Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Serap, Erkek"'
Autor:
Perihan Yagmur Guneri-Sozeri, Gülden Özden-Yılmaz, Asli Kisim, Ece Cakiroglu, Aleyna Eray, Hamdiye Uzuner, Gökhan Karakülah, Devrim Pesen-Okvur, Serif Senturk, Serap Erkek-Ozhan
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
The transcription factors FRA1 and FLI1 regulate cell migration and cell junction organization genes in muscle-invasive bladder cancer, and loss of these factors reduces cancer cell invasion, pointing toward a therapeutic avenue.
Externí odkaz:
https://doaj.org/article/e4c1a871085b4d33bd8ef8066b1d2292
Autor:
Mazi, Fatma Aybuke, Cakiroglu, Ece, Uysal, Merve, Kalyoncu, Minenur, Demirci, Dilara, Sozeri, Perihan Yagmur Guneri, Yilmaz, Gulden Ozden, Ozhan, Serap Erkek, Senturk, Serif
Publikováno v:
In Cellular Signalling May 2023 105
Autor:
Lena Blümel, Nan Qin, Johannes Berlandi, Eunice Paisana, Rita Cascão, Carlos Custódia, David Pauck, Daniel Picard, Maike Langini, Kai Stühler, Frauke-Dorothee Meyer, Sarah Göbbels, Bastian Malzkorn, Max C. Liebau, João T. Barata, Astrid Jeibmann, Kornelius Kerl, Serap Erkek, Marcel Kool, Stefan M. Pfister, Pascal D. Johann, Michael C. Frühwald, Arndt Borkhardt, Guido Reifenberger, Claudia C. Faria, Ute Fischer, Martin Hasselblatt, Jasmin Bartl, Marc Remke
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-13 (2022)
Abstract Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4 proteins. Recent studies show that AT/RTs comprise three molecular subgroups, nam
Externí odkaz:
https://doaj.org/article/135ad632b2b8459392b5b46750bd8481
Autor:
Gülden Özden-Yılmaz, Busra Savas, Ahmet Bursalı, Aleyna Eray, Alirıza Arıbaş, Serif Senturk, Ezgi Karaca, Gökhan Karakülah, Serap Erkek-Ozhan
Publikováno v:
Cells, Vol 12, Iss 6, p 836 (2023)
Epigenetic deregulation is a critical theme which needs further investigation in bladder cancer research. One of the most highly mutated genes in bladder cancer is KDM6A, which functions as an H3K27 demethylase and is one of the MLL3/4 complexes. To
Externí odkaz:
https://doaj.org/article/6f40010068f14d7099c558314aeb9bfc
Autor:
Catherine Lee, Vasilisa A. Rudneva, Serap Erkek, Marc Zapatka, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Alexandra Garancher, Jessica M. Rusert, Ozlem Aksoy, Robin Lea, Helai P. Mohammad, Jianxun Wang, William A. Weiss, H. Leighton Grimes, Stefan M. Pfister, Paul A. Northcott, Robert J. Wechsler-Reya
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this intera
Externí odkaz:
https://doaj.org/article/3008cdc8884c4e79a131516d3e5463b0
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable across cell types, intra-T
Externí odkaz:
https://doaj.org/article/60bd32224a234a588850e5f4613b28d7
Autor:
Hye-Jung E. Chun, Pascal D. Johann, Katy Milne, Marc Zapatka, Annette Buellesbach, Naveed Ishaque, Murat Iskar, Serap Erkek, Lisa Wei, Basile Tessier-Cloutier, Jake Lever, Emma Titmuss, James T. Topham, Reanne Bowlby, Eric Chuah, Karen L. Mungall, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Michael D. Taylor, Daniela S. Gerhard, Steven J.M. Jones, Andrey Korshunov, Manfred Gessler, Kornelius Kerl, Martin Hasselblatt, Michael C. Frühwald, Elizabeth J. Perlman, Brad H. Nelson, Stefan M. Pfister, Marco A. Marra, Marcel Kool
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2338-2354.e7 (2019)
Summary: Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we a
Externí odkaz:
https://doaj.org/article/f387a818dece4658893038403fb02a1d
Autor:
Gizem Ozgun, Tutku Yaras, Nick Landman, Gökhan Karakülah, Maarten van Lohuizen, Serif Senturk, Serap Erkek Ozhan
Emerging evidence has highlighted the importance of targeting EZH2 in bladder cancer owing to the highly mutated nature of bladder cancers harboring mutations in chromatin regulatory genes opposing Polycomb-mediated repression. Besides, enhanced expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7d12fcd5bb3f99f5237922e5318621
https://doi.org/10.1101/2023.04.19.537500
https://doi.org/10.1101/2023.04.19.537500
Publikováno v:
Molecular Biology Reports. 49:3135-3147
Background Recent genome-wide studies revealed the molecular subtypes and mutational landscape of bladder cancer, which is the 10th most common cancer causing many deaths. ELF3 is one of the frequently mutated genes in bladder cancer with 14% alterat
Autor:
Fatma Aybuke Mazi, Ece Cakiroglu, Merve Uysal, Minenur Kalyoncu, Dilara Demirci, Perihan Yagmur Guneri Sozeri, Gulden Ozden Yilmaz, Serap Erkek Ozhan, Serif Senturk
Publikováno v:
Cellular Signalling. 105:110611
TGF-beta signaling mediates its biological effects by engaging canonical Smad proteins and crosstalking extensively with other signaling networks, including the NF-kB pathway. The paracaspase MALT1 is an intracellular signaling molecule essential for