Functional analysis of three new alpha-thalassemia deletions involving MCS-R2 reveals the presence of an additional enhancer element in the 5' boundary region.

Autor: Serena Capasso, Giovanna Cardiero, Gennaro Musollino, Romeo Prezioso, Rosario Testa, Sabrina Dembech, Giulio Piluso, Vincenzo Nigro, F Anna Digilio, Giuseppina Lacerra

Publikováno v: PLoS Genetics, Vol 19, Iss 5, p e1010727 (2023)

We report three novel deletions involving the Multispecies Conserved Sequences (MCS) R2, also known as the Major Regulative Element (MRE), in patients showing the α-thalassemia phenotype. The three new rearrangements showed peculiar positions of the

Externí odkaz: https://doaj.org/article/4161edcfd88b435daf3d27b383c55c42

Glycosphingolipid metabolic reprogramming drives neural differentiation

Autor: Alberto Luini, Riccardo Rizzo, Salvatore Fioriniello, Vittorio Maglione, Ilaria Granata, Kei Hori, Maurizio D'Esposito, Mario Rosario Guarracino, Serena Capasso, Mikio Hoshino, Domenico Russo, Ludger Johannes, Giovanni D'Angelo, Floriana Della Ragione, Francesco Scalabrì, Eiji Sugiyama, Lucia Sticco, Mitsutoshi Setou, Gian Carlo Bellenchi, Roberto De Gregorio

Publikováno v: EMBO journal
37 (2017): e97674. doi:10.15252/embj.201797674
info:cnr-pdr/source/autori:Russo, Domenico; Della Ragione, Floriana; Rizzo, Riccardo; Sugiyama, Eiji; Scalabrì, Francesco; Hori, Kei; Capasso, Serena; Sticco, Lucia; Fioriniello, Salvatore; De Gregorio, Roberto; Granata, Ilaria; Guarracino, Mario R.; Maglione, Vittorio; Johannes, Ludger; Bellenchi, Gian Carlo; Hoshino, Mikio; Setou, Mitsutoshi; D'Esposito, Maurizio; Luini, Alberto; D'Angelo, Giovanni/titolo:Glycosphingolipid metabolic reprogramming drives neural differentiation/doi:10.15252%2Fembj.201797674/rivista:EMBO journal (Print)/anno:2017/pagina_da:e97674/pagina_a:/intervallo_pagine:e97674/volume:37

Neural development is accomplished by differentiation events leading to metabolic reprogramming. Glycosphingolipid metabolism is reprogrammed during neural development with a switch from globo‐ to ganglio‐series glycosphingolipid production. Fail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867d9fe9a818fc622d7426da594e6da0
https://pubmed.ncbi.nlm.nih.gov/29572242

Molecular mechanism of GOLPH3 mediated oncogenesis: from Golgi maturation to cell proliferation?

Autor: Riccardo Rizzo Serena Capasso Altea Alfe Seetharaman Parashuraman Giovanni D'Angelo & Alberto Luini

Publikováno v: ESF-EMBO Symposium Cell Polarity and Membrane Trafficking, Polonia Castle in Pultusk, Poland, 10 to 15 May 2014.
info:cnr-pdr/source/autori:Riccardo Rizzo Serena Capasso Altea Alfe Seetharaman Parashuraman Giovanni D'Angelo & Alberto Luini/congresso_nome:ESF-EMBO Symposium Cell Polarity and Membrane Trafficking/congresso_luogo:Polonia Castle in Pultusk, Poland/congresso_data:10 to 15 May 2014./anno:2014/pagina_da:/pagina_a:/intervallo_pagine
EMBO Workshop Cellular imaging of lipids, Vico Equense, Italy, 2-6 June 2014 in
info:cnr-pdr/source/autori:Riccardo Rizzo Serena Capasso Altea Alfe Seetharaman Parashuraman Giovanni D'Angelo & Alberto Luini/congresso_nome:EMBO Workshop Cellular imaging of lipids/congresso_luogo:Vico Equense, Italy/congresso_data:2-6 June 2014 in/anno:2014/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7f3a4ed07eba2bf14b6fd2dc61e54c23
http://www.cnr.it/prodotto/i/294413

Glycosphingolipids: synthesis and functions

Autor: Giovanni D'Angelo, Lucia Sticco, Domenico Russo, Serena Capasso

Publikováno v: FEBS journal. S (Online) 280 (2013): 6338–6353. doi:10.1111/febs.12559
info:cnr-pdr/source/autori:D'Angelo G, Capasso S, Sticco L, Russo D./titolo:Glycosphingolipids: synthesis and functions./doi:10.1111%2Ffebs.12559/rivista:FEBS journal. S (Online)/anno:2013/pagina_da:6338/pagina_a:6353/intervallo_pagine:6338–6353/volume:280

Glycosphingolipids (GSLs) comprise a heterogeneous group of membrane lipids formed by a ceramide backbone covalently linked to a glycan moiety. Hundreds of different glycans can be linked to tens of different ceramide molecules, giving rise to an ast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d5586c741a06de855a16cc4701f0a0

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans ‐Golgi network

Autor: Maarit Hölttä-Vuori, Josse van Galen, Angelika Hausser, Serena Capasso, Giovanni D'Angelo, Gabriele Turacchio, Vivek Malhotra, Domenico Russo, Lucia Sticco, Seetharaman Parashuraman, Marinella Pirozzi, Isabelle Riezman, Howard Riezman, Elina Ikonen, Riccardo Rizzo, Nina A. Dathan, Chiara Luberto, Alberto Luini, Felix Campelo

Publikováno v: EMBO Journal, Vol. 36, No 12 (2017) pp. 1736-1754
EMBO journal (Online) Volume 36, (2017). doi:10.15252/embj.201696048
info:cnr-pdr/source/autori:Serena Capasso, Lucia Sticco, Riccardo Rizzo, Marinella Pirozzi, Domenico Russo, Nina A Dathan, Felix Campelo, Josse van Galen, Maarit Hölttä-Vuori, Gabriele Turacchio, Angelika Hausser, Vivek Malhotra, Isabelle Riezman, Howard Riezman, Elina Ikonen, Chiara Luberto, Seetharaman Parashuraman, Alberto Luini, Giovanni D'Angelo/titolo:Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network/doi:10.15252%2Fembj.201696048/rivista:EMBO journal (Online)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:Volume 36

Sphingolipids are membrane lipids globally required for eukaryotic life. The sphingolipid content varies among endomembranes with pre‐ and post‐Golgi compartments being poor and rich in sphingolipids, respectively. Due to this different sphingoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fd34b81b77d3a08045e4ec248114a4
https://infoscience.epfl.ch/record/265307