Cross-ancestry investigation of venousc genomic predictors

Autor: Thibord, F., Klarin, D., Brody, J.A., Chen, M.H., Levin, M.G., Chasman, D.I., Goode, E.L., Hveem, K., Teder-Laving, M., Martinez-Perez, A., Aissi, D., Daian-Bacq, D., Ito, K., Natarajan, P., Lutsey, P.L., Nadkarni, G.N., Vries, P.S. de, Cuellar-Partida, G., Wolford, B.N., Pattee, J.W., Kooperberg, C., Braekkan, S.K., Li-Gao, R.F., Saut, N., Sept, C., Germain, M., Judy, R.L., Wiggins, K.L., Ko, D., O'Donnell, C.J., Taylor, K.D., Giulianini, F., Andrade, M. de, Nost, T.H., Boland, A., Empana, J.P., Koyama, S., Gilliland, T., R. do, Huffman, J.E., Wang, X., Zhou, W., Soria, J.M., Souto, J.C., Pankratz, N., Haessler, J., Hindberg, K., Rosendaal, F.R., Turman, C., Olaso, R., Kember, R.L., Bartz, T.M., Lynch, J.A., Heckbert, S.R., Armasu, S.M., Brumpton, B., Smadja, D.M., Jouven, X., Komuro, I., Clapham, K.R., Loos, R.J.F., Willer, C.J., Sabater-Lleal, M., Pankow, J.S., Reiner, A.P., Morelli, V.M., Ridker, P.M., Vlieg, A.V., Deleuze, J.F., Kraft, P., Rader, D.J., Lee, K.M., Psaty, B.M., Skogholt, A.H., Emmerich, J., Suchon, P., Rich, S.S., Vy, H.T., Tang, W.H., Jackson, R.D., Hansen, J.B., Morange, P.E., Kabrhel, C., Tregouet, D.A., Damrauer, S.M., Johnson, A.D., Smith, N.L.

Publikováno v: Circulation, 146(16), 1225-1242. LIPPINCOTT WILLIAMS & WILKINS

Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a187ab84f114f2dbc120b166a04e6fd3
http://hdl.handle.net/1887/3572038

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Multi-ancestry polygenic risk scores for venous thromboembolism.

Autor: Jee YH; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, USA., Thibord F; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, MD, USA.; The Framingham Heart Study, 73 Mt. Wayte Ave, Suite #2, Framingham, MA, 01702 USA., Dominguez A; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Sept C; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Boulier K; Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA., Venkateswaran V; Department of Oral Biology, University of California Los Angeles School of Dentistry, Los Angeles, CA, USA., Ding Y; Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA., Cherlin T; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Verma SS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Faro VL; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bartz TM; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195., Boland A; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.; Laboratory of Excellence in Medical Genomics, GENMED, Evry, France., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195., Deleuze JF; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.; Laboratory of Excellence in Medical Genomics, GENMED, Evry, France.; Centre d'Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France., Emmerich J; Department of Vascular Medicine, Paris Saint-Joseph Hospital Group, University of Paris, Paris, France.; UMR1153, INSERM CRESS, Paris, France., Germain M; University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France., Johnson AD; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, MD, USA.; The Framingham Heart Study, 73 Mt. Wayte Ave, Suite #2, Framingham, MA, 01702 USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinbson Cancer Center, Seattle WA 98109., Morange PE; Aix-Marseille University, INSERM, INRAE, Centre de Recherche en CardioVasculaire et Nutrition, Laboratory of Haematology, CRB Assistance Publique - Hôpitaux de Marseille, HemoVasc, Marseille, France., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.; Department of Epidemiology, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.; Department of Health Systems and Population Health, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195., Reiner AP; Department of Epidemiology, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.; Division of Public Health Sciences, Fred Hutchinbson Cancer Center, Seattle WA 98109., Smadja DM; Innovative Therapies in Hemostasis, Université de Paris, INSERM, F-75006 Paris, France.; Hematology Department and Biosurgical Research Lab (Carpentier Foundation), Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP-CUP), F-75015 Paris, France., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195., Suchon P; Aix-Marseille University, INSERM, INRAE, Centre de Recherche en CardioVasculaire et Nutrition, Laboratory of Haematology, CRB Assistance Publique - Hôpitaux de Marseille, HemoVasc, Marseille, France., Tang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, 55454, USA., Trégouët DA; University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Pasaniuc B; Department of Oral Biology, University of California Los Angeles School of Dentistry, Los Angeles, CA, USA., Damrauer SM; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Surgery, Department of Genetics, and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA.; Department of Surgery, Corporal Michael Crescenz VA Medical Center, Philadelphia PA., Sanna S; University of Groningen, UMCG, Department of Genetics, Groningen, the Netherlands.; Institute for Genetics and Biomedical Research, National Research Council, Monserrato, Italy., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Kabrhel C; Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Smith NL; Department of Health Systems and Population Health, University of Washington, 4333 Brooklyn Ave, Seattle, WA 98195.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle WA 98101, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle WA 98108, USA., Kraft P; Transdivisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jan 10. Date of Electronic Publication: 2024 Jan 10.