Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

Autor: Bhavatharini Kasinathan, Serafin U Colmenares III, Hannah McConnell, Janet M Young, Gary H Karpen, Harmit S Malik

Publikováno v: eLife, Vol 9 (2020)

Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential fun

Externí odkaz: https://doaj.org/article/ff87ca4533974434b7eb2d974ade17fe

Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

Autor: Gary H. Karpen, Harmit S. Malik, Hannah McConnell, Bhavatharini Kasinathan, Janet M. Young, Serafin U. Colmenares

Publikováno v: eLife
eLife, Vol 9 (2020)

Contrary to prevailing dogma, evolutionarily young and dynamic genes can encode essential functions. Here, we investigate genetic innovation inZAD-ZNFgenes, which encode the most abundant class of insect transcription factors. We find that evolutiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c37f75fe1b10699529b9fc0f0fade14
https://doi.org/10.7554/elife.63368

Rapid Evolution of Gained Essential Developmental Functions of a Young Gene via Interactions with Other Essential Genes

Autor: Serafin U Colmenares, Gavin R. Rice, Manyuan Long, Yuh Chwen G. Lee, Dong-Yuan Chen, Iuri M. Ventura

Publikováno v: Mol Biol Evol

New genes originated relatively recently and are only present in a subset of species in a phylogeny. Accumulated evidence suggests that new genes, like old genes that are conserved across species, can also take on important functions and be essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcd668b4f943676712385cd99815173
https://europepmc.org/articles/PMC6759199/

Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity

Autor: Sylvain V. Costes, Serafin U Colmenares, Cameron Kennedy, Gary H. Karpen, Joel M Swenson, Sasha A. Langley

Publikováno v: Developmental cell, vol 42, iss 2
Colmenares, SU; Swenson, JM; Langley, SA; Kennedy, C; Costes, SV; & Karpen, GH. (2017). Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity. Developmental Cell, 42(2), 156-169.e5. doi: 10.1016/j.devcel.2017.06.014. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/06q8n6xh

© 2017 Elsevier Inc. Eukaryotic genomes are broadly divided between gene-rich euchromatin and the highly repetitive heterochromatin domain, which is enriched for proteins critical for genome stability and transcriptional silencing. This study shows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7debfc59f64d014c52597970d8092cfb
https://europepmc.org/articles/PMC5572651/

The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

Autor: Gary H. Karpen, Serafin U Colmenares, Amy R. Strom, Joel M Swenson, Sylvain V. Costes

Publikováno v: Swenson, JM; Colmenares, SU; Strom, AR; Costes, SV; & Karpen, GH. (2016). The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic. ELIFE, 5. doi: 10.7554/eLife.16096. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/1h47w462
eLife, Vol 5 (2016)
eLife
eLife, vol 5, iss AUGUST
Swenson, JM; Colmenares, SU; Strom, AR; Costes, SV; & Karpen, GH. (2016). The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic. eLife, 5(AUGUST). doi: 10.7554/eLife.16096.001. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/1dh673w3

Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions. To elucidate heterochromatin organization and regulation, we purified Drosophila melanogaster HP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4094404d7cce3956d3bcb03b61b2954b
http://www.escholarship.org/uc/item/1h47w462