Physiologie et Physiopathologie du transport de chlore dans le canal collecteur rénal : caractérisation d'un modèle murin d'Acidose tubulaire rénale distale et Étude des mécanismes de régulation du canal ClC-Kb/Barttin

Autor: Serbin, Bettina

Le rein joue un rôle crucial dans de multiples processus biologiques, tels que le maintien de l’homéostasie acide-base et de la balance sodée. Le transport de chlore dans le néphron distal est un élément majeur de ces deux fonctions physiolog

Externí odkaz: http://www.theses.fr/2016PA066213/document

Physiology and Pathophysiology of the chloride transport in renal collecting duct : characterization of a mouse model of distal renal tubular acidosis and Study of the mechanisms of regulation of ClC-Kb/Barttin channel

Autor: Serbin, Bettina

Publikováno v: Physiologie [q-bio.TO]. Université Pierre et Marie Curie-Paris VI, 2016. Français. ⟨NNT : 2016PA066213⟩
Physiologie [q-bio.TO]. Université Pierre et Marie Curie-Paris VI, 2016. Français. 〈NNT : 2016PA066213〉

Kidney plays a major role in several biological fonctions as sodium balance or acid-base homeostasis. Chloride transport in the distal nephron is a key element of these two processes. During my thesis, i have worked on two projects related to physiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bd5ab16c9546529cf6fa6a1a66370f1e
https://tel.archives-ouvertes.fr/tel-01596700/document

Intercalated Cell Depletion and Vacuolar H + -ATPase Mistargeting in an Ae1 R607H Knockin Model

Autor: Francesco Trepiccione, Seth L. Alper, Nicolas Picard, Emmanuelle Cordat, A.K.M. Shahid Ullah, Bettina Serbin, J. Christopher Hennings, Teodor G. Păunescu, Diane E. Capen, Dominique Eladari, Rizwan Mumtaz, Dennis Brown, Christian A. Hübner, Isabelle Mouro-Chanteloup, Rawad Lashhab, Carsten A. Wagner, Antje K. Huebner

Publikováno v: Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (5), pp.1507-1520. ⟨10.1681/ASN.2016020169⟩
Journal of the American Society of Nephrology, 2017, 28 (5), pp.1507-1520. ⟨10.1681/ASN.2016020169⟩
Journal of the American Society of Nephrology, American Society of Nephrology, 2016, 28, ⟨10.1681/ASN.2016020169⟩
Journal of the American Society of Nephrology, American Society of Nephrology, 2016, 28, 〈10.1681/ASN.2016020169〉

International audience; Distal nephron acid secretion is mediated by highly specialized type A intercalated cells (A-ICs), which contain vacuolar H +-ATPase (V-type ATPase)-rich vesicles that fuse with the apical plasma membrane on demand. Intra-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c15648b145cdbe5911d19c84c6daee
https://hal.archives-ouvertes.fr/hal-02322494