Zobrazeno 1 - 10
of 549
pro vyhledávání: '"Seppälä, I."'
Autor:
Oksala, N.K.J., Seppälä, I., Rahikainen, R., Mäkelä, K.-M., Raitoharju, E., Illig, T., Klopp, N., Kholova, I., Laaksonen, R., Karhunen, P.J., Hytönen, V.P., Lehtimäki, T.
Publikováno v:
In European Journal of Vascular & Endovascular Surgery May 2017 53(5):632-640
Autor:
Ahluwalia, TS, Prins, BP, Abdollahi, M, Armstrong, NJ, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-Shlomo, Y, Bis, JC, Mitchell, BD, de Geus, E, Delgado, GE, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, JP, Lu, C, Marioni, RE, McLachlan, S, Milaneschi, Y, Nolte, IM, Petrelis, AM, Porcu, E, Sabater-Lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, CM, Benjamin, EJ, Casas, JP, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, MF, Grallert, H, Hammarstedt, A, Harris, SE, Homuth, G, Hottenga, J-J, Jalkanen, S, Jamshidi, Y, Jawahar, MC, Jess, T, Kivimaki, M, Kleber, ME, Lahti, J, Liu, Y, Marques-Vidal, P, Mellström, D, Mooijaart, SP, Müller-Nurasyid, M, Penninx, B, Revez, JA, Rossing, P, Räikkönen, K, Sattar, N, Scharnagl, H, Sennblad, B, Silveira, A, Pourcain, BS, Timpson, NJ, Trollor, J, CHARGE Inflammation Working Group, van Dongen, J, Van Heemst, D, Visvikis-Siest, S, Vollenweider, P, Völker, U, Waldenberger, M, Willemsen, G, Zabaneh, D, Morris, RW, Arnett, DK, Baune, BT, Boomsma, DI, Chang, Y-PC, Deary, IJ, Deloukas, P, Eriksson, JG, Evans, DM, Ferreira, MA, Gaunt, T, Gudnason, V, Hamsten, A, Heinrich, J, Hingorani, A, Humphries, SE, Jukema, JW, Koeing, W, Kumari, M, Kutalik, Z, Lawlor, DA, Lehtimäki, T, März, W, Mather, K, Naitza, S, Nauck, M, Ohlsson, C, Price, JF, Raitakari, O, Rice, K, Sachdev, PS, Slagboom, E, Sørensen, TIA, Spector, T, Stacey, D, Stathopoulou, MG, Tanaka, T, Wannamethee, SG, Whincup, P, Rotter, JI, Dehghan, A, Boerwinkle, E, Psaty, BM, Snieder, H, Alizadeh, BZ
Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::043796f2040210709135c769baeddf98
https://openaccess.sgul.ac.uk/id/eprint/112959/9/ddab023.pdf
https://openaccess.sgul.ac.uk/id/eprint/112959/9/ddab023.pdf
Akademický článek
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Autor:
Lamina, C., Kronenberg, F., Mack, S., Coassin, S., Rueedi, R., Yousri, N.A., Seppälä, I., Lp(a)-GWAS-Consortium (Gieger, C.), Schönherr, S., Forer, L., Erhart, G., Marques-Vidal, P., Lp(a)-GWAS-Consortium (Ried, J.S.), Waeber, G., Bergmann, S., Daehnhardt, D., Stoeckl, A., Raitakari, O.T., Kähönen, M., Lp(a)-GWAS-Consortium (Peters, A.), Lp(a)-GWAS-Consortium (Meitinger, T.), Lp(a)-GWAS-Consortium (Strauch, K.), Kedenko, L., Paulweber, B., Lehtimäki, T., Hunt, S.C., Vollenweider, P.
