Trimethylamine-N-oxide (TMAO) Selectively Disrupts Endothelium-Dependent Hyperpolarization-Type Relaxations in a Time-Dependent Manner in Rat Superior Mesenteric Artery

Autor: Abdelrahman Hamad, Serdar Uma, Melike Hacer Ozkan

Publikováno v: Biologicalpharmaceutical bulletin. 44(9)

The vascular action of trimethylamine-N-oxide (TMAO)-the gut microbiota-derived metabolite-in contributing cardiovascular disease is a controversial topic. A recent study has shown that acute exposure of TMAO at moderate concentrations inhibits endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b922502bc57c09179dfdeda753436fa
https://pubmed.ncbi.nlm.nih.gov/34471050

Efeito de 5-hidroxitriptofano no edema de pata de camundongo induzido por carragenina

Autor: Gokçen TELLI, Inci KAZKAYASI, Serdar UMA

Publikováno v: Revista de Nutrição v.34 2021
Revista de Nutrição
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
Revista de Nutrição, Volume: 34, Article number: e200119, Published: 02 JUN 2021
Revista de Nutrição, Vol 34 (2021)

Objective 5-Hydroxytryptophan is the precursor compound of serotonin biosynthesis. The oral absorption of 5-Hydroxytryptophan is close to 100% and, unlike serotonin, it crosses the blood-brain barrier freely. 5-Hydroxytryptophan has been used as a fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f71da31226abe57c1d19bbdaab3a19
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732021000100315

β-adrenergic Receptor Blocker ICI 118,551 Selectively Increases Intermediate-Conductance Calcium-Activated Potassium Channel (IKCa )-Mediated Relaxations in Rat Main Mesenteric Artery

Autor: Melike Hacer Ozkan, Serdar Uma

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 122:570-576

Endothelial IKCa and/or SKCa channels play an important role in the control of vascular tone by participating in endothelium-dependent relaxation. Whether β-AR antagonists, mainly used in hypertension, affect endothelial KCa channel function is unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::035c982c20eb91166594908abf232010
https://doi.org/10.1111/bcpt.12949

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

Autor: Ingemar Björkhem, Angel Cedazo-Minguez, Can Pekiner, Nihan Burul-Bozkurt, Muhammad-Al-Mustafa Ismail, Inci Kazkayasi, Cristina Parrado-Fernandez, Serdar Uma

Publikováno v: Neuroscience Letters. 633:174-181

Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83836aa8eece009bc196e3447d2b9ac8
https://doi.org/10.1016/j.neulet.2016.09.018

Electrical field stimulation (EFS)-induced relaxations turn into contractions upon removal of extracellular calcium in rat mesenteric artery

Autor: Elif Öztürk, Serdar Uma, Melike Hacer Ozkan

Publikováno v: Pharmacological Research. 70:60-65

In the present study, we aimed to examine the effect of blockade of L-type Ca(2+) channels (LTCC) and in addition the removal of extracellular Ca(2+), on EFS-induced relaxations in rings of rat mesenteric artery. EFS applied to the tissues precontrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23cb0f5a596665dd1f581886bff4157
https://doi.org/10.1016/j.phrs.2013.01.001