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Publikováno v:
Mauthe, M, Kampinga, H H, Hipp, M S & Reggiori, F 2023, ' Digest it all : the lysosomal turnover of cytoplasmic aggregates ', Trends in Biochemical Sciences, vol. 48, no. 3, pp. 216-228 . https://doi.org/10.1016/j.tibs.2022.09.012
Aggrephagy describes the selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. In this process, protein aggregates and conglomerates are polyubiquitinated and then sequestered by autophagosomes. Soluble sele