Proteomic Profile of Endometrial Cancer: A Scoping Review.

Autor: Serambeque B; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal., Mestre C; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal., Hundarova K; Gynecology Service, Department of Gynecology, Obstetrics, Reproduction and Neonatology, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal., Marto CM; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.; Clinical Academic Centre of Coimbra (CACC), 3004-561 Coimbra, Portugal.; Univ Coimbra, Institute of Experimental Pathology, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Institute of Integrated Clinical Practice and Laboratory for Evidence-Based Sciences and Precision Dentistry, 3000-075 Coimbra, Portugal.; Univ Coimbra, Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), Advanced Production and Intelligent Systems (ARISE), 3030-788 Coimbra, Portugal., Oliveiros B; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.; Clinical Academic Centre of Coimbra (CACC), 3004-561 Coimbra, Portugal.; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO) and Laboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, 3004-531 Coimbra, Portugal., Gomes AR; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Chemical Engineering and Renewable Resources for Sustainability (CERES), Faculty of Pharmacy, Laboratory of Pharmaceutical Chemistry, 3000-548 Coimbra, Portugal., Teixo R; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal., Carvalho AS; iNOVA4Health, NOVA Medical School (NMS), Faculdade de Ciências Médicas (FCM), Universidade Nova de Lisboa, 1150-082 Lisboa, Portugal., Botelho MF; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.; Clinical Academic Centre of Coimbra (CACC), 3004-561 Coimbra, Portugal.; Univ Coimbra, Institute of Experimental Pathology, Faculty of Medicine, 3000-548 Coimbra, Portugal., Matthiesen R; iNOVA4Health, NOVA Medical School (NMS), Faculdade de Ciências Médicas (FCM), Universidade Nova de Lisboa, 1150-082 Lisboa, Portugal., Carvalho MJ; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.; Gynecology Service, Department of Gynecology, Obstetrics, Reproduction and Neonatology, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.; Clinical Academic Centre of Coimbra (CACC), 3004-561 Coimbra, Portugal.; Univ Coimbra, Universitary Clinic of Gynecology, Faculty of Medicine, 3004-561 Coimbra, Portugal., Laranjo M; Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, 3000-548 Coimbra, Portugal.; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), 3000-548 Coimbra, Portugal.; Clinical Academic Centre of Coimbra (CACC), 3004-561 Coimbra, Portugal.

Publikováno v: Biology [Biology (Basel)] 2024 Aug 01; Vol. 13 (8). Date of Electronic Publication: 2024 Aug 01.

AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells.

Autor: Lapa BS; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal., Costa MI; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal., Figueiredo D; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal., Jorge J; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal., Alves R; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal., Monteiro AR; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal., Serambeque B; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Institute of Biophysics, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal., Laranjo M; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal.; Institute of Biophysics, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal., Botelho MF; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal.; Institute of Biophysics, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal., Carreira IM; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal.; Cytogenetics and Genomics Laboratory, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal., Sarmento-Ribeiro AB; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal.; Hematology Service, Centro Hospitalar e Universitário de Coimbra (CHUC), 3000-061 Coimbra, Portugal., Gonçalves AC; Laboratory of Oncobiology and Hematology (LOH), University Clinics of Hematology and Oncology, Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Coimbra Institute for Clinical and Biomedical Research (iCBR), Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-061 Coimbra, Portugal.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 18; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 18.

43P Looking for therapeutic targets on the proteome profile of endometrial cancer stem cells

Autor: Laranjo, M., Mestre, C., Serambeque, B., Carvalho, A.S., Beck, H.C., Botelho, M.F., Carvalho, M.J., Matthiesen, R.

Publikováno v: In Annals of Oncology October 2023 34 Supplement 2:S200-S200

Application of Perinatal Derivatives on Oncological Preclinical Models: A Review of Animal Studies.

Autor: Teixo R; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal., Pires AS; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal., Pereira E; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal., Serambeque B; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal., Marques IA; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal., Laranjo M; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal., Mojsilović S; Group for Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, 11129 Belgrade, Serbia., Gramignoli R; Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.; Department of Pathology, Medicinsk Cancer Diagnostik, Karolinska University Hospital, 171 64 Huddinge, Sweden., Ponsaerts P; Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, 2610 Antwerp, Belgium., Schoeberlein A; Department of Obstetrics and Feto-Maternal Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.; Department for BioMedical Research (DBMR), University of Bern, 3012 Bern, Switzerland., Botelho MF; Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Institute of Biophysics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), 3000-548 Coimbra, Portugal.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 02; Vol. 23 (15). Date of Electronic Publication: 2022 Aug 02.

Ring-Fused meso -Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation.

Autor: Laranjo M; Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Centre of Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal., Pereira NAM; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Oliveira ASR; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Campos Aguiar M; Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Brites G; Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal., Nascimento BFO; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Serambeque B; Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Centre of Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Costa BDP; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Pina J; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Seixas de Melo JS; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Pineiro M; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal., Botelho MF; Institute of Biophysics and Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Centre of Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical and Academic Centre of Coimbra (CACC), Coimbra, Portugal., Pinho E Melo TMVD; Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences, University of Coimbra, Coimbra, Portugal.

Publikováno v: Frontiers in chemistry [Front Chem] 2022 Apr 27; Vol. 10, pp. 873245. Date of Electronic Publication: 2022 Apr 27 (Print Publication: 2022).