Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Serena Guidotti"'
Autor:
Serena Guidotti, Manuela Minguzzi, Daniela Platano, Luca Cattini, Giovanni Trisolino, Erminia Mariani, Rosa Maria Borzì
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143865 (2015)
Recent evidence suggests that GSK3 activity is chondroprotective in osteoarthritis (OA), but at the same time, its inactivation has been proposed as an anti-inflammatory therapeutic option. Here we evaluated the extent of GSK3β inactivation in vivo
Externí odkaz:
https://doaj.org/article/2dfe1b1e22224359bc77ae2f43df284d
Autor:
Annalisa Facchini, Silvia Cetrullo, Stefania D'Adamo, Serena Guidotti, Manuela Minguzzi, Andrea Facchini, Rosa Maria Borzì, Flavio Flamigni
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109724 (2014)
Hydroxytyrosol (HT), a phenolic compound mainly derived from olives, has been proposed as a nutraceutical useful in prevention or treatment of degenerative diseases. In the present study we have evaluated the ability of HT to counteract the appearanc
Externí odkaz:
https://doaj.org/article/d076312fb61c42ffaebdab5168f9ad0b
Autor:
Simona Neri, Serena Guidotti, Stefania D'Adamo, Rosa Maria Borzì, Luca Cattini, Spartaco Santi, Susi Pelotti, Erminia Mariani, Daniela Platano, Manuela Minguzzi, Carla Bini
Publikováno v:
Free Radical Biology and Medicine. 166:212-225
During osteoarthritis development, chondrocytes are subjected to a functional derangement. This increases their susceptibility to stressful conditions such as oxidative stress, a characteristic of the aging tissue, which can further provoke extrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e37853cdee188f1cfddd494a2bf4b63
https://doi.org/10.1016/j.freeradbiomed.2021.02.020
https://doi.org/10.1016/j.freeradbiomed.2021.02.020
Autor:
Silvia Cetrullo, Serena Guidotti, Ylenia Silvestri, Flavio Flamigni, Stefania D'Adamo, Manuela Minguzzi, Rosa Maria Borzì, Spartaco Santi, Giuseppe Filardo, Luca Cattini
Oxidative stress (OS) contributes to Osteoarthritis (OA) pathogenesis and its effects are worsened by the impairment of homeostatic mechanisms such as autophagy in OA chondrocytes. Rescue of an efficient autophagic flux could therefore reduce the bul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5aa46d5fd259bcbc1f6d03c26721c3
http://hdl.handle.net/11585/762591
http://hdl.handle.net/11585/762591
Publikováno v:
Journal of Orthopaedic Research. 35:1029-1037
Different sources of mesenchymal stromal cells can be considered for regenerative medicine applications. Here we analyzed human adipose-derived stromal cells from infrapatellar fat pad (IFPSC) of osteoarthritis patients, representing a very interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebb21a4aec4ec3714a2c3f56bf002056
https://doi.org/10.1002/jor.23349
https://doi.org/10.1002/jor.23349
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1181-1191
Background Hydroxytyrosol (HT), a major phenolic antioxidant found in olive oil, can afford protection from oxidative stress in several types of non-tumoral cells, including chondrocytes. Autophagy was recently identified as a protective process duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1df2408cdfb4d3f4207515381d7368
https://doi.org/10.1016/j.bbagen.2016.03.002
https://doi.org/10.1016/j.bbagen.2016.03.002
Autor:
Claudio Stefanelli, Silvia Cetrullo, Daniela Platano, Manuela Minguzzi, Giovanni Trisolino, Flavio Flamigni, Rosa Maria Borzì, Annalisa Facchini, Andrea Facchini, Stefania D'Adamo, Serena Guidotti, Giuseppe Filardo
Publikováno v:
Amino Acids. 46:717-728
The first step in skeleton development is the condensation of mesenchymal precursors followed by any of two different types of ossification, depending on the type of bone segment: in intramembranous ossification, the bone is deposed directly in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520bf0097008175d67a24736e7fc18e8
https://doi.org/10.1007/s00726-013-1607-9
https://doi.org/10.1007/s00726-013-1607-9
Different sources of mesenchymal stromal cells can be considered for regenerative medicine applications. Here we analyzed human adipose-derived stromal cells from infrapatellar fat pad (IFPSC) of osteoarthritis patients, representing a very interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::54ab7fc2669d63fe6c3de91425ee4eda
http://hdl.handle.net/11585/590559
http://hdl.handle.net/11585/590559
Publikováno v:
Osteoarthritis and cartilage. 25(4)
Summary Objective Nutraceutical compounds, such as hydroxytyrosol (HT), have been found to exert protective effects in osteoarthritis (OA) by affecting a variety of key molecular and cellular processes in chondrocytes. However, to our knowledge, no r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4878c98b0d4e98cb504dd2a9bbdff057
https://pubmed.ncbi.nlm.nih.gov/27914878
https://pubmed.ncbi.nlm.nih.gov/27914878