1995720
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