Liquid Lipids Act as Polymorphic Modifiers of Tristearin-Based Formulations Produced by Melting Technologies

Autor: Serena Bertoni, Nadia Passerini, Beatrice Albertini

Publikováno v: Pharmaceutics, Vol 13, Iss 7, p 1089 (2021)

Despite the growing interest in lipid-based formulations, their polymorphism is still a challenge in the pharmaceutical industry. Understanding and controlling the polymorphic behavior of lipids is a key element for achieving the quality and preventi

Externí odkaz: https://doaj.org/article/b11a58bf26fe4156ab83c53dd3f1563d

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

Autor: Serena Bertoni, Beatrice Albertini, Nadia Passerini

Publikováno v: Molecules, Vol 24, Iss 19, p 3471 (2019)

The low and variable oral bioavailability of poorly water soluble drugs remains a major concern for the pharmaceutical industry. Spray congealing is an emerging technology for the production of solid dispersion to enhance the bioavailability of poorl

Externí odkaz: https://doaj.org/article/d32e8b988acd497bbcca140e687e14d2

Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection

Autor: Serena Bertoni, Nadia Passerini, Beatrice Albertini, Manuela Bartolini, Cecilia Prata, Daniele Tedesco

Publikováno v: Molecular Pharmaceutics
Molecular pharmaceutics
17 (2020): 3609–3621. doi:10.1021/acs.molpharmaceut.0c00666
info:cnr-pdr/source/autori:Bertoni, Serena; Tedesco, Daniele; Bartolini, Manuela; Prata, Cecilia; Passerini, Nadia; Albertini, Beatrice/titolo:Solid Lipid Microparticles for Oral Delivery of Catalase: Focus on the Protein Structural Integrity and Gastric Protection/doi:10.1021%2Facs.molpharmaceut.0c00666/rivista:Molecular pharmaceutics (Print)/anno:2020/pagina_da:3609/pagina_a:3621/intervallo_pagine:3609–3621/volume:17

Protein inactivation either during the production process or along the gastrointestinal tract is the major problem associated with the development of oral delivery systems for biological drugs. This work presents an evaluation of the structural integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d29a44bce62a0231957e105f895d555
https://doi.org/10.1021/acs.molpharmaceut.0c00666

Solvent-free fabrication of biphasic lipid-based microparticles with tunable structure

Autor: Serena Bertoni, Beatrice Albertini, Joanna Ronowicz-Pilarczyk, Natalia Calonghi, Nadia Passerini

Publikováno v: Pharmaceutics
Pharmaceutics, Vol 14, Iss 54, p 54 (2022)
Pharmaceutics; Volume 14; Issue 1; Pages: 54

Lipid-based biphasic microparticles are generally produced by long and complex techniques based on double emulsions. In this study, spray congealing was used as a solvent-free fabrication method with improved processability to transform water-in-oil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd37f60c9d27ce61afd7fe00c56f8f0c
https://hdl.handle.net/11585/879363

Investigating the physicochemical properties of solid dispersions based on semicrystalline carriers: A case study with ketoprofen

Autor: Serena, Bertoni, Beatrice, Albertini, Nadia, Passerini

Publikováno v: International Journal of Pharmaceutics. 632:122576

Hydrophilic semicrystalline carriers represent an alternative to amorphous polymers due to their low melting temperature, useful for the production of solid dispersions (SDs) by melting-based technologies. This research aims to compare SDs of ketopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481064f41bc79642816b2730e7bf45de
https://doi.org/10.1016/j.ijpharm.2022.122576