Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Serena Giannelli"'
Autor:
Giorgia Maria Ferlazzo, Anna Maria Gambetta, Sonia Amato, Noemi Cannizzaro, Silvia Angiolillo, Mattia Arboit, Linda Diamante, Elena Carbognin, Patrizia Romani, Federico La Torre, Elena Galimberti, Florian Pflug, Mirko Luoni, Serena Giannelli, Giuseppe Pepe, Luca Capocci, Alba Di Pardo, Paola Vanzani, Lucio Zennaro, Vania Broccoli, Martin Leeb, Enrico Moro, Vittorio Maglione, Graziano Martello
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG-repeat expansions in the huntingtin (HTT) gene. The resulting mutant HTT (mHTT) protein induces toxicity and cell death via multiple mechanisms and no effective therap
Externí odkaz:
https://doaj.org/article/c1ac1fcec269480f96fa0a3e4fd588a3
Autor:
Erica Staurenghi, Gabriella Testa, Valerio Leoni, Rebecca Cecci, Lucrezia Floro, Serena Giannelli, Eugenio Barone, Marzia Perluigi, Gabriella Leonarduzzi, Barbara Sottero, Paola Gamba
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 435 (2024)
Down syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer’s disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is
Externí odkaz:
https://doaj.org/article/f196c69f618141d8887f99601ff9edc1
Autor:
Nicholas Valassina, Simone Brusco, Alessia Salamone, Linda Serra, Mirko Luoni, Serena Giannelli, Simone Bido, Luca Massimino, Federica Ungaro, Pietro Giuseppe Mazzara, Patrizia D’Adamo, Gabriele Lignani, Vania Broccoli, Gaia Colasante
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dravet syndrome is a devastating epileptic encephalopathy caused by Scn1a gene haploinsufficiency. Exploiting a novel knock-in mouse model, here the authors show that restoring Scn1a expression after symptom onset is sufficient to rescue main phenoty
Externí odkaz:
https://doaj.org/article/32b901a6fa9f4ced99af59fcfd13679d
Autor:
Gabriella Testa, Serena Giannelli, Barbara Sottero, Erica Staurenghi, Giorgio Giaccone, Paola Caroppo, Paola Gamba, Gabriella Leonarduzzi
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 631 (2023)
Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degenerati
Externí odkaz:
https://doaj.org/article/41ceca56dce946fd9bfd664e232ec26a
Autor:
Anna Cozzi, Daniel I. Orellana, Paolo Santambrogio, Alicia Rubio, Cinzia Cancellieri, Serena Giannelli, Maddalena Ripamonti, Stefano Taverna, Giulia Di Lullo, Ermanna Rovida, Maurizio Ferrari, Gian Luca Forni, Chiara Fiorillo, Vania Broccoli, Sonia Levi
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 832-846 (2019)
Summary: Neuroferritinopathy (NF) is a movement disorder caused by alterations in the L-ferritin gene that generate cytosolic free iron. NF is a unique pathophysiological model for determining the direct consequences of cell iron dysregulation. We es
Externí odkaz:
https://doaj.org/article/1a80b9ac5a774715806543d0e61b3993
Autor:
Erica Staurenghi, Valerio Leoni, Marco Lo Iacono, Barbara Sottero, Gabriella Testa, Serena Giannelli, Gabriella Leonarduzzi, Paola Gamba
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2168 (2022)
The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis. Being astrocytes the main producers o
Externí odkaz:
https://doaj.org/article/b095b2435a404d40ac4eda8ffadbc6ae
Autor:
Erica Staurenghi, Valentina Cerrato, Paola Gamba, Gabriella Testa, Serena Giannelli, Valerio Leoni, Claudio Caccia, Annalisa Buffo, Wendy Noble, Beatriz Gomez Perez-Nievas, Gabriella Leonarduzzi
Publikováno v:
Redox Biology, Vol 39, Iss , Pp 101837- (2021)
Among Alzheimer's disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports the role of reactive astrocytes as mediators of changes in neurons,
Externí odkaz:
https://doaj.org/article/f2828f617de545a1ae710d9a775e594c
Autor:
Mirko Luoni, Serena Giannelli, Marzia Tina Indrigo, Antonio Niro, Luca Massimino, Angelo Iannielli, Laura Passeri, Fabio Russo, Giuseppe Morabito, Piera Calamita, Silvia Gregori, Benjamin Deverman, Vania Broccoli
Publikováno v:
eLife, Vol 9 (2020)
Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its
Externí odkaz:
https://doaj.org/article/6e839a611ea54772b2aeedcb0e414d33
Autor:
Gabriella Testa, Erica Staurenghi, Serena Giannelli, Simona Gargiulo, Michela Guglielmotto, Massimo Tabaton, Elena Tamagno, Paola Gamba, Gabriella Leonarduzzi
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 423-431 (2018)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them
Externí odkaz:
https://doaj.org/article/22c9b1cba0444471aaea76f33f06d0b8
Autor:
Erica Staurenghi, Serena Giannelli, Gabriella Testa, Barbara Sottero, Gabriella Leonarduzzi, Paola Gamba
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 1890 (2021)
In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation, neur
Externí odkaz:
https://doaj.org/article/68f0c1d2a38f42c8b6136a92f5d0922d