Publikováno v:
JAMA Cardiol. 4, 575-579 (2019)
Importance Genetic and epidemiologic data suggest that lipoprotein(a) (Lp[a]) is one of the strongest genetically determined risk factors for coronary heart disease (CHD). Specific therapies to lower Lp(a) are on the horizon, but the required reducti
Autor:
Timmers, P.R., Mounier, N., Lall, K., Fischer, K., Ning, Z., Feng, X., Bretherick, A.D., Clark, D.W., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Awadalla, P., Battle, A., Bonder, M.J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., van Dongen, J., Esko, T., Favé, M., Franke, L., Frayling, T., Gharib, S.A., Gibson, G., Hemani, G., Jansen, R., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Kutalik, Z., Kähönen, M., Lee, B., Lehtimäki, T., Loeffler, M., Marigorta, U., Metspalu, A., van Meurs, J., Milani, L., Müller-Nurasyid, M., Nauck, M., Nivard, M., Penninx, B., Perola, M., Pervjakova, N., Pierce, B., Powell, J., Prokisch, H., Psaty, B.M., Raitakari, O., Ring, S., Ripatti, S., Rotzschke, O., Ruëger, S., Saha, A., Scholz, M., Schramm, K., Seppälä, I., Stumvoll, M., Sullivan, P., Teumer, A., Thiery, J., Tong, L., Tönjes, A., Verlouw, J., Visscher, P.M., Võsa, U., Völker, U., Yaghootkar, H., Yang, J., Zeng, B., Zhang, F., Shen, X., Wilson, J.F., Joshi, P.K.
Publikováno v:
eLife, vol. 8, pp. e39856
eLife
eLife 8:e39856 (2019)
eLife, 8. eLife Sciences Publications Limited
eLife, Vol 8 (2019)
Timmers, P R, Mounier, N, Lall, K, Fischer, K, Ning, Z, Feng, X, Bretherick, A D, Clark, D W, Shen, X, Esko, T, Kutalik, Z, Wilson, J F, Joshi, P K & eQTLGen Consortium 2019, ' Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances ', eLife, vol. 8 . https://doi.org/10.7554/eLife.39856
eLife
eLife 8:e39856 (2019)
eLife, 8. eLife Sciences Publications Limited
eLife, Vol 8 (2019)
Timmers, P R, Mounier, N, Lall, K, Fischer, K, Ning, Z, Feng, X, Bretherick, A D, Clark, D W, Shen, X, Esko, T, Kutalik, Z, Wilson, J F, Joshi, P K & eQTLGen Consortium 2019, ' Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances ', eLife, vol. 8 . https://doi.org/10.7554/eLife.39856
We use a genome-wide association of 1 million parental lifespans of genotyped subjects and data on mortality risk factors to validate previously unreplicated findings near CDKN2B-AS1, ATXN2/BRAP, FURIN/FES, ZW10, PSORS1C3, and 13q21.31, and identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::48226c49150697a2cd359bc562fc0330
https://serval.unil.ch/notice/serval:BIB_771D2C9E3799
https://serval.unil.ch/notice/serval:BIB_771D2C9E3799
Autor:
Dobewall, H. (Henrik), Savelieva, K. (Kateryna), Seppälä, I. (Ilkka), Knafo-Noam, A. (Ariel), Hakulinen, C. (Christian), Elovainio, M. (Marko), Keltikangas-Järvinen, L. (Liisa), Pulkki-Råback, L. (Laura), Raitakari, O. T. (Olli T.), Lehtimäki, T. (Terho), Hintsanen, M. (Mirka)
Background: Genomic analysis of the child might offer new potential to illuminate human parenting. We examined whether offspring (G2) genome‐wide genotype variation (SNPs) is associated with their mother’s (G1) emotional warmth and intolerance, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::93277c783003fb177c81474bc9eaa329
http://urn.fi/urn:nbn:fi-fe202003259260
http://urn.fi/urn:nbn:fi-fe202003259260
Autor:
Mack, S., Coassin, S., Vaucher, J., Kronenberg, F., Lamina, C., Rueedi, R., Yousri, N.A., Seppälä, I., ApoA-IV-GWAS Constortium (Gieger, C.), Schönherr, S., Forer, L., Erhart, G., Kollerits, B., Marques-Vidal, P., ApoA-IV-GWAS Constortium (Müller-Nurasyid, M.), Waeber, G., Bergmann, S., Dähnhardt, D., Stöckl, A., Kiechl, S., Raitakari, O.T., Kähönen, M., Willeit, J., Kedenko, L., Paulweber, B., ApoA-IV-GWAS Constortium (Peters, A.), ApoA-IV-GWAS Constortium (Meitinger, T.), ApoA-IV-GWAS Constortium (Strauch, K.), Lehtimäki, T., Hunt, S.C., Vollenweider, P.
