Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Serena K Perna"'
Autor:
Adham S Bear, Laura C Kennedy, Joseph K Young, Serena K Perna, Joao Paulo Mattos Almeida, Adam Y Lin, Phillip C Eckels, Rebekah A Drezek, Aaron E Foster
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69073 (2013)
Ablative treatments such as photothermal therapy (PTT) are attractive anticancer strategies because they debulk accessible tumor sites while simultaneously priming antitumor immune responses. However, the immune response following thermal ablation is
Externí odkaz:
https://doaj.org/article/5669772c71314b089987371bba19e559
Autor:
Barbara Savoldo, Gianpietro Dotti, Cliona M. Rooney, Malcolm K. Brenner, Helen E. Heslop, Aruna Mahendravada, Lan Zhang, Sayyeda T. Hasan, Daria Pagliara, Biagio De Angelis, Serena K. Perna
Purpose: Systemic administration of recombinant interleukin (IL)-2 is used to support the expansion and persistence of adoptively transferred antigen-specific CTLs in patients with cancer. However, IL-2 also expands regulatory T cells (Treg) that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660201ce53403c7749bd1d31ef721212
https://doi.org/10.1158/1078-0432.c.6520659.v1
https://doi.org/10.1158/1078-0432.c.6520659.v1
Autor:
Barbara Savoldo, Gianpietro Dotti, Cliona M. Rooney, Malcolm K. Brenner, Helen E. Heslop, Aruna Mahendravada, Lan Zhang, Sayyeda T. Hasan, Daria Pagliara, Biagio De Angelis, Serena K. Perna
PDF file - 55K, Suppl. Table 1. Recovery of Tregs from healthy donors and from HL patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647b227c1671f8553f2e2201352e9037
https://doi.org/10.1158/1078-0432.22446126
https://doi.org/10.1158/1078-0432.22446126
Autor:
Gianpietro Dotti, Barbara Savoldo, Malcolm K. Brenner, Hao Liu, Aruna Mahendravada, Daria Pagliara, Serena K. Perna
PDF file 77K, IL7Ra.CAR-GD2 CTLs were stimulated with EBV-LCLs (ratio 1:1 or 1:2) and then 2 hours later we detected the production of IL-2 by intracellular staining and FACS analysis. CTLs without antigen stimulation and PMA/Ionomycin and Staphyloco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e390f755b83094ab6210d47804e2d4
https://doi.org/10.1158/1078-0432.22447869.v1
https://doi.org/10.1158/1078-0432.22447869.v1
Autor:
Barbara Savoldo, Gianpietro Dotti, Cliona M. Rooney, Malcolm K. Brenner, Helen E. Heslop, Aruna Mahendravada, Lan Zhang, Sayyeda T. Hasan, Daria Pagliara, Biagio De Angelis, Serena K. Perna
PDF file - 67K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8672983a565979ba96ea25b62f8005
https://doi.org/10.1158/1078-0432.22446132
https://doi.org/10.1158/1078-0432.22446132
Autor:
Gianpietro Dotti, Barbara Savoldo, Malcolm K. Brenner, Hao Liu, Aruna Mahendravada, Daria Pagliara, Serena K. Perna
Purpose: The antitumor activity of chimeric antigen receptor (CAR)–redirected CTLs should be enhanced if it were possible to increase their proliferation and function after adoptive transfer without concomitantly increasing the proliferation and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f115d6a289c255101f7ebc2e7ba2a5
https://doi.org/10.1158/1078-0432.c.6521238
https://doi.org/10.1158/1078-0432.c.6521238
Autor:
Barbara Savoldo, Gianpietro Dotti, Cliona M. Rooney, Malcolm K. Brenner, Helen E. Heslop, Aruna Mahendravada, Lan Zhang, Sayyeda T. Hasan, Daria Pagliara, Biagio De Angelis, Serena K. Perna
PDF file - 117K, Suppl. Fig. 1. Immunophenotypic characterization of CD4+CD25bright cells and other T-cell subsets isolated from peripheral blood of healthy donors. Suppl. Fig. 2. Titration of the inhibitory function of Tregs and selection of Tregs b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c1b1fda84dc7c31bec9da4d6fbdce2
https://doi.org/10.1158/1078-0432.22446129.v1
https://doi.org/10.1158/1078-0432.22446129.v1
Autor:
Rikhia Chakraborty, Aruna Mahendravada, Serena K. Perna, Cliona M. Rooney, Helen E. Heslop, Juan F. Vera, Barbara Savoldo, Gianpietro Dotti
Publikováno v:
Haematologica, Vol 98, Iss 4 (2013)
The low frequency of naturally occurring regulatory T cells (nTregs) in peripheral blood and the suboptimal protocols available for their ex vivo expansion limit the development of clinical trials based on the adoptive transfer of these cells. We hav
Externí odkaz:
https://doaj.org/article/f31c40f1ad4e4bd488186e985f04b779
Autor:
Wolfram Brugger, Frederick Arce Vargas, Virginie Cerec, Martin Pule, Claire Roddie, Paul Shaughnessy, Kevin J. Duffy, Gerardo Santiago Toledo, Serena K. Perna, Michael Merges, Abigail Culshaw
Publikováno v:
Blood. 138:477-477
INTRODUCTION We have previously described AUTO1, a CD19 CAR with a fast off-rate binding domain, designed to reduce CAR T-cell immune toxicity and improve engraftment. Clinical testing in two academic studies in relapsed/refractory (r/r) paediatric [
Autor:
Hao Liu, Aruna Mahendravada, Malcolm K. Brenner, Serena K. Perna, Barbara Savoldo, Gianpietro Dotti, Daria Pagliara
Publikováno v:
Clinical Cancer Research. 20:131-139
Purpose: The antitumor activity of chimeric antigen receptor (CAR)–redirected CTLs should be enhanced if it were possible to increase their proliferation and function after adoptive transfer without concomitantly increasing the proliferation and fu