Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Serena J Chee"'
Autor:
Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Gareth Thomas, Peter S Friedmann, Pandurangan Vijayanand, Tilman Sanchez-Elsner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and
Externí odkaz:
https://doaj.org/article/78a908b9b0784fee9b20195130c12164
Autor:
Mark G Jones, Orestis G Andriotis, James JW Roberts, Kerry Lunn, Victoria J Tear, Lucy Cao, Kjetil Ask, David E Smart, Alessandra Bonfanti, Peter Johnson, Aiman Alzetani, Franco Conforti, Regan Doherty, Chester Y Lai, Benjamin Johnson, Konstantinos N Bourdakos, Sophie V Fletcher, Ben G Marshall, Sanjay Jogai, Christopher J Brereton, Serena J Chee, Christian H Ottensmeier, Patricia Sime, Jack Gauldie, Martin Kolb, Sumeet Mahajan, Aurelie Fabre, Atul Bhaskar, Wolfgang Jarolimek, Luca Richeldi, Katherine MA O'Reilly, Phillip D Monk, Philipp J Thurner, Donna E Davies
Publikováno v:
eLife, Vol 7 (2018)
Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in hum
Externí odkaz:
https://doaj.org/article/2541e80c33c2458ba21e589aed967251
Autor:
Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J. J. Rose-Zerilli, Gareth J. Thomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohi
Externí odkaz:
https://doaj.org/article/90c9737e349b4a0f860180335c1700ab
Autor:
Simon Eschweiler, Alice Wang, Ciro Ramírez-Suástegui, Adrian von Witzleben, Yingcong Li, Serena J. Chee, Hayley Simon, Monalisa Mondal, Matthew Ellis, Gareth J. Thomas, Vivek Chandra, Christian H. Ottensmeier, Pandurangan Vijayanand
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112040- (2023)
Summary: Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action wit
Externí odkaz:
https://doaj.org/article/327579dd01244769ba874a0df16d447c
Autor:
William J Pandori, Lindsey E Padgett, Ahmad Alimadadi, Norma A Gutierrez, Daniel J Araujo, Christine J Huh, Claire E Olingy, Huy Q Dinh, Runpei Wu, Pandurangan Vijayanand, Serena J Chee, Christian H Ottensmeier, Catherine C Hedrick
Publikováno v:
Journal of Leukocyte Biology. 112:1053-1063
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in severe immune dysfunction, hospitalization, and death. Many patients also develop long-COVID-19, experiencing symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa504c5cb06e9a7e2ed06fe2281861d6
https://doi.org/10.1002/jlb.4cova0122-076r
https://doi.org/10.1002/jlb.4cova0122-076r
Autor:
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendéus, Ramsey I. Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Journal of Experimental & Clinical Cancer Research. 41
Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophages (TAMs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c563f96abe6681604c643ffcf11009
https://doi.org/10.1186/s13046-022-02294-5
https://doi.org/10.1186/s13046-022-02294-5
Autor:
Ferhat Ay, Serena J Chee, Sourya Bhattacharyya, Tilman Sanchez-Elsner, Edwin Woo, Katy J. McCann, Christopher J. Hanley, Christian H. Ottensmeier, Anusha-Preethi Ganesan, Emma King, Aiman Alzetani, Simon Eschweiler, Ravindra Gujar, Bharat Panwar, Oliver Wood, Peter S Friedmann, Gareth J. Thomas, James Clarke, Pandurangan Vijayanand, Ariel Madrigal, Amiera S Awad, Grégory Seumois, Divya Singh
Publikováno v:
The Journal of Experimental Medicine
Clarke et al. interrogate human TRM cells from cancer and nonmalignant tissue. These analyses highlight that PD-1 expression in tumor-infiltrating TRM cells was positively correlated with features suggestive of active proliferation and superior funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deed04325b5dee5a3291fd7f5265d4b6
https://doi.org/10.1084/jem.20190249
https://doi.org/10.1084/jem.20190249
Autor:
Christian H. Ottensmeier, Jo Tod, Julian Taylor, Oliver Wood, Lulu Tanno, Maria Antonette Lopez, Serena J Chee, Judith Cave, Maria Machado, Margaret Ashton-Key, Peter S. Friedmann, Jonathan Dunbar, Gareth J. Thomas, Salma Naheed, Neil W. Pearce, Bryan Green
Publikováno v:
Neuroendocrinology. 112(4)
Introduction: Neuroendocrine tumours (NETs) are rare tumours with an increasing incidence. While low- and intermediate-grade pancreatic NET (PanNET) and small intestinal NET (siNET) are slow growing, they have a relatively high rate of metastasizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6a8642b14edbd1d99d4d7c8ba1bff5
https://pubmed.ncbi.nlm.nih.gov/34157710
https://pubmed.ncbi.nlm.nih.gov/34157710
Autor:
Vicente Fajardo, Christian H. Ottensmeier, Anthony Kusnadi, Grégory Seumois, Ciro Ramírez-Suástegui, Serena J Chee, Hayley Simon, Ferhat Ay, Pandurangan Vijayanand, Emanuela Pelosi, Benjamin J Meckiff
Publikováno v:
Science Immunology
The molecular properties of CD8+ T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8+ T cells, obtained using a modified Antigen-Reactive T cell Enrichment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c7cd7244212d3fa9e15016c0cb1caa
Autor:
Anthony Kusnadi, Ciro Ramírez-Suástegui, Alessandro Sette, Serena J Chee, Vicente Fajardo, Benjamin J Meckiff, Pandurangan Vijayanand, Daniela Weiskopf, Ferhat Ay, Hayley Simon, Grégory Seumois, Emanuela Pelosi, Simon Eschweiler, Alba Grifoni, Christian H. Ottensmeier
Publikováno v:
Cell
SSRN
SSRN
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca7611b924f72dd95821a1f6f25b5dd