Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure

Autor: Paola Maccioni, Paolo Flore, Mauro A M Carai, Claudia Mugnaini, Serena Pasquini, Federico Corelli, Gian Luigi Gessa, Giancarlo Colombo

Publikováno v: Frontiers in Psychiatry, Vol 1 (2010)

The present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-

Externí odkaz: https://doaj.org/article/d39ba341c29e479bad90e950ce18a379

Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

Autor: Nicola P. Caradonna, Serena Pasquini, Antonella Brizzi, Roger G. Pertwee, Federico Corelli, Maria Cristina De Rosa, Daniele Bolognini, Maria Grazia Cascio, Alessia Ligresti, Claudia Mugnaini, Vincenzo Di Marzo

Publikováno v: European Journal of Medicinal Chemistry. 58:30-43

Within our studies on structure-activity relationships of 4-quinolone-3-carboxamides as cannabinoid ligands, a new series of compounds characterized by a fluoro or phenylthio group at 7-position and different substituents at N1 and carboxamide nitrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180ee9bcc93cead764d274d0f6325dc5
https://doi.org/10.1016/j.ejmech.2012.09.035

1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands

Autor: Romano Silvestri, Mauro A.M. Carai, Ettore Novellino, Marco Allarà, Giuseppe La Regina, Francesco Piscitelli, Federico Corelli, Valerio Gatti, Serena Pasquini, Alessia Ligresti, Vincenzo Di Marzo, Antonella Brizzi, Giancarlo Colombo

Publikováno v: European journal of medicinal chemistry 46 (2011): 5641–5653.
info:cnr-pdr/source/autori:Piscitelli F, Ligresti A, La Regina G, Gatti V, Brizzi A, Pasquini S, Allarà M, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F, Silvestri R./titolo:1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands./doi:/rivista:European journal of medicinal chemistry/anno:2011/pagina_da:5641/pagina_a:5653/intervallo_pagine:5641–5653/volume:46
European journal of medicinal chemistry (2011).
info:cnr-pdr/source/autori:Piscitelli F, Ligresti A, La Regina G, Gatti V, Brizzi A, Pasquini S, Allarà M, Carai MA, Novellino E, Colombo G, Di Marzo V, Corelli F, Silvestri R./titolo:1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB(1) or CB(2) receptor ligands./doi:/rivista:European journal of medicinal chemistry/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume

New 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as cannabinoid (CB) receptor ligands. Compound 11 (CB(1)K(i) = 2.3 nM, CB(1) SI = 163.6) showed CB(1) receptor affinity and selectivity superior to Rimonabant and AM251. Acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5982e44a06dd7116689242a762c4e562
https://doi.org/10.1016/j.ejmech.2011.09.037

Rapid Combinatorial Access to a Library of 1,5-Disubstituted-3-indole-N-alkylacetamides as CB2 Receptor Ligands

Autor: Federico Corelli, Serena Pasquini, Alessia Ligresti, Claudia Mugnaini, Vincenzo Di Marzo, Antonella Brizzi, Chiara Ghiron

Publikováno v: Journal of combinatorial chemistry 11 (2009): 795–798. doi:10.1021/cc9000955
info:cnr-pdr/source/autori:Pasquini S; Mugnaini C; Brizzi A; Ligresti A; Di Marzo V; Ghiron C; Corelli F/titolo:Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands/doi:10.1021%2Fcc9000955/rivista:Journal of combinatorial chemistry/anno:2009/pagina_da:795/pagina_a:798/intervallo_pagine:795–798/volume:11

In our research program on new cannabinoid receptor modulators,9-11 we decided to investigate the possibility to identify novel CB2 ligands starting from commercially available 5-hydroxyindole-3-acetic acid (Figure 2). This scaffold offers three poin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48138b69c506875e1d3743fbd775d25
https://doi.org/10.1021/cc9000955

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

Autor: Federico Corelli, Mats Larhed, Alejandro Trejos, Zeger Debyser, Claudia Mugnaini, Cristina Tintori, Myriam Witvrouw, Serena Pasquini, Maurizio Botta, Martine Michiels, Riina K Arvela, Frauke Christ

Publikováno v: Journal of Medicinal Chemistry; Vol 51
Journal of Medicinal Chemistry

A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally related to elvitegravir. Some of the new compounds proved to be abl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da1c4e0eed3c614b1db8e3b3d56362a