Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Serah Kimani"'
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 656-679 (2022)
Breast cancer is the most common malignancy in women worldwide and it remains a global health burden, in part, due to poor response and tolerance to current therapeutics. Drug repurposing, which seeks to identify new indications for existing and inve
Externí odkaz:
https://doaj.org/article/82c29bf656da48c486641b08fdd18a71
Autor:
Bianca Del B. Sahm, Jade Peres, Paula Rezende-Teixeira, Evelyne A. Santos, Paola C. Branco, Anelize Bauermeister, Serah Kimani, Eduarda A. Moreira, Renata Bisi-Alves, Claire Bellis, Mihlali Mlaza, Paula C. Jimenez, Norberto P. Lopes, Glaucia M. Machado-Santelli, Sharon Prince, Leticia V. Costa-Lotufo
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The TBX2 transcription factor plays critical roles during embryonic development and it is overexpressed in several cancers, where it contributes to key oncogenic processes including the promotion of proliferation and bypass of senescence. Importantly
Externí odkaz:
https://doaj.org/article/73482a0c96654764b516582950463422
Autor:
Jenna S. Bleloch, Reyna D. Ballim, Serah Kimani, Jeannette Parkes, Eugenio Panieri, Tarryn Willmer, Sharon Prince
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 9 (2017)
Sarcomas are a heterogeneous group of neoplasms of mesenchymal origin. Approximately 80% arise from soft tissue and 20% originate from bone. To date more than 100 sarcoma subtypes have been identified and they vary in molecular characteristics, patho
Externí odkaz:
https://doaj.org/article/f2c92b138bd84104919e684be05a2720
Autor:
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi
Publikováno v:
Journal of Medicinal Chemistry. 66:5041-5060
Autor:
Serah Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
Cbl-b is a RING-type E3 ubiquitin ligase that is expressed in several immune cell lineages, where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified as an attractive target for cancer immunotherapy due to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2db4dbbe02fc24621e78187a7f8d2166
https://doi.org/10.1101/2023.05.05.539612
https://doi.org/10.1101/2023.05.05.539612
Autor:
Sharon Prince, A. van Niekerk, Saeb Aliwaini, Angelique Blanckenberg, Serah Kimani, Selwyn F. Mapolie, A. Neumann-Mufweba
Publikováno v:
Journal of Organometallic Chemistry. 851:68-78
A series of novel mononuclear 1,3,5-triaza-7-phosphaadamantane (PTA)-based palladacycles were prepared by cleaving μ-Cl binuclear orthopalladated dimers of substituted benzylidene-2,6-diisopropylphenylamines. All complexes were fully characterized u
Autor:
Sharon Prince, Jeannette Parkes, Jenna Bleloch, Serah Kimani, Eugenio Panieri, Reyna Deeya Ballim, Tarryn Willmer
Publikováno v:
Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology, Vol 9 (2017)
Therapeutic Advances in Medical Oncology, Vol 9 (2017)
Sarcomas are a heterogeneous group of neoplasms of mesenchymal origin. Approximately 80% arise from soft tissue and 20% originate from bone. To date more than 100 sarcoma subtypes have been identified and they vary in molecular characteristics, patho
Autor:
Sharon Prince, Serah Kimani, Ikponmwosa Irene, Selwyn F. Mapolie, Adrienne L. Edkins, Suparna Chakraborty, André du Toit, K.N. ArulJothi, Letícia V. Costa-Lotufo, Angelique Blanckenberg, Annick van Niekerk, Ben Loos, Jo de la Mare
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
In women globally, breast cancer is responsible for most cancer-related deaths and thus, new effective therapeutic strategies are required to treat this malignancy. Platinum-based compounds like cisplatin are widely used to treat breast cancer, howev
Autor:
Jenna Bleloch, Angelique Blanckenberg, André du Toit, Serah Kimani, Minkyu Lee, Sharon Prince, Selwyn F. Mapolie, Liezl Gibhard, Lubbe Wiesner, Reyna Deeya Ballim, Ben Loos
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 5, Iss 1, Pp 1-16 (2019)
Cell Death Discovery, Vol 5, Iss 1, Pp 1-16 (2019)
Rhabdomyosarcoma (RMS) forms in skeletal muscle and is the most common soft tissue sarcoma in children and adolescents. Current treatment is associated with debilitating side effects and treatment outcomes for patients with metastatic disease are dis
Autor:
Brandon Weber, Roger Hunter, Serah Kimani, B. Trevor Sewell, Gerhard Venter, James C. Gumbart, Arvind Varsani, Don A. Cowan
Publikováno v:
Journal of Biological Chemistry. 288:28514-28523
All known nitrilase superfamily amidase and carbamoylase structures have an additional glutamate that is hydrogen bonded to the catalytic lysine in addition to the Glu, Lys, Cys "catalytic triad." In the amidase from Geobacillus pallidus, mutating th