Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

Autor: Leonard I. Zon, Roby Joehanes, Eirini Trompouki, Stephen J. Chanock, Alireza Ghamari, Min-Lee Yang, Song Yang, Seraj N. Grimes, Sierra Tseng, Michael Superdock, Daniel E. Bauer, Divya S. Vinjamur, Victoria Chan, Karen Hoi, Richard A. Young, Sonja Boatman, Teresa V. Bowman, Avik Choudhuri, Brian J. Abraham, John L. Rinn, Santhi K. Ganesh, Alan B. Cantor, Kian Hong Kock, Audrey Sporrij, Barbara Hummel, William Mallard, Paul S. Albert, Asher Lichtig, Yi Zhou, Satish K. Nandakumar, Shinichiro Takahashi, Martha L. Bulyk, Leandro M. Colli

Publikováno v: Nature Genetics
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nat Genet

Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms governing phenotypic variation are less

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55bc07dd03b947724044bec1c014c8e
https://doi.org/10.1038/s41588-020-00738-2