Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Seray Adams"'
Autor:
Seray Adams, Charles Teo, Kerrie L McDonald, Anna Zinger, Sonia Bustamante, Chai K Lim, Gayathri Sundaram, Nady Braidy, Bruce J Brew, Gilles J Guillemin
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112945 (2014)
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the e
Externí odkaz:
https://doaj.org/article/a0200add04b44100ad43f6621c4156d7
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14123 (2010)
Astrocytes have long been perceived only as structural and supporting cells within the central nervous system (CNS). However, the discovery that these glial cells may potentially express receptors capable of responding to endogenous neurotransmitters
Externí odkaz:
https://doaj.org/article/6615200495244446b1a7e848f5274e08
Autor:
Michael Platten, Wolfgang Wick, Gilles J. Guillemin, Helge B. Bode, Seray Adams, Tilman Ahrendt, Andreas von Deimling, Bernhard Radlwimmer, Christiane A. Opitz, Iris Oezen, Felix Sahm
PDF file - 100K, Subtype, age, gender and time to recurrence (where applicable for this study) of glioblastoma patients. GBM - glioblastoma; m - male; f - female.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a64bd7743e697c59e10639f39dc609
https://doi.org/10.1158/0008-5472.22397564
https://doi.org/10.1158/0008-5472.22397564
Publikováno v:
Handbook of Neurotoxicity ISBN: 9783031150791
Handbook of Neurotoxicity ISBN: 9781461458357
Handbook of Neurotoxicity ISBN: 9783030715199
Handbook of Neurotoxicity ISBN: 9781461458357
Handbook of Neurotoxicity ISBN: 9783030715199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b985183072095788e6b901703ffed1e
https://doi.org/10.1007/978-3-031-15080-7_149
https://doi.org/10.1007/978-3-031-15080-7_149
Autor:
Emily K. Don, David B. Lovejoy, Nicholas J. Cole, Chai K. Lim, Seray Adams, Gilles J. Guillemin, Kelly R. Jacobs, Gloria Castellano-Gonzalez
Publikováno v:
Neurotoxicity Research. 35:530-541
Upregulation of the kynurenine pathway (KP) of tryptophan metabolism is commonly observed in neurodegenerative disease. When activated, L-kynurenine (KYN) increases in the periphery and central nervous system where it is further metabolised to other
Autor:
Felix Sahm, Michael Platten, Gilles J. Guillemin, Bernhard Radlwimmer, Iris Oezen, Seray Adams, Christiane A. Opitz, Andreas von Deimling, Helge B. Bode, Tilman Ahrendt, Wolfgang Wick
Publikováno v:
Cancer Research. 73:3225-3234
Quinolinic acid is a product of tryptophan degradation and may serve as a precursor for NAD+, an important enzymatic cofactor for enzymes such as the DNA repair protein PARP. Pathologic accumulation of quinolinic acid has been found in neurodegenerat
Autor:
Nady Braidy, Seray Adams, Gilles J. Guillemin, Alban Bessesde, Charlie Teo, Bruce J. Brew, Ross Grant
Publikováno v:
Cancer Research. 72:5649-5657
Brain tumors are among the most common and most chemoresistant tumors. Despite treatment with aggressive treatment strategies, the prognosis for patients harboring malignant gliomas remains dismal. The kynurenine pathway (KP) is the principal route o
Autor:
Mari Konayagi, Gilles J. Guillemin, Charles Teo, Yiu To Yeung, Lenka Munoz, Nady Braidy, Nicole S. Bryce, Kerrie L. McDonald, Thomas Grewal, Seray Adams
Publikováno v:
Journal of Neuro-Oncology. 109:35-44
Increasing evidence suggests that an inflammatory microenvironment promotes invasion by glioblastoma (GBM) cells. Together with p38 mitogen-activated protein kinase (MAPK) activation being regarded as promoting inflammation, we hypothesized that elev
Publikováno v:
FEBS Journal. 277:368-382
Quinolinic acid (QUIN) excitotoxicity is mediated by elevated intracellular Ca(2+) levels, and nitric oxide-mediated oxidative stress, resulting in DNA damage, poly(ADP-ribose) polymerase (PARP) activation, NAD(+) depletion and cell death. We evaluat
Publikováno v:
International Journal of Tryptophan Research, Vol 2009, Iss 2, Pp 61-69 (2009)
International Journal of Tryptophan Research, Vol 2 (2009)
Scopus-Elsevier
Macquarie University
Europe PubMed Central
International Journal of Tryptophan Research, Vol 2, Pp 61-69 (2009)
International Journal of Tryptophan Research : IJTR
International Journal of Tryptophan Research, Vol 2 (2009)
Scopus-Elsevier
Macquarie University
Europe PubMed Central
International Journal of Tryptophan Research, Vol 2, Pp 61-69 (2009)
International Journal of Tryptophan Research : IJTR
The kynurenine pathway (KP) is a major route of L-tryptophan catabolism resulting in the production of the essential pyridine nucleotide nicotinamide adenine dinucleotide, (NAD+). Up-regulation of the KP during inflammation leads to the release of a