The mIAA7 degron improves auxin-mediated degradation in Caenorhabditis elegans.

Autor: Sepers, Jorian J.¹, Verstappen, Noud H. M.¹, Vo, An A.², Ragle, James Matthew², Ruijtenberg, Suzan¹, Ward, Jordan D.², Boxem, Mike¹ m.boxem@uu.nl

Publikováno v: G3: Genes | Genomes | Genetics. Oct2022, Vol. 12 Issue 10, p1-15. 15p.

The mIAA7 degron improves auxin-mediated degradation in Caenorhabditiselegans

Autor: Sepers, Jorian J, Verstappen, Noud HM, Vo, An A, Ragle, James Matthew, Ruijtenberg, Suzan, Ward, Jordan D, Boxem, Mike

Publikováno v: G3 (Bethesda, Md.), vol 12, iss 10

Auxin-inducible degradation is a powerful tool for the targeted degradation of proteins with spatiotemporal control. One limitation of the auxin-inducible degradation system is that not all proteins are degraded efficiently. Here, we demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8d795250f77ddfb9441663001b6f1de7
https://escholarship.org/uc/item/3xk0g1j8

C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during Caenorhabditiselegans development

Autor: Ramalho, João J, Sepers, Jorian J, Nicolle, Ophélie, Schmidt, Ruben, Cravo, Janine, Michaux, Grégoire, Boxem, Mike, Sub Developmental Biology, Developmental Biology

Publikováno v: Development (Cambridge), 147(14)
Development (Cambridge, England), 147(14). Company of Biologists Ltd
Development (Cambridge, England)
Development (Cambridge, England), 2020, 147 (14), pp.dev188011. ⟨10.1242/dev.188011⟩
Development (Cambridge, England), Company of Biologists, 2020, 147 (14), pp.dev188011. ⟨10.1242/dev.188011⟩
Development (Cambridge) 147 (2020) 14

International audience; ERM proteins are conserved regulators of cortical membrane specialization, that function as membrane-actin linkers and molecular hubs. Activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbfb1de453749214bc07ed4764a3acc
https://doi.org/10.1242/dev.188011