Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Seppo Auriola"'
Autor:
Burak Ozgür, Elena Puris, Andreas Brachner, Antje Appelt-Menzel, Sabrina Oerter, Viktor Balzer, Mikkel Roland Holst, Rasmus Folmann Christiansen, Kathrine Hyldig, Stephen T. Buckley, Mie Kristensen, Seppo Auriola, Allan Jensen, Gert Fricker, Morten Schallburg Nielsen, Winfried Neuhaus, Birger Brodin
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Blood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been regarded as robust models with appropriate properties to examine the functional transport of sm
Externí odkaz:
https://doaj.org/article/a725aae18819471b8862ddc5715b995e
Autor:
Elena Puris, Liudmila Saveleva, Seppo Auriola, Mikko Gynther, Katja M. Kanninen, Gert Fricker
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Membrane transporters playing an important role in the passage of drugs, metabolites and nutrients across the membranes of the brain cells have been shown to be involved in pathogenesis of Alzheimer’s disease (AD). However, little is known about se
Externí odkaz:
https://doaj.org/article/6b1f10f12cd449b08eba11fdd71da552
Autor:
Iman Zarei, Ville M. Koistinen, Marietta Kokla, Anton Klåvus, Ambrin Farizah Babu, Marko Lehtonen, Seppo Auriola, Kati Hanhineva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract The essential role of gut microbiota in health and disease is well recognized, but the biochemical details that underlie the beneficial impact remain largely undefined. To maintain its stability, microbiota participates in an interactive hos
Externí odkaz:
https://doaj.org/article/af2fb9f52e2e482dba0e940ac191693f
Autor:
Agathe Hugele, Susanne Löffler, Belén Hernández Molina, Melina Guillon, Ahmed B. Montaser, Seppo Auriola, Kristiina M. Huttunen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utiliz
Externí odkaz:
https://doaj.org/article/cce3d5a18df2438abe6395b679fabb6b
Autor:
Elena Puris, Seppo Auriola, Sabrina Petralla, Robin Hartman, Mikko Gynther, Elizabeth C.M. de Lange, Gert Fricker
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105741- (2022)
There is growing evidence that membrane transporters expressed at the blood-brain barrier (BBB) and brain parenchymal cells play an important role in Alzheimer's disease (AD) development and progression. However, quantitative information about change
Externí odkaz:
https://doaj.org/article/195f09b68eac45ce9396e5e3fb99bd6a
Autor:
Elena Puris, Aaro Jalkanen, Seppo Auriola, Sanna Loppi, Paula Korhonen, Katja M. Kanninen, Tarja Malm, Jari Koistinaho, Mikko Gynther
Publikováno v:
Brain Disorders, Vol 6, Iss , Pp 100035- (2022)
Changes in brain prolyl oligopeptidase (PREP) expression and activity have been associated with neuroinflammation and Alzheimer`s disease (AD). The role of PREP in AD, which onset can be contributed by peripheral infection-induced inflammation, is un
Externí odkaz:
https://doaj.org/article/f0d2ca8985b14c27a4d8893c51b03431
Autor:
Annie M. Constable, Dimitris Vlachopoulos, Alan R. Barker, Sarah A. Moore, Sonja Soininen, Eero A. Haapala, Juuso Väistö, Jarmo Jääskeläinen, Raimo Voutilainen, Seppo Auriola, Merja R. Häkkinen, Tomi Laitinen, Timo A. Lakka
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionWe aimed to investigate whether the relationship between fat mass and bone mineral content (BMC) is mediated by insulin, leptin, adiponectin, dehydroepiandrosterone sulphate, testosterone and estradiol in children aged 9-11 years.Material
Externí odkaz:
https://doaj.org/article/a125dc2e8a0542caa271ba1349b0abdc
Autor:
Ville M. Koistinen, Marjo Tuomainen, Pekka Lehtinen, Petri Peltola, Seppo Auriola, Karin Jonsson, Kati Hanhineva
Publikováno v:
npj Science of Food, Vol 4, Iss 1, Pp 1-9 (2020)
Abstract Whole grain consumption reduces the risk of several chronic diseases. A major contributor to the effect is the synergistic and additive effect of phytochemicals. Malting is an important technological method to process whole grains; the main
Externí odkaz:
https://doaj.org/article/7d8014ec796743d480e2bd9f3acff728
Autor:
Mikko Gynther, Mariana Leal Estrada, Sanna Loppi, Paula Korhonen, Katja M. Kanninen, Tarja Malm, Jari Koistinaho, Seppo Auriola, Gert Fricker, Elena Puris
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2438 (2022)
Cytosolic phospholipase A2 (cPLA2) is an enzyme regulating membrane phospholipid homeostasis and the release of arachidonic acid utilized in inflammatory responses. It represents an attractive target for the treatment of Alzheimer’s disease (AD). P
Externí odkaz:
https://doaj.org/article/a8eeb5a399044ce58688106e82650623
Autor:
Paavo Raittinen, Kati Niemistö, Erika Pennanen, Heimo Syvälä, Seppo Auriola, Jarno Riikonen, Terho Lehtimäki, Pauliina Ilmonen, Teemu Murtola
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Prostate cancer patients using cholesterol-lowering statins have 30% lower risk of prostate cancer death compared to non-users. The effect is attributed to the inhibition of the mevalonate pathway in prostate cancer cells. Moreover, statin u
Externí odkaz:
https://doaj.org/article/25b99540e9c54e4abc8a9297592afb94