T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Autor: Alfie R. Wearn, Volkan Nurdal, Esther Saunders-Jennings, Michael J. Knight, Hanna K. Isotalus, Serena Dillon, Demitra Tsivos, Risto A. Kauppinen, Elizabeth J. Coulthard

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2020)

Abstract Background Early Alzheimer’s disease (AD) diagnosis is vital for development of disease-modifying therapies. Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. Thes

Externí odkaz: https://doaj.org/article/fac9fb199eca4558b1f6aa3f07c85b88

The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory

Autor: Catherine Pennington, Margaret Newson, Bryony McCann, Serena Dillon, Anna I. Shiel, Michael J. Knight, Myra E. Conway, Risto A. Kauppinen, Demitra Tsivos, Elizabeth Coulthard

Publikováno v: Dillon, S E, Tsivos, D, Knight, M, Mccann, B, Pennington, C, Shiel, A I, Conway, M E, Newson, M A, Kauppinen, R A & Coulthard, E J 2017, ' The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory ', Scientific Reports, vol. 7, 14069 . https://doi.org/10.1038/s41598-017-13853-8
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Dillon, S, Tsivos, D, Knight, M, McCann, B, Pennington, C, Newson, M, Conway, M, Shiel, A, Kauppinen, R & Coulthard, L 2017, ' The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory. ', Scientific Reports, vol. 7, 14069 . https://doi.org/10.1038/s41598-017-13853-8
Scientific Reports

Both recognition of familiar objects and pattern separation, a process that orthogonalises overlapping events, are critical for effective memory. Evidence is emerging that human pattern separation requires dentate gyrus. Dentate gyrus is intimately c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccbd0d1db863bf95da51de08c534db5
https://hdl.handle.net/20.500.11820/70fdb076-1e3a-4b2a-87f4-7bf22fd92bb1

Quantitative T2 mapping of white matter: applications for ageing and cognitive decline

Autor: Michael J, Knight, Bryony, McCann, Demitra, Tsivos, Serena, Dillon, Elizabeth, Coulthard, Risto A, Kauppinen

Publikováno v: Physics in Medicine and Biology

In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd4bb8168971a971e00e3e9a3885debd
https://pubmed.ncbi.nlm.nih.gov/27384985