Publikováno v:
Sci. Rep. 7:8734 (2017)
Scientific Reports
Scientific reports, vol. 7, no. 1, pp. 8734
Scientific Reports
Scientific reports, vol. 7, no. 1, pp. 8734
Apolipoprotein A-IV (apoA-IV) has been observed to be associated with lipids, kidney function, adiposity- and diabetes-related parameters. To assess the causal relationship of apoA-IV with these phenotypes, we conducted bidirectional Mendelian random
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::12e928ef4ac166f41b485ba36d9ef428
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51766
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51766
Autor:
Lamina, C., Friedel, S., Coassin, S., Rueedi, R., Yousri, N.A., Seppälä, I., Gieger, C., Schönherr, S., Forer, L., Erhart, G., Kollerits, B., Marques-Vidal, P., Ried, J., Waeber, G., Bergmann, S., Dähnhardt, D., Stöckl, A., Kiechl, S., Raitakari, O.T., Kähönen, M., Willeit, J., Kedenko, L., Paulweber, B., Peters, A., Meitinger, T., Strauch, K., Study Group, K., Lehtimäki, T., Hunt, S.C., Vollenweider, P., Kronenberg, F.
Publikováno v:
Human Molecular Genetics
Hum. Mol. Genet. 25, 3635-3646 (2016)
Human molecular genetics, vol. 25, no. 16, pp. 3635-3646
Hum. Mol. Genet. 25, 3635-3646 (2016)
Human molecular genetics, vol. 25, no. 16, pp. 3635-3646
Apolipoprotein A-IV (apoA-IV) is a major component of HDL and chylomicron particles and is involved in reverse cholesterol transport. It is an early marker of impaired renal function. We aimed to identify genetic loci associated with apoA-IV concentr
Autor:
Xue, A., Wu, Y., Zhu, Z., Zhang, F., Kemper, K.E., Zheng, Z., Yengo, L., Lloyd-Jones, L.R., Sidorenko, J., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Awadalla, P., Battle, A., Beutner, F., Bonder, M.J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Favé, M.-J., Franke, L., Frayling, T., Gharib, S., Gibson, G., Hemani, G., Jansen, R., Kähönen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Kutalik, Z., Lee, B., Lehtimäki, T., Loeffler, M., Marigorta, U.M., Metspalu, A., Milani, L., Müller-Nurasyid, M., Nauck, M., Nivard, M., Penninx, B., Perola, M., Pervjakova, N., Pierce, B., Powell, J., Prokisch, H., Psaty, B., Raitakari, O., Ring, S., Ripatti, S., Rotzschke, O., Ruëger, S., Saha, A., Scholz, M., Schramm, K., Seppälä, I., Stumvoll, M., Sullivan, P., Teumer, A., Thiery, J., Tong, L., Tönjes, A., van Dongen, J., van Meurs, J., Verlouw, J., Völker, U., Võsa, U., Yaghootkar, H., Zeng, B., McRae, A.F., Visscher, P.M., Zeng, J., Yang, J.
Publikováno v:
eQTLGen Consortium 2018, ' Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes ', Nature Communications, vol. 9, 2941 . https://doi.org/10.1038/s41467-018-04951-w
Nature Communications, 9(1):2941. Nature Publishing Group
Nature Communications
Nature Communications, 9(1):2941. Nature Publishing Group UK
Nat. Commun. 9:2941 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Boomsma, D, Nivard, M G & eQTLGen Consortium 2018, ' Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes ', Nature Communications, vol. 9, no. 1, 2941 . https://doi.org/10.1038/s41467-018-04951-w
eQTLGen Consortium 2018, ' Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes ', Nature Communications, vol. 9, no. 1, 2941 . https://doi.org/10.1038/s41467-018-04951-w
Nature Communications, 9(1):2941. Nature Publishing Group
Nature Communications
Nature Communications, 9(1):2941. Nature Publishing Group UK
Nat. Commun. 9:2941 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Boomsma, D, Nivard, M G & eQTLGen Consortium 2018, ' Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes ', Nature Communications, vol. 9, no. 1, 2941 . https://doi.org/10.1038/s41467-018-04951-w
eQTLGen Consortium 2018, ' Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes ', Nature Communications, vol. 9, no. 1, 2941 . https://doi.org/10.1038/s41467-018-04951-w
Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a40dc452315759bc81da37f76fd9422
https://hdl.handle.net/1983/fa34bfa6-7a44-421c-8f1a-fc5ee0e27bd9
https://hdl.handle.net/1983/fa34bfa6-7a44-421c-8f1a-fc5ee0e27bd9
Autor:
Haworth, S, Shungin, D, van der Tas, JT, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, JR, Lee, MK, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Jessen, LE, Nørrisgaard, PE, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A-M, West, NX, Thomas, SJ, McNeil, DW, Levy, SM, Slayton, R, Nohr, EA, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, ML, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, EB, Franks, PW, Johansson, I, Timpson, NJ
Publikováno v:
Hum. Mol. Genet. 27, 3113-3127 (2018)
Human Molecular Genetics
