Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Serban L. Ilca"'
Autor:
Eric Gibbs, Emily Klemm, David Seiferth, Arvind Kumar, Serban L. Ilca, Philip C. Biggin, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Glycine receptors (GlyR) are a critical postsynaptic component of spinal neurons. Here, the auhtors present cryo-EM structures of a heteromeric GlyR in the presence of an antagonist, agonist and agonist with a positive allosteric modulator.
Externí odkaz:
https://doaj.org/article/db781d0d4fdb4137a11e404a9029e982
Autor:
Max Renner, Wanwisa Dejnirattisai, Loïc Carrique, Itziar Serna Martin, Dimple Karia, Serban L. Ilca, Shu F. Ho, Abhay Kotecha, Jeremy R. Keown, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here, the authors provide cryo-EM structures of mature and immature Spondweni virus, defining the furin recognition site at high resolution, and identifying a lipid that binds E upon capsid maturation and is also present in Zika and Dengue virions.
Externí odkaz:
https://doaj.org/article/c1e60ed8086c474ea0ccecd7e38b5686
Autor:
Luigi De Colibus, Elina Roine, Thomas S. Walter, Serban L. Ilca, Xiangxi Wang, Nan Wang, Alan M. Roseman, Dennis Bamford, Juha T. Huiskonen, David I. Stuart
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Here, the authors present the cryo-EM structure of the archaeal virus SH1 at 3.8 Å resolution and show how the major capsid proteins assemble into hetero-hexamers, providing insights into the assembly process of this and related PRD1-adeno lineage v
Externí odkaz:
https://doaj.org/article/c49688e838814e378948c888e788bdd5
Autor:
Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen, David I. Stuart
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Foot-and-mouth disease virus binds αvβ6 integrin, via a conserved RGD motif in the flexible, exposed GH loop of capsid protein VP1, for cell entry. Here Kotechaet al.visualize this interaction with the VP1 GH loop extending away from the viral surf
Externí odkaz:
https://doaj.org/article/7cc85a0a325f47d7981c002ee69ab865
Autor:
Zhaoyang Sun, Kamel El Omari, Xiaoyu Sun, Serban L. Ilca, Abhay Kotecha, David I. Stuart, Minna M. Poranen, Juha T. Huiskonen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Double-shelled bacteriophage φ6 is a well-studied model system used to understand assembly of dsRNA viruses. Here the authors report a near-atomic resolution cryo-EM structure of φ6 and propose a model for the structural transitions occurring in th
Externí odkaz:
https://doaj.org/article/b16852baa490454d977d1b4fd2e495b0
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Double-stranded RNA (dsRNA) viruses package several RNA-dependent RNA polymerases (RdRp) together with their dsRNA genome into an icosahedral protein capsid known as the polymerase complex. This structure is highly conserved among dsRNA viru
Externí odkaz:
https://doaj.org/article/3ef5ba89c76241b08573477c9dba8a72
Autor:
Eugene Y.D. Chua, Joshua H. Mendez, Micah Rapp, Serban L. Ilca, Yong Zi Tan, Kashyap Maruthi, Huihui Kuang, Christina M. Zimanyi, Anchi Cheng, Edward T. Eng, Alex J. Noble, Clinton S. Potter, Bridget Carragher
Publikováno v:
Annual review of biochemistry. 91
Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for visualizing biological objects, which has been driven by advances across the entire pipeline. Developments in both single-particle analysis and in situ tomography ha
Autor:
Loic Carrique, Jonathan M. Grimes, Abhay Kotecha, Gavin R. Screaton, D. Karia, Serban L. Ilca, S.F. Ho, Juthathip Mongkolsapaya, J.R. Keown, Itziar Serna Martin, Wanwisa Dejnirattisai, Max Renner
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Flaviviruses such as Dengue (DENV) or Zika virus (ZIKV) assemble into an immature form within the endoplasmatic reticulum (ER), and are then processed by furin protease in the trans-Golgi. To better grasp maturation, we carry out cryo-EM reconstructi
Autor:
S.F. Ho, Serban L. Ilca, Loic Carrique, J.R. Keown, Itziar Serna Martin, Max Renner, Jonathan M. Grimes, Wanwisa Dejnirattisai, Abhay Kotecha, Gavin R. Screaton, Juthathip Mongkolsapaya, D. Karia
Mosquito-transmitted flaviviruses, such as Dengue virus (DENV) or Zika virus (ZIKV), are responsible for significant economic damage and human misery. In infected cells, flaviviruses first assemble into an immature form within the endoplasmatic retic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ddd1e3f23a95a1dab58bc1f5711845d
https://doi.org/10.1101/2020.06.07.138669
https://doi.org/10.1101/2020.06.07.138669
Autor:
Juha T. Huiskonen, Josué Gómez-Blanco, Vijay S. Reddy, José Miguel de la Rosa-Trevín, Ilona Rissanen, Serban L. Ilca, Vahid Abrishami, José María Carazo
Publikováno v:
Progress in Biophysics and Molecular Biology
Technological advances in transmission electron microscopes and detectors have turned cryogenic electron microscopy (cryo-EM) into an essential tool for structural biology. A commonly used cryo-EM data analysis method, single particle analysis, avera