Overcoming the barriers to identifying and managing treatment-resistant schizophrenia and to improving access to clozapine: A narrative review and recommendation for clinical practice.

Autor: Agid O; Centre for Addiction and Mental Health, University of Toronto, Canada., Crespo-Facorro B; Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocío-IBiS-CSIC, Sevilla, Spain, Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Sevilla, Spain., de Bartolomeis A; University of Naples Federico II, Department of Neuroscience, Reproductive Science, and Odontostomatology. Laboratory of Molecular and Translational Psychiatry. Unit of Treatment Resistant Psychosis, Naples, Italy; Staff Unesco Chair at University of Naples Federico II, Italy., Fagiolini A; University of Siena, Siena, Italy., Howes OD; IoPPN, King's College London, De Crespigny Park, London, United Kingdom; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London, United Kingdom., Seppälä N; Wellbeing Services in Satakunta, Department of Psychiatry, Pori, Finland and Medical Consultant, Viatris, Finland., Correll CU; The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, New York, United States; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, New York, United States; Charité - Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Augustenburger Platz 1, Berlin 13353, Germany; German Center for Mental Health (DZPG), Partner Site Berlin, Berlin, Germany. Electronic address: christoph.correll@charite.de.

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2024 Jul; Vol. 84, pp. 35-47. Date of Electronic Publication: 2024 Apr 23.

Association study of the HTR2C, leptin and adiponectin genes and serum marker analyses in clozapine treated long-term patients with schizophrenia

Autor: Klemettilä, J.-P., Kampman, O., Seppälä, N., Viikki, M., Hämäläinen, M., Moilanen, E., Mononen, N., Lehtimäki, T., Leinonen, E.

Publikováno v: In European Psychiatry February 2015 30(2):296-302

A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia.

Autor: Correll CU; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.; Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA., Agid O; Department of Psychiatry, University of Toronto, Toronto, Canada., Crespo-Facorro B; CIBERSAM, Hospital Universitario Virgen del Rocío, IBiS, Universidad de Sevilla, Sevilla, Spain., de Bartolomeis A; Section on Clinical Psychiatry and Psychology, Laboratory of Molecular and Translational Psychiatry and Unit of Treatment Resistant Psychosis, University of Naples Federico II, Naples, Italy., Fagiolini A; Department of Molecular Medicine, University of Siena, Siena, Italy., Seppälä N; Department of Psychiatry Satasairaala, Harjavalta, Finland., Howes OD; Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK. oliver.howes@kcl.ac.uk.

Publikováno v: CNS drugs [CNS Drugs] 2022 Jul; Vol. 36 (7), pp. 659-679. Date of Electronic Publication: 2022 Jun 27.

