Výsledky vyhledávání - "Serban P. Georgescu"

Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function

Autor: Derek K. Kong, John M. Kyriakis, Serban P. Georgescu, Sandro Goruppi

Publikováno v: Autophagy. 6(5)

Through autophagy cells adapt to nutrient availability, recycle cellular material and eliminate toxic proteins and damaged cellular organelles. Dysregulation of autophagy is implicated in the pathogenesis of various diseases, including cancer, neurod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd68e6c4fdb2d9115859e8466dd8c04
https://pubmed.ncbi.nlm.nih.gov/28157434

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Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8

Autor: Richard D. Patten, Mark Aronovitz, Sandro Goruppi, John M. Kyriakis, Serban P. Georgescu, Juan L. Iovanna

Publikováno v: American Journal of Physiology-Cell Physiology. 301:C1046-C1056

Left ventricular remodeling, including the deposition of excess extracellular matrix, is key to the pathogenesis of heart failure. The stress-inducible transcriptional regulator p8 is increased in failing human hearts and is required both for agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b362378753b35e015614b699c6f80ac
https://doi.org/10.1152/ajpcell.00211.2011

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Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

Autor: Carla E. Cano, Juan L. Iovanna, Serban P. Georgescu, Mark Aronovitz, Sandro Goruppi, Derek K. Kong, Richard D. Patten, John M. Kyriakis

Publikováno v: Molecular Biology of the Cell

In this study, we investigate a role for p8 in autophagy in vitro and in vivo, by using p8 −/− mice. In both settings, silencing of p8 is associated with basal up-regulation of autophagy and apoptosis. In vivo, the hearts of p8 knockout mice deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ae5e9fae708c9a5df7ee86ae6bf657
https://doi.org/10.1091/mbc.e09-09-0818

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Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

Autor: Bo Wang, Timothy F. Osborne, Ho-Jin Park, Robert O. Blaustein, Yali Zhang, Ronglih Liao, C. Michael Welzig, Jonas B. Galper, Christopher Madias, Hitoshi Shimano, Mark Aronovitz, Richard D. Patten, Richard H. Karas, Ulrike Begley, Mark S. Link, Serban P. Georgescu, Herbert H. Van Tol, Chuang Du

Publikováno v: Journal of Clinical Investigation. 118:259-271

Parasympathetic stimulation of the heart, which provides protection from arrhythmias and sudden death, involves activation of the G protein-coupled inward rectifying K+ channel GIRK1/4 and results in an acetylcholine-sensitive K+ current, I KACh. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b94f1f51358817574c4d928421c832
https://doi.org/10.1172/jci32011

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Simvastatin potentiates tumor necrosis factor α-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA

Autor: Ho-Jin Park, Dongjiang Tang, Serban P. Georgescu, Andrew D. Hamilton, Jonas B. Galper, Said M. Sebti

Publikováno v: Life Sciences. 79:1484-1492

HMG-CoA reductase inhibitors (statins) are widely used in the treatment and prevention of atherosclerosis. Here we demonstrate that the HMG-CoA reductase inhibitor simvastatin potentiates TNFalpha-mediated apoptosis and TNFalpha signaling in human um

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0773f9a3d2049bf23ec5ff2cfa070139
https://doi.org/10.1016/j.lfs.2006.04.019

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Transforming Growth Factor β Regulates the Expression of the M2 Muscarinic Receptor in Atrial Myocytes via an Effect on RhoA and p190RhoGAP

Autor: Jonas B. Galper, Alexander G. Papageorge, Joey V. Barnett, Simone M. Ward, Jay S. Desgrosellier, Ho-Jin Park, Serban P. Georgescu, Xiaoli Zhuang

Publikováno v: Journal of Biological Chemistry. 281:19995-20002

Transforming growth factor beta (TGFbeta) signaling is involved in the development and regulation of multiple organ systems and cellular signaling pathways. We recently demonstrated that TGFbeta regulates the response of atrial myocytes to parasympat

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https://doi.org/10.1074/jbc.m513095200

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Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis

Autor: Serban P. Georgescu, Ho-Jin Park, Dequon Kong, Kristin L. Johnson, Jonas B. Galper, Yali Zhang

Publikováno v: Stem Cell Reviews. 2:93-101

Human umbilical vein endothelial cells (HUVECs) have played a major role as a model system for the study of the regulation of endothelial cell function and the role of the endothelium in the response of the blood vessel wall to stretch, shear forces,

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https://doi.org/10.1007/s12015-006-0015-x

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