Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Serban Ghiorghiu"'
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 151KB, Activity of AZD9291 and metabolites against cellular phospho-HER2 assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa7607663be25c4b92403b9d05a1b74
https://doi.org/10.1158/2159-8290.22532207.v1
https://doi.org/10.1158/2159-8290.22532207.v1
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 235KB, Activity of AZD9291 and metabolites against rare EGFR mutations using cellular phosphorylation assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae9b7c4ff971c9197748ea7ba30b12d
https://doi.org/10.1158/2159-8290.22532204
https://doi.org/10.1158/2159-8290.22532204
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 294KB, Phenotype and phosphorylation assay data for AZD9291 against lung cancer associated HER2 mutation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c701402276f050fac7f2f50b4f678c
https://doi.org/10.1158/2159-8290.22532201
https://doi.org/10.1158/2159-8290.22532201
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 107KB, Mass Spectrometry study showing covalent binding of AZD9291 to cysteine 797 in EGFR T790M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fee71280bb8e5903ad324190bd450d
https://doi.org/10.1158/2159-8290.22532210.v1
https://doi.org/10.1158/2159-8290.22532210.v1
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 312KB, Efficacy of AZD9291 in H3255, PC-9VanR and A431 xenograft models. Weight loss data for chronically dosed AZD9291 in PC-9 and H1975 xenograft models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754faf19a9b9f1fe62df9a5795c6cab6
https://doi.org/10.1158/2159-8290.22532195
https://doi.org/10.1158/2159-8290.22532195
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 470KB, Effect of AZD9291 and AZ5104 in transgenic models of EGFR-TKI sensitizing (C/L858R and C/ex19del) and T790M resistant (C/L+T) lung cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10f5fe0ea84a79486aa4e5b07fa2aed
https://doi.org/10.1158/2159-8290.22532192.v1
https://doi.org/10.1158/2159-8290.22532192.v1
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 182KB, Pharmacokinetic analysis of AZD9291, AZ5104 and AZ7550 total plasma concentrations vs time following single oral dose of 25mg/kg AZD9291 in mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4888b1e011dc46d7bdc6613099c05492
https://doi.org/10.1158/2159-8290.22532198.v1
https://doi.org/10.1158/2159-8290.22532198.v1
Autor:
William Pao, Malcolm R. Ranson, Dong-Wan Kim, Mireille Cantarini, Graham H.P. Richmond, Teresa Klinowska, Rachel Rowlinson, Katherine Al-Kadhimi, Peter Ballard, Hailing Jin, Jing Sun, Eiki Ichihara, Monica Red Brewer, Vivien N. Jacobs, Amar Rahi, Gareth Hughes, Martine J. Mellor, Richard A. Ward, M. Raymond V. Finlay, Jonathon P. Orme, Paula J. Spitzler, Caroline A. Nebhan, Cath Eberlein, Serban Ghiorghiu, Susan E. Ashton, Darren A.E. Cross
PDF file - 89KB, Additional biochemical and cellular profiling data for AZD9291 and metabolites.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d76504690708d6ace2f513b9760d1d9
https://doi.org/10.1158/2159-8290.22532189.v1
https://doi.org/10.1158/2159-8290.22532189.v1
Autor:
Jiabu Ye, Binbing Yu, Helen Mann, Antony Sabin, Zsolt Szijgyarto, David Wright, Pralay Mukhopadhyay, Cristian Massacesi, Serban Ghiorghiu, Renee Iacona
Publikováno v:
Journal of Data Science. :1-18
We assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on the statistical analysis of time-to-event outcomes in late-phase oncology trials. Using a simulated case study that mimics a Phase III ongoing trial during the pandemic, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f68d1e51b7c7b18772990f366b066d15
https://doi.org/10.6339/22-jds1079
https://doi.org/10.6339/22-jds1079
Autor:
Thomas John, Yuichiro Ohe, Yuri Rukazenkov, Naoyuki Nogami, Serban Ghiorghiu, Daniel Stetson, Takayasu Kurata, Chee Khoon Lee, Pasi A. Jänne, James Chih-Hsin Yang, Aleksandra Markovets, Suresh S. Ramalingam, Helen Mann, Kenneth S. Thress, J. Carl Barrett, Dong Wan Kim
Publikováno v:
Journal of Clinical Oncology. 36:841-849
Purpose The AURA study ( ClinicalTrials.gov identifier: NCT01802632) included two cohorts of treatment-naïve patients to examine clinical activity and safety of osimertinib (an epidermal growth factor receptor [EGFR] –tyrosine kinase inhibitor sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7dcf3de5e32d69186af139e920b6f32
https://doi.org/10.1200/jco.2017.74.7576
https://doi.org/10.1200/jco.2017.74.7576