Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sepideh Khorasanizadeh"'
Autor:
Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, Liyun Zhao, Marie De Borre, Savvas N. Savvides, M. Celeste Simon, Peter Carmeliet, Wolf Reik, Fraydoon Rastinejad, Massimiliano Mazzone, Bernard Thienpont, Diether Lambrechts
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-36 (2020)
Abstract Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcription
Externí odkaz:
https://doaj.org/article/0d2e5621f90946fca225694fec6726cc
Autor:
Maddalena Parafati, R. Jason Kirby, Sepideh Khorasanizadeh, Fraydoon Rastinejad, Siobhan Malany
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stre
Externí odkaz:
https://doaj.org/article/a208db7eeeb9406989c6ccad55d6a5a3
Autor:
Nalini Potluri, Sepideh Khorasanizadeh, Xiaoyu Su, Dalei Wu, Sheng Li, Fraydoon Rastinejad, Stefan Vasile, Jingping Lu, Youngchang Kim, Xiaotong Diao, Becky Hood
Publikováno v:
Nature chemical biology
Hypoxia-inducible factor-2 (HIF-2) is a heterodimeric transcription factor formed through dimerization between an oxygen-sensitive subunit HIF-2α subunit and its obligate partner subunit ARNT. Enhanced HIF-2 activity drives some cancers, while reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4a7d502ae8b5287b73a35c804f0a1c
http://europepmc.org/articles/PMC6447045
http://europepmc.org/articles/PMC6447045
Autor:
Luc Schoonjans, Sepideh Khorasanizadeh, Marie De Borre, Hui Zhao, Ricardo Amorim, M. Celeste Simon, Flora D’Anna, Peter Carmeliet, Jieyi Xiong, Laurien Van Dyck, Pawel Bieniasz-Krzywiec, Massimiliano Mazzone, Diether Lambrechts, Junbin Qian, Vikas Chandra, Savvas N. Savvides, Rebecca V. Berrens, Qian Yu, Liyun Zhao, Julie De Smedt, Jason Matthews, Bernard Thienpont, Liesbeth Minnoye, Fraydoon Rastinejad, Wolf Reik
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-36 (2020)
GENOME BIOLOGY
Genome Biology
GENOME BIOLOGY
Genome Biology
Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcriptional respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c714d214bd7aba5782fbda0d63cb6fc3
https://www.repository.cam.ac.uk/handle/1810/325954
https://www.repository.cam.ac.uk/handle/1810/325954
Nuclear receptors (NRs) are master regulators of broad genetic programs in metazoans. These programs are regulated in part by the small-molecule ligands that bind NRs and modulate their interactions with transcriptional coregulatory factors. X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fd3c1c75ef5dad69b52894f3ed4f27
https://doi.org/10.1210/en.2016-1559
https://doi.org/10.1210/en.2016-1559
Autor:
Sepideh Khorasanizadeh, Maddalena Parafati, Siobhan Malany, R. Jason Kirby, Fraydoon Rastinejad
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9eab5f9e918b4601d9d3623fcb7822b
http://europepmc.org/articles/PMC6176998
http://europepmc.org/articles/PMC6176998
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1839:686-693
Background Lysine methylation is the most versatile covalent posttranslational modification (PTM) found in histones and non-histone proteins. Over the past decade a number of methyllysine-specific readers have been discovered and their interactions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c676d050f22fd0ed989ff2043ef811f7
https://doi.org/10.1016/j.bbagrm.2014.04.001
https://doi.org/10.1016/j.bbagrm.2014.04.001
Publikováno v:
Journal of Molecular Endocrinology. 51:T1-T21
Nuclear receptors (NRs) are a major transcription factor family whose members selectively bind small-molecule lipophilic ligands and transduce those signals into specific changes in gene programs. For over two decades, structural biology efforts were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663b61de716f90ee08b1ff49cbf04aba
https://doi.org/10.1530/jme-13-0173
https://doi.org/10.1530/jme-13-0173
Autor:
Sepideh Khorasanizadeh, Jun Ding, Ryan M. Esquejo, Katalin Sandor, Manuel Roqueta-Rivera, Peter E. Phelan, Bence Daniel, Xiaoman Li, Timothy F. Osborne, Fabienne Foufelle
Transcriptional and chromatin regulations mediate the liver response to nutrient availability. The role of chromatin factors involved in hormonal regulation in response to fasting is not fully understood. We have identified SETDB2, a glucocorticoid-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba4e877075e9af081e81974ababca29
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 46:507-526
The chromatin organization modifier domain (chromodomain) was first identified as a motif associated with chromatin silencing in Drosophila. There is growing evidence that chromodomains are evolutionary conserved across different eukaryotic species t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42b5be7533c3087fbf35bdde73666f
https://doi.org/10.3109/10409238.2011.619164
https://doi.org/10.3109/10409238.2011.619164