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

Autor: de Leon J; Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.; Department of Psychiatry, University of Kentucky, Lexington, KY, USA.; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain.; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain., Schoretsanitis G; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland.; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA., Smith RL; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway., Solismaa A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Psychiatry, Tampere University Hospital, Tampere, Finland., Seppälä N; Department of Psychiatry, Satasairaala, Finland., Kopeček M; National Institute of Mental Health, Klecany, Czech Republic.; Department of Psychiatry, Charles University, Third Faculty of Medicine, Prague, Czech Republic., Švancer P; National Institute of Mental Health, Klecany, Czech Republic.; Department of Psychiatry, Charles University, Third Faculty of Medicine, Prague, Czech Republic., Olmos I; Clinical Pharmacology Unit and Pharmacy Department, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay., Ricciardi C; Clinical Pharmacology Unit and Outpatient Clinic, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay., Iglesias-Garcia C; Universidad de Oviedo. CIBERSAM. INEUROPA. ISPA-FIMBA, Oviedo, Spain.; Hospital Valle del Nalón, Langreo, Spain., Iglesias-Alonso A; Hospital Universitario Central de Asturias, Oviedo, Spain., Spina E; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Ruan CJ; Laboratory of Clinical Psychopharmacology, Beijing Anding Hospital, Capital Medical University, Beijing, China.; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China., Wang CY; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.; Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China., Wang G; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China., Tang YL; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Substance Abuse Treatment Program, Atlanta VA Medical Center, Decatur, Georgia, USA., Lin SK; Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan., Lane HY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Psychiatry and Brain Disease Research Center, China Medical University Hospital, Taichung, Taiwan.; Department of Psychology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan., Kim YS; Department of Neuropsychiatry, Nowon Eulji Medical Center, Eulji University, School of Medicine, Seoul, Korea., Kim SH; Department of Psychiatry, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Rajkumar AP; Department of Psychiatry, Christian Medical College, Vellore, India.; Institute of Mental Health, Jubilee Campus, University of Nottingham, Triumph Road, Nottingham, United Kingdom., González-Esquivel DF; Instituto Nacional de Neurología y Neurocirugía, México City, México., Jung-Cook H; Instituto Nacional de Neurología y Neurocirugía, México City, México.; Facultad de Química, Universidad Nacional Autónoma de México (UNAM), México City, México., Baptista T; Department of Physiology, Los Andes University Medical School, Mérida, Venezuela., Rohde C; Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nielsen J; Mental Health Centre Glostrup, Copenhagen University Hospital, Copenhagen, Denmark., Verdoux H; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France., Quiles C; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France., Sanz EJ; Department of Physical Medicine and Pharmacology, School of Medicine, Universidad de La Laguna, Canary Islands, Spain.; Hospital Universitario de Canarias, Tenerife, Spain., De Las Cuevas C; Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, and Instituto Universitario de Neurociencia (IUNE), University of La Laguna, Canary Islands, Spain., Cohen D; Dutch Clozapine Collaboration Group, Castricum, The Netherlands.; FACT-team in Heerhugowaard, Department of Severe Mental Illness, Mental Health Services North-Holland North, The Netherlands., Schulte PFJ; Dutch Clozapine Collaboration Group, Castricum, The Netherlands.; Mental Health Team Alkmaar, Mental Health Services Noord-Holland-Noord, Alkmaar, The Netherlands., Ertuğrul A; Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey., Anıl Yağcıoğlu AE; Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey., Chopra N; Addictions Division, Centre for Addiction and Mental Health, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., McCollum B; Eastern State Hospital, Lexington, Kentucky, USA., Shelton C; Department of Psychiatry, University of Kentucky, Lexington, KY, USA.; Eastern State Hospital, Lexington, Kentucky, USA., Cotes RO; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Kaithi AR; Hazelwood Center, Louisville, Kentucky, USA., Kane JM; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead, New York, USA., Farooq S; School of Medicine, Keele University, Staffordshire, and Midlands Partnership NHS Foundation Trust, Staffordshire, United Kingdom., Ng CH; Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia., Bilbily J; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA., Hiemke C; Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany., López-Jaramillo C; Grupo de Investigación en Psiquiatría GIPSI, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia.; Programa Trastornos del Ánimo, Hospital Universitario San Vicente Fundación, Medellín, Colombia., McGrane I; Department of Pharmacy Practice, University of Montana, Missoula, USA., Lana F; Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Barcelona, Spain.; Department of Psychiatry, Autonomous University of Barcelona, Spain., Eap CB; Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland.; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Switzerland., Arrojo-Romero M; Department of Psychiatry, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain., Rădulescu FŞ; Center for Drug Sciences, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Seifritz E; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland., Every-Palmer S; Te Korowai Whāriki Central Regional Forensic Service, Capital and Coast District