Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Seray Demir"'
Autor:
Hasan Hüseyin Hendek, Alina Blusch, Neele Heitmann, Sarah Oberhagemann, Seray Demir, Xiomara Pedreiturria, Ralf Gold, Simon Faissner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract So far, only a small number of medications are effective in progressive multiple sclerosis (MS). The sphingosine-1-phosphate-receptor (S1PR)-1,5 modulator siponimod, licensed for progressive MS, is acting both on peripheral immune cells and
Externí odkaz:
https://doaj.org/article/893365440976485ea1a55231324646ed
Autor:
Ümmügülsüm Koc, Steffen Haupeltshofer, Katharina Klöster, Seray Demir, Ralf Gold, Simon Faissner
Publikováno v:
Cells, Vol 12, Iss 4, p 542 (2023)
Background: Glatiramer acetate (GA) is a well-established treatment option for patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis (MS) with few side effects. The double transgenic mouse model spontaneous opticospi
Externí odkaz:
https://doaj.org/article/060012dc65514c02bc6ad39e7421ccf8
Autor:
Lisa Thiele née Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese, Andrew Chan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-9 (2020)
Abstract Background The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribin
Externí odkaz:
https://doaj.org/article/7192c5f5a49342408e5e811a46b98eff
Autor:
Thomas Grüter, Nuwin Mohamad, Niklas Rilke, Alina Blusch, Melissa Sgodzai, Seray Demir, Xiomara Pedreiturria, Katharina Lemhoefer, Barbara Gisevius, Aiden Haghikia, Anna Lena Fisse, Jeremias Motte, Ralf Gold, Kalliopi Pitarokoili
Publikováno v:
Proceedings of the National Academy of Sciences. 120
In inflammatory neuropathies, oxidative stress results in neuronal and Schwann cell (SC) death promoting early neurodegeneration and clinical disability. Treatment with the short-chain fatty acid propionate showed a significant immunoregulatory and n
Autor:
Seray Demir, Andrew Chan, Kirsten Guse, Lisa Schrewe, Fred Lühder, Britta Engelhardt, Silvia Tietz, Dirk M. Hermann, Maximilian Pistor, Robert Hoepner, Jana Remlinger, Timothy Turner, Xiomara Pedreiturria, Anke Salmen, Stefan Wiese
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-9 (2020)
Journal of Neuroinflammation
Thiele née Schrewe, Lisa; Guse, Kirsten; Tietz, Silvia; Remlinger, Jana; Demir, Seray; Pedreiturria, Xiomara; Hoepner, Robert; Salmen, Anke; Pistor, Maximilian; Turner, Timothy; Engelhardt, Britta; Hermann, Dirk M; Lühder, Fred; Wiese, Stefan; Chan, Andrew (2020). Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis. Journal of neuroinflammation, 17(1), p. 9. BioMed Central 10.1186/s12974-019-1677-z
Journal of Neuroinflammation
Thiele née Schrewe, Lisa; Guse, Kirsten; Tietz, Silvia; Remlinger, Jana; Demir, Seray; Pedreiturria, Xiomara; Hoepner, Robert; Salmen, Anke; Pistor, Maximilian; Turner, Timothy; Engelhardt, Britta; Hermann, Dirk M; Lühder, Fred; Wiese, Stefan; Chan, Andrew (2020). Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis. Journal of neuroinflammation, 17(1), p. 9. BioMed Central 10.1186/s12974-019-1677-z
BackgroundThe multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribine, and mit
Publikováno v:
Journal of Neuroimmunology. 328:78-85
The murine anti-CD52 antibody, an equivalent of the humanized antibody alemtuzumab, which is successfully used in the treatment of multiple sclerosis, was used to explore a potential neuroprotective effect driven by immune cell derived brain-derived
Autor:
Andrew Chan, Maud Bagnoud, Seray Demir, Paul F. Worley, Farhad Ahmadi, Melissa Gresle, Holger M. Reichardt, Kirsten Guse, Lisa Schrewe, Maximilian Pistor, Helen Synn, Myriam Briner, Ralf Gold, Imke Metz, Anke Salmen, Helmut Butzkueven, Louis Laverick, Robert Hoepner, Fred Lühder
Publikováno v:
Hoepner, Robert; Bagnoud, Maud; Pistor, Maximilian; Salmen, Anke; Briner, Myriam; Synn, Helen; Schrewe, Lisa; Guse, Kirsten; Ahmadi, Farhad; Demir, Seray; Laverick, Louis; Gresle, Melissa; Worley, Paul; Reichardt, Holger Michael; Butzkueven, Helmut; Gold, Ralf; Metz, Imke; Lühder, Fred; Chan, Andrew (2019). Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis. Acta neuropathologica, 138(3), pp. 443-456. Springer-Verlag 10.1007/s00401-019-02018-8
Acta Neuropathologica
Acta Neuropathologica
The limited efficacy of glucocorticoids (GCs) during therapy of acute relapses in multiple sclerosis (MS) leads to long-term disability. We investigated the potential of vitamin D (VD) to enhance GC efficacy and the mechanisms underlying this VD/GC i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60fed6e5a2c39aac01cced7d660fbbd
Autor:
Marie Pierre Manitz, Simone Wachholz, Astrid Friebe, Georg Juckel, Seray Demir, Jennifer Plümper, Manuela Eßlinger, Martin Eisenacher, Maike Ahrens
Publikováno v:
Brain Research. 1636:172-182
The neuropathology of schizophrenia has been reported to be closely associated with microglial activation. In a previous study, using the prenatal PolyI:C schizophrenia animal model, we showed an increase in cell numbers and a reduction in microglial
Autor:
Stefanie Jörg, Denis A. Akkad, Anne Waschbisch, Nils Helge Schebb, Caroline May, Alexander Duscha, Stefan Kempa, Aiden Haghikia, Ralf Gold, Diana A. Grohme, Markus Kleinewietfeld, Jan Thöne, Johannes Berg, Annika I. Ostermann, András Balogh, Nicola Wilck, Dominik N. Müller, Anna Hammer, Seray Demir, Ralf A. Linker, Arndt Manzel, De-Hyung Lee
Publikováno v:
Immunity. 43(4):817-829
SummaryGrowing empirical evidence suggests that nutrition and bacterial metabolites might impact the systemic immune response in the context of disease and autoimmunity. We report that long-chain fatty acids (LCFAs) enhanced differentiation and proli
Autor:
Ralf Gold, Niels Kruse, Ralf A. Linker, Harald Neumann, Fred Lühder, Seray Demir, Michael Sendtner, Ines Siglienti, Ellen Gerhardt, De-Hyung Lee, Stefan Wiese
Publikováno v:
Brain. 133:2248-2263
Brain-derived neurotrophic factor plays a key role in neuronal and axonal survival. Brain-derived neurotrophic factor is expressed in the immune cells in lesions of experimental autoimmune encephalomyelitis and multiple sclerosis, thus potentially me