Haworth, S, Shungin, D, Van Der Tas, J T, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, J R, Lee, M K, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Jessen, L E, Nørrisgaard, P E, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A M, West, N X, Thomas, S J, McNeil, D W, Levy, S M, Slayton, R, Nohr, E A, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, M L, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, E B, Franks, P W, Johansson, I & Timpson, N J 2018, ' Consortium-based genome-wide meta-analysis for childhood dental caries traits ', Human Molecular Genetics, vol. 27, no. 17, pp. 3113-3127 . https://doi.org/10.1093/hmg/ddy237
Human Molecular Genetics, 27, 3113-3127
Haworth, S, Shungin, D, van der Tas, J T, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, J R, Lee, M K, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Jessen, L E, Nørrisgaard, P E, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A-M, West, N X, Thomas, S J, McNeil, D W, Levy, S M, Slayton, R, Nohr, E A, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, M L, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, E B, Franks, P W, Johansson, I & Timpson, N J 2018, ' Consortium-based genome-wide meta-analysis for childhood dental caries traits ', Human Molecular Genetics, vol. 27, no. 17, pp. 3113-3127 . https://doi.org/10.1093/hmg/ddy237
Human Molecular Genetics, 27, 17, pp. 3113-3127
Human Molecular Genetics, 27(17), 3113-3127. Oxford University Press
Haworth, S, Shungin, D, van der Tas, J T, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, J R, Lee, M K, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Eyrich Jessen, L, Nørrisgaard, P E, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A-M, West, N X, Thomas, S J, McNeil, D W, Levy, S M, Slayton, R, Nohr, E A, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, M L, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, E B, Franks, P W, Johansson, I & Timpson, N J 2018, ' Consortium-based genome-wide meta-analysis for childhood dental caries traits ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddy237
Human Molecular Genetics
Haworth, S, Shungin, D, Van Der Tas, J T, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, J R, Lee, M K, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Jessen, L E, Nørrisgaard, P E, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A M, West, N X, Thomas, S J, McNeil, D W, Levy, S M, Slayton, R, Nohr, E A, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, M L, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, E B, Franks, P W, Johansson, I & Timpson, N J 2018, ' Consortium-based genome-wide meta-analysis for childhood dental caries traits ', Human Molecular Genetics, vol. 27, no. 17, pp. 3113-3127 . https://doi.org/10.1093/hmg/ddy237
Human Molecular Genetics, 27, 3113-3127
Haworth, S, Shungin, D, van der Tas, J T, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, J R, Lee, M K, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Jessen, L E, Nørrisgaard, P E, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A-M, West, N X, Thomas, S J, McNeil, D W, Levy, S M, Slayton, R, Nohr, E A, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, M L, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, E B, Franks, P W, Johansson, I & Timpson, N J 2018, ' Consortium-based genome-wide meta-analysis for childhood dental caries traits ', Human Molecular Genetics, vol. 27, no. 17, pp. 3113-3127 . https://doi.org/10.1093/hmg/ddy237
Human Molecular Genetics, 27, 17, pp. 3113-3127
Human Molecular Genetics, 27(17), 3113-3127. Oxford University Press
Haworth, S, Shungin, D, van der Tas, J T, Vucic, S, Medina-Gomez, C, Yakimov, V, Feenstra, B, Shaffer, J R, Lee, M K, Standl, M, Thiering, E, Wang, C, Bønnelykke, K, Waage, J, Eyrich Jessen, L, Nørrisgaard, P E, Joro, R, Seppälä, I, Raitakari, O, Dudding, T, Grgic, O, Ongkosuwito, E, Vierola, A, Eloranta, A-M, West, N X, Thomas, S J, McNeil, D W, Levy, S M, Slayton, R, Nohr, E A, Lehtimäki, T, Lakka, T, Bisgaard, H, Pennell, C, Kühnisch, J, Marazita, M L, Melbye, M, Geller, F, Rivadeneira, F, Wolvius, E B, Franks, P W, Johansson, I & Timpson, N J 2018, ' Consortium-based genome-wide meta-analysis for childhood dental caries traits ', Human Molecular Genetics . https://doi.org/10.1093/hmg/ddy237
Contains fulltext : 200710.pdf (Publisher’s version ) (Open Access) Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce35aa30eb3697d770e4971f5a02c916
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53691
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53691