Health Board, Wellington, New Zealand.; Department of Psychological Medicine, University of Otago, Wellington, New Zealand., Bousman CA; Departments of Medical Genetics, Psychiatry, Physiology & Pharmacology, and Community Health Sciences University of Calgary, Alberta, Canada., Bebawi E; Faculty of Medicine, University of Montreal, Montreal, Canada.; Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montreal, Canada., Bhattacharya R; East London NHS Foundation Trust, London, United Kingdom.; Honorary Clinical Senior Lecturer, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom., Kelly DL; Department of Psychiatry, School of Medicine, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Otsuka Y; Department of Psychiatry, Asahi General Hospital, Chiba, Japan., Lazary J; National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary., Torres R; Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Yecora A; Secretaría de Salud Mental y Adicciones, Ministerio de Salud de la Provincia de Jujuy, San Salvador de Jujuy, Argentina., Motuca M; Instituto Vilapriño, Center for Studies, Assistance and Research in Neurosciences, Mendoza, Argentina., Chan SKW; Department of Psychiatry, LSK Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR., Zolezzi M; College of Pharmacy, QU Health, Qatar University, Doha, Qatar., Ouanes S; Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar., De Berardis D; NHS, Department of Mental Health, 'G. Mazzini' Hospital, Teramo, Italy., Grover S; Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Procyshyn RM; British Columbia Mental Health and Substance Use Research Institute, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada., Adebayo RA; Federal Neuropsychiatric Hospital Yaba, Lagos, Nigeria., Kirilochev OO; Department of Clinical Pharmacology, Astrakhan State Medical University, Astrakhan, Russian Federation., Soloviev A; Department of Psychiatry and Clinical Psychology, Northern State Medical University, Arkhangelsk, Russia., Fountoulakis KN; 3rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece., Wilkowska A; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland., Cubała WJ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland., Ayub M; Department of Psychiatry, Queens University, Kingston, Canada., Silva A; Psychiatry Department, Centro Hospitalar Universitário de S. João, Porto, Portugal.;  Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Bonelli RM;  Sigmund Freud University, Vienna, Austria., Villagrán-Moreno JM;  Department of Neurosciences, Jerez University Hospital, Andalusian Health Service, University of Cadiz, Jerez, Spain., Crespo-Facorro B;  Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocio-IBIS, Sevilla, Spain.;  Spanish Network for Research in Mental Health (CIBERSAM), Sevilla, Spain., Temmingh H; Department of Psychiatry and Mental Health, University of Cape Town, Valkenberg Hospital, Western Cape, Cape Town, South Africa., Decloedt E; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Pedro MR; Hospital Central de Maputo, Maputo, Mozambique., Takeuchi H; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Tsukahara M; Department of Psychiatry, Okayama Psychiatric Medical Center, Okayama, Japan., Gründer G; Central Institute of Mental Health, Department of Molecular Neuroimaging, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Sagud M; Department of Psychiatry, School of Medicine, University of Zagreb, Zagreb, Croatia.; Department for Psychiatry and Psychological Medicine, University Hospital Center Zagreb, Croatia., Celofiga A; Department of Psychiatry, University Medical Centre Maribor, Maribor, Slovenia., Ignjatovic Ristic D; University of Kragujevac, Faculty of Medical Sciences, Department of Psychiatry, Kragujevac, Serbia., Ortiz BB; Group of Resistant Schizophrenia (GER), Schizophrenia Program (Proesq), Federal University of Sao Paulo, SP, Brazil., Elkis H; Department and Institute of Psychiatry, University of São Paulo Medical School (FMUSP), Sao Paulo, Brazil., Pacheco Palha AJ; Department and Institute of Psychiatry and Mental Health, Oporto Faculty of Medicine, Oporto, Portugal.; Casa de Salidedo Som Jesus (Psychiatric Hospital), Oporto, Portugal., LLerena A; INUBE Biosanitary Research Institute of Extremadura. Extremadura University Hospital and Medical School, Badajoz, Spain.; Spanish Network for Research in Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain., Fernandez-Egea E; Cambridge Psychosis Centre, Cambrigeshire and Peterborough NHS Foundation Trust & Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom., Siskind D; Metro South Addiction and Mental Health Service, Brisbane, Australia.; Queensland Centre for Mental Health Research and School of Clinical Medicine, University of Queensland, Brisbane, Australia., Weizman A; Research Unit, Geha Mental Health Center and Molecular Psychiatry Laboratory, Felsenstein Medical Research Center, Tel Aviv, Israel.; Department of Psychiatry Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Masmoudi R; Psychiatry 'A' Department, Hedi Chaker University Hospital, Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Sfax, Tunisia., Mohd Saffian S; Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Leung JG; Department of Pharmacy, Mayo Clinic, Rochester, MN, USA., Buckley PF; School of Medicine, Virginia Commonwealth University, Richmond, VA, USA., Marder SR; Semel Institute for Neuroscience at UCLA, Los Angeles, CA, USA.; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA., Citrome L; New York Medical College, Department of Psychiatry and Behavioral Sciences, Valhalla, NY, USA., Freudenreich O; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Correll CU; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead, New York, USA.; Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany., Müller DJ; Addictions Division, Centre for Addiction and Mental Health, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Pharmacopsychiatry [Pharmacopsychiatry] 2022 Mar; Vol. 55 (2), pp. 73-86. Date of Electronic Publication: 2021 Dec 15.

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