European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

Autor: Seppälä, TT, Latchford, A, Negoi, I, Soares, AS, Jimenez-Rodriguez, R, Sánchez-Guillén, L, Evans, DG, Ryan, N, Crosbie, EJ, Dominguez-Valentin, M, Burn, J, Kloor, M, von Knebel Doeberitz, M, van Duijnhoven, JB, Quirke, P, Sampson, JR, Møller, P, Möslein, G, the European Hereditary Tumour Group (EHTG) and European Society

Background Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have recently increased understanding of the effectiveness of colonoscopic surveillance and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e2e7e0e5568df24eaafacb1b72fd8244

Longitudinal changes of CSF biomarkers in Alzheimer's disease.

Autor: Seppälä TT, Koivisto AM, Hartikainen P, Helisalmi S, Soininen H, Herukka SK, Seppälä, Toni T, Koivisto, Anne M, Hartikainen, Päivi, Helisalmi, Seppo, Soininen, Hilkka, Herukka, Sanna-Kaisa

Publikováno v: Journal of Alzheimer's Disease; 2011, Vol. 23 Issue 1, p583-594, 12p

Detection of a major Lynch Syndrome-causing MLH1 founder variant in a large-scale genotyped cohort.

Autor: Sipilä LJ; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Finnish Cancer Registry, Unioninkatu 22, 00130, Helsinki, Finland., Aavikko M; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Ravantti J; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, FI-00014, Helsinki, Finland., Martin S; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland., Kuopio T; Central Finland Biobank, Wellbeing Services County of Central Finland and University of Jyväskylä, Jyväskylä, Finland., Lahtinen L; Department of Pathology, Wellbeing Services County of Central Finland, Jyväskylä, Finland., FinnGen; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Peltomäki P; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; HUSLAB Laboratory of Genetics, HUS Diagnostic Center, HUS, Helsinki University Hospital, 00029, Helsinki, Finland., Mecklin JP; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; Department of Surgery, Nova Hospital, Jyväskylä, Finland., Aaltonen LA; Department of Medical and Clinical Genetics, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, 00290, Helsinki, Finland., Seppälä TT; Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Biomedicum Helsinki Haartmaninkatu 8), PO Box 63, 00014, Helsinki, Finland. toni.seppala@helsinki.fi.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, 00290, Helsinki, Finland. toni.seppala@helsinki.fi.; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. toni.seppala@helsinki.fi.; Tays Cancer Centre, Tampere University Hospital, Tampere, Finland. toni.seppala@helsinki.fi.; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. toni.seppala@helsinki.fi.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland. toni.seppala@helsinki.fi.

Publikováno v: Familial cancer [Fam Cancer] 2024 Nov; Vol. 23 (4), pp. 647-652. Date of Electronic Publication: 2024 Jun 07.

Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer.

Autor: Kastinen M; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Sirniö P; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Elomaa H; Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä.; Department of Education and Research, Central Finland Health Care District, Jyväskylä., Äijälä VK; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Karjalainen H; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Tapiainen VV; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Pohjanen VM; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Kemppainen J; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Sliashynskaya K; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Ahtiainen M; Department of Pathology, Central Finland Health Care District, Jyväskylä., Rintala J; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Meriläinen S; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Rautio T; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Saarnio J; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Mattila TT; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Lindgren O; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Wirta EV; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere., Helminen O; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Seppälä TT; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere.; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki.; Applied Tumor Genomics, Research Program Unit, University of Helsinki, Helsinki., Böhm J; Department of Pathology, Central Finland Health Care District, Jyväskylä., Mecklin JP; Department of Education and Research, Central Finland Health Care District, Jyväskylä.; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Tuomisto A; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Mäkinen MJ; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu., Väyrynen JP; Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu.

Publikováno v: The American journal of surgical pathology [Am J Surg Pathol] 2024 Oct 01; Vol. 48 (10), pp. 1284-1292. Date of Electronic Publication: 2024 Jul 15.

Patient-derived Organoid Pharmacotyping As A Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma.

Autor: Nicolson NG; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA., Tandurella JA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Cell and Molecular Biology Cancer Biology Program, University of Pennsylvania, Philadelphia, PA, USA., Wu LW; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.; Division of Hematology and Medical Oncology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Patel J; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital., Morris E; Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA., Seppälä TT; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital., Guinn S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Zlomke H; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.; Department of Surgery, Medical University of South Carolina, Charleston, SC., Shubert CR; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA., Lafaro KJ; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA., Burns WR; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA., Cameron JL; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA., He J; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA., Fertig EJ; Division of Quantitative Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Zimmerman JW; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Burkhart RA; Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.; Cancer Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Publikováno v: Annals of surgery [Ann Surg] 2024 Sep 04. Date of Electronic Publication: 2024 Sep 04.