Zobrazeno 1 - 10
of 952
pro vyhledávání: '"Seppo Ylä-Herttuala"'
Autor:
Farhana Jahan, Leena Penna, Annu Luostarinen, Laurens Veltman, Heidi Hongisto, Kaarina Lähteenmäki, Sabine Müller, Seppo Ylä-Herttuala, Matti Korhonen, Kim Vettenranta, Anita Laitinen, Urpu Salmenniemi, Erja Kerkelä
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Natural killer (NK) cells are a promising allogeneic immunotherapy option due to their natural ability to kill tumor cells, and due to their apparent safety. This study describes the development of a GMP-compliant manufacturing protocol for
Externí odkaz:
https://doaj.org/article/b4949fb2a86c4f2ea2ea182932cf3e7c
Autor:
Jens Kastrup, Anthony Mathur, Francisco Fernández-Avilés, Matthew Kelham, Juhani Knuuti, Daniel A Jones, Seppo Ylä-Herttuala, Antti Saraste, Ricardo Sanz-Ruiz, Aleksi J Leikas, Juha E K Hartikainen, Mariann Gyöngyösi, Wojtek Wojakowski, Adrian Gwizdała, Riho Luite, Marko Nikkinen, Abbas A Qayyum, Mandana Haack-Sørensen, Kevin Hamzaraj, Andreas Spannbauer, Maria E Fernández-Santos, Marek Jędrzejek, Agnieszka Skoczyńska, Niklas Vartiainen
Publikováno v:
Open Heart, Vol 11, Iss 2 (2024)
Background Despite tremendous therapeutic advancements, a significant proportion of coronary artery disease patients suffer from refractory angina pectoris, that is, quality-of-life-compromising angina that is non-manageable with established pharmaco
Externí odkaz:
https://doaj.org/article/568f4e4255744c448364960cbaf7874c
Autor:
Jaakko Lampela, Juho Pajula, Niko Järveläinen, Satu Siimes, Nihay Laham-Karam, Antti Kivelä, Isidore Mushimiyimana, Jussi Nurro, Juha Hartikainen, Seppo Ylä-Herttuala
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Heart failure (HF) is a major burden worldwide, and new therapies are urgently needed. Gene therapy is a promising new approach to treat myocardial diseases. However, current cardiac gene delivery methods for producing global myocardial effe
Externí odkaz:
https://doaj.org/article/e1082cb239494cd496817d852e1222e7
Autor:
Roosa Kaarijärvi, Heidi Kaljunen, Lucia Nappi, Ladan Fazli, Sonia H. Y. Kung, Jaana M. Hartikainen, Ville Paakinaho, Janne Capra, Kirsi Rilla, Marjo Malinen, Petri I. Mäkinen, Seppo Ylä-Herttuala, Amina Zoubeidi, Yuzhuo Wang, Martin E. Gleave, Mikko Hiltunen, Kirsi Ketola
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study unveils that AR suppresses the neuronal development protein dihyd
Externí odkaz:
https://doaj.org/article/46ae70a2bbdb4b58945c409e3ad0a352
Autor:
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen, Davide M. Trevisan, Ana Hernandez de Sande, Mireia Gomez-Budia, Raisa Giniatullina, Irene F. Ugidos, Hiramani Dhungana, Cristiana Pistono, Nea Korvenlaita, Nelli-Noora Välimäki, Salla M. Kangas, Anniina E. Hiltunen, Emma Gribchenko, Minna U. Kaikkonen-Määttä, Jari Koistinaho, Seppo Ylä-Herttuala, Reetta Hinttala, Morten T. Venø, Junyi Su, Markus Stoffel, Anne Schaefer, Nikolaus Rajewsky, Jørgen Kjems, Mary P. LaPierre, Monika Piwecka, Jukka Jolkkonen, Rashid Giniatullin, Thomas B. Hansen, Tarja Malm
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113862- (2024)
Summary: Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7, and the long ncRNA Cyrano. We de
Externí odkaz:
https://doaj.org/article/3f5181ebf602423b89fa5aca16a2796d
Autor:
Sanna Kettunen, Tuisku Suoranta, Sadegh Beikverdi, Minja Heikkilä, Anna Slita, Iida Räty, Elias Ylä-Herttuala, Katariina Öörni, Anna-Kaisa Ruotsalainen, Seppo Ylä-Herttuala
Publikováno v:
Cells, Vol 13, Iss 11, p 983 (2024)
The 9p21.3 genomic locus is a hot spot for disease-associated single-nucleotide polymorphisms (SNPs), and its strongest associations are with coronary artery disease (CAD). The disease-associated SNPs are located within the sequence of a long noncodi
Externí odkaz:
https://doaj.org/article/da168086675543719c8c3c3303973a12
Autor:
Elias Ylä-Herttuala, PhD, Muhammad Arsalan Khan, Svetlana Laidinen, Hanne Laakso, PhD, Tommi Heikura, Seppo Ylä-Herttuala, MD, PhD, Timo Liimatainen, PhD
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss , Pp 100735- (2024)
Externí odkaz:
https://doaj.org/article/94cbca68a9d7404095ea32eda3bcd2ec
Autor:
Elias Ylä-Herttuala, Taina Vuorio, Sanna Kettunen, Svetlana Laidinen, Seppo Ylä-Herttuala, Timo Liimatainen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The role of cardiac lymphatics in the pathogenesis of myocardial infarction (MI) is unclear. Lymphatic system regulates cardiac physiological processes such as edema and tissue fluid balance, which affect MI pathogenesis. Recently, MI and fi
Externí odkaz:
https://doaj.org/article/287bce11a6584195874c2bbec6a455a7
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Introduction: The eye is an excellent target for gene therapy because of its anatomical features. Gene therapy to treat ocular disorders relies on efficient gene delivery and transgene expression in the target cells. The aim of this study was to comp
Externí odkaz:
https://doaj.org/article/1dc344c761d7463193491f7f70b3ca99
Autor:
Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, Heidi H Pulkkinen, Sara Keränen, Miika Kiema, Jade J Liikkanen, Nihay Laham-Karam, Svetlana Laidinen, Mustafa Beter, Einari Aavik, Kimmo Lappalainen, Jouko Lohi, Johanna Aronniemi, Tiit Örd, Minna U Kaikkonen, Päivi Salminen, Erkki Tukiainen, Seppo Ylä-Herttuala, Johanna P Laakkonen
Publikováno v:
eLife, Vol 12 (2023)
Background: Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility disturbances to
Externí odkaz:
https://doaj.org/article/befc893b2b91488f9cccd0243f8b744c