Zobrazeno 1 - 10
of 842
pro vyhledávání: '"Sequence motifs"'
Autor:
Ishani Morbia, Praveen Kumar, Aditi Lakshmi Satish, Akanksha Mudgal, Subhamoy Datta, Umashankar Singh
Publikováno v:
BMC Genomic Data, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract CGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation. It has remained unclear how CGGBP1 integrates multiple
Externí odkaz:
https://doaj.org/article/d800aed12eb943a4bcc6336fc8857cc7
Akademický článek
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Publikováno v:
Mathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 6410-6429 (2021)
Cyclins and related cyclin-dependent kinases play vital roles in regulating the progression in the cell cycle. Understanding the intrinsic mechanisms of cyclins promises knowledge about cell uncontrolled proliferation and prevention of cancer cells.
Externí odkaz:
https://doaj.org/article/9dadfab7b444406a9311a61dbffdb647
Autor:
Georg Back, Dirk Walther
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Intron mediated enhancement (IME) is the potential of introns to enhance the expression of its respective gene. This essential function of introns has been observed in a wide range of species, including fungi, plants, and animals.
Externí odkaz:
https://doaj.org/article/32c709662a794eada20b6b315b8a3291
Autor:
Atsushi Yoshimori, Jürgen Bajorath
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 833 (2023)
In drug design, the prediction of new active compounds from protein sequence data has only been attempted in a few studies thus far. This prediction task is principally challenging because global protein sequence similarity has strong evolutional and
Externí odkaz:
https://doaj.org/article/aa2502292dd54a878a334fbc79eaf0a8
Akademický článek
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Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues
Autor:
Basak Eraslan, Dongxue Wang, Mirjana Gusic, Holger Prokisch, Björn M Hallström, Mathias Uhlén, Anna Asplund, Frederik Pontén, Thomas Wieland, Thomas Hopf, Hannes Hahne, Bernhard Kuster, Julien Gagneur
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 2, Pp 1-25 (2019)
Abstract Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a quantification of their effects are still lacking. Here, we quantified PTR ratios fo
Externí odkaz:
https://doaj.org/article/e19bbe0271ae4aadb03af672401fd357
Autor:
Konstantin Krismer, Molly A. Bird, Shohreh Varmeh, Erika D. Handly, Anna Gattinger, Thomas Bernwinkler, Daniel A. Anderson, Andreas Heinzel, Brian A. Joughin, Yi Wen Kong, Ian G. Cannell, Michael B. Yaffe
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108064- (2020)
Summary: RNA-binding proteins (RBPs) play critical roles in regulating gene expression by modulating splicing, RNA stability, and protein translation. Stimulus-induced alterations in RBP function contribute to global changes in gene expression, but i
Externí odkaz:
https://doaj.org/article/b2fb1fde168d47caad95d9cb6afb1a18
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background RNA regulation is significantly dependent on its binding protein partner, known as the RNA-binding proteins (RBPs). Unfortunately, the binding preferences for most RBPs are still not well characterized. Interdependencies between s
Externí odkaz:
https://doaj.org/article/e7d250eb643043b7bc71df0311a543ae
Publikováno v:
EURASIP Journal on Advances in Signal Processing, Vol 2017, Iss 1, Pp 1-10 (2017)
Abstract Background Diseases like cancer can manifest themselves through changes in protein abundance, and microRNAs (miRNAs) play a key role in the modulation of protein quantity. MicroRNAs are used throughout all kingdoms and have been shown to be
Externí odkaz:
https://doaj.org/article/0a87c222dcf143208dec07fc908c0c69