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Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease.

Autor: Makhaeva GF; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia., Kovaleva NV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia., Rudakova EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia., Boltneva NP; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia., Lushchekina SV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Astakhova TY; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Timokhina EN; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia., Serebryakova OG; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia., Shchepochkin AV; Institute of Organic Synthesis, Russian Academy of Sciences, Yekaterinburg, Russia.; Department of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, Russia., Averkov MA; Institute of Organic Synthesis, Russian Academy of Sciences, Yekaterinburg, Russia.; Department of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, Russia., Utepova IA; Institute of Organic Synthesis, Russian Academy of Sciences, Yekaterinburg, Russia.; Department of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, Russia., Demina NS; Institute of Organic Synthesis, Russian Academy of Sciences, Yekaterinburg, Russia., Radchenko EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Palyulin VA; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Fisenko VP; Department of Pharmacology of the Institute of Biodesign and Complex System Modeling of Biomedical Science & Technology Park of Sechenov I.M., First Moscow State Medical University, Moscow, Russia., Bachurin SO; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia., Chupakhin ON; Institute of Organic Synthesis, Russian Academy of Sciences, Yekaterinburg, Russia.; Department of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, Russia., Charushin VN; Institute of Organic Synthesis, Russian Academy of Sciences, Yekaterinburg, Russia.; Department of Organic and Biomolecular Chemistry, Ural Federal University, Yekaterinburg, Russia., Richardson RJ; Department of Pharmacology of the Institute of Biodesign and Complex System Modeling of Biomedical Science & Technology Park of Sechenov I.M., First Moscow State Medical University, Moscow, Russia.; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United States.; Department of Neurology, University of Michigan, Ann Arbor, MI, United States.; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Aug 09; Vol. 14, pp. 1219980. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).

Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals.

Autor: Burgart YV; Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Science (IOS UB RAS), S. Kovalevskoi St., 22, 620108 Ekaterinburg, Russia., Elkina NA; Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Science (IOS UB RAS), S. Kovalevskoi St., 22, 620108 Ekaterinburg, Russia., Shchegolkov EV; Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Science (IOS UB RAS), S. Kovalevskoi St., 22, 620108 Ekaterinburg, Russia., Krasnykh OP; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Poly-Technic University, Komsomolsky Av., 29, 614990 Perm, Russia., Makhaeva GF; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Severny proezd 1, 142432 Chernogolovka, Russia., Triandafilova GA; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Poly-Technic University, Komsomolsky Av., 29, 614990 Perm, Russia., Solodnikov SY; Scientific and Educational Center for Applied Chemical-Biological Research, Perm National Research Poly-Technic University, Komsomolsky Av., 29, 614990 Perm, Russia., Boltneva NP; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Severny proezd 1, 142432 Chernogolovka, Russia., Rudakova EV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Severny proezd 1, 142432 Chernogolovka, Russia., Kovaleva NV; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Severny proezd 1, 142432 Chernogolovka, Russia., Serebryakova OG; Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Severny proezd 1, 142432 Chernogolovka, Russia., Ulitko MV; Institute of Natural Sciences and Mathematics, The Ural Federal University Named after the First President of Russia B. N. Yeltsin, Lenina Av., 51, 620083 Ekaterinburg, Russia., Borisevich SS; Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Science (IOS UB RAS), S. Kovalevskoi St., 22, 620108 Ekaterinburg, Russia., Gerasimova NA; Ural Research Institute for Dermatology, Venereology and Immunopathology, Shcherbakova St., 8, 620076 Ekaterinburg, Russia., Evstigneeva NP; Ural Research Institute for Dermatology, Venereology and Immunopathology, Shcherbakova St., 8, 620076 Ekaterinburg, Russia., Kozlov SA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya St., 16/10, 117997 Moscow, Russia., Korolkova YV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya St., 16/10, 117997 Moscow, Russia., Minin AS; Institute of Natural Sciences and Mathematics, The Ural Federal University Named after the First President of Russia B. N. Yeltsin, Lenina Av., 51, 620083 Ekaterinburg, Russia.; M.N. Mikheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences, S. Kovalevskoi 18, 620108 Ekaterinburg, Russia., Belousova AV; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Pervomayskaya 106, 620108 Ekaterinburg, Russia., Mozhaitsev ES; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, 9 Lavrentiev Avenue, 630090 Novosibirsk, Russia., Klabukov AM; Smorodintsev Research Institute of Influenza of the Ministry of Health of the Russian Federation, 15/17 prof. Popov Street, 197376 Saint-Petersburg, Russia., Saloutin VI; Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Science (IOS UB RAS), S. Kovalevskoi St., 22, 620108 Ekaterinburg, Russia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 21; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 21.

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease.

Autor: Grishchenko MV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia., Makhaeva GF; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia., Burgart YV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia., Rudakova EV; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia., Boltneva NP; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia., Kovaleva NV; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia., Serebryakova OG; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia., Lushchekina SV; Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Russia.; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia., Astakhova TY; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia., Zhilina EF; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia., Shchegolkov EV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia., Richardson RJ; Departments of Environmental Health Sciences and Neurology, University of Michigan, 48109, Ann Arbor, MI, USA.; Center for Computational Medicine and Bioinformatics, University of Michigan, 48109, Ann Arbor, MI, USA., Saloutin VI; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, 620990, Ekaterinburg, Russia.

Publikováno v: ChemMedChem [ChemMedChem] 2022 May 18; Vol. 17 (10), pp. e202200080. Date of Electronic Publication: 2022 Mar 23.

Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.

Autor: Makhaeva GF; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Lushchekina SV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia; Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow, 119334, Russia., Boltneva NP; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Serebryakova OG; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Kovaleva NV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Rudakova EV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Elkina NA; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Ekaterinburg, 620990, Russia., Shchegolkov EV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Ekaterinburg, 620990, Russia., Burgart YV; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Ekaterinburg, 620990, Russia., Stupina TS; Institute of Problems of Chemical Physics Russian Academy of Sciences, Chernogolovka, 142432, Russia., Terentiev AA; Institute of Problems of Chemical Physics Russian Academy of Sciences, Chernogolovka, 142432, Russia., Radchenko EV; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Palyulin VA; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia; Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia., Saloutin VI; Postovsky Institute of Organic Synthesis, Urals Branch of Russian Academy of Sciences, Ekaterinburg, 620990, Russia., Bachurin SO; Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia., Richardson RJ; Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA; Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: rjrich@umich.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2021 Jun 05; Vol. 218, pp. 113385. Date of Electronic Publication: 2021 Mar 15.