Výsledky vyhledávání - "Sepehr Rokhsar"

A phase 1 study of veliparib, a PARP-1/2 inhibitor, with gemcitabine and radiotherapy in locally advanced pancreatic cancer

Publikováno v: EBioMedicine

Background Locally advanced pancreatic cancer (LAPC) has a dismal prognosis with current treatment modalities and one-third of patients die from local progression of disease. Preclinical studies with orthotopic PC demonstrated dramatic synergy betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cb37da95b29e9ac78e4d6099c921c3
https://doi.org/10.1016/j.ebiom.2018.12.060

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TEG-Platelet Mapping-Guided Evaluation of Anti-Phospholipid Carrier with Unusual Clinical Presentation and Paradoxical Laboratory Findings

Autor: Oksana Volod, Sepehr Rokhsar, Yao Ma

Publikováno v: Hematology & Transfusion International Journal. 2

Anti-phospholipid syndrome is defined by the combination of clinical thrombosis and detection of persistent anti-phospholipid antibodies (aPL), including lupus anti-coagulant (LA). Those who do not meet full clinical criteria of overt thrombosis but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38eff13229c7d2fc43f60f653b4ac73e
https://doi.org/10.15406/htij.2016.02.00027

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Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas

Autor: Fred P. Rosenfelt, Melissa Cervania, Sepehr Rokhsar, Andy Pao, Bekir Cinar, Jean Lopategui, Raju Pillai, Serhan Alkan, Munevver Cinar

Publikováno v: Leukemia research. 39(7)

Double hit lymphoma or triple hit lymphoma (DHL/THL) is a rare form of aggressive B-Cell Lymphoma. Overexpression of MYC, BCL2 or/and BCL6 due to genomic rearrangements are the key molecular features of DHL/THL. Patients with DHL/THL show very aggres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33ce229813f753fc9e5c7098fe3502a
https://pubmed.ncbi.nlm.nih.gov/25916698

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Intestinal stoma complications in immunocompromised children

Autor: Elizabeth A. Harrison, Donald B. Shaul, J.Duncan Phillips, Sepehr Rokhsar

Publikováno v: Journal of Pediatric Surgery. 34:1757-1761

Background/Purpose: When performing an urgent gastrointestinal operation on an immunocompromised child, the pediatric surgeon may have to decide between performing an intestinal anastomosis (and risk leakage or sepsis) or creating an intestinal stoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8757281b5a629c9913b29c7191d4366
https://doi.org/10.1016/s0022-3468(99)90306-8

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Long-term survival of patients with coronary artery disease and left ventricular dysfunction: Implications for the role of myocardial viability assessment in management decisions

Autor: Jamshid Maddahi, Marcelo F. Di Carli, Heinrich R. Schelbert, Sepehr Rokhsar, Daniela Bianco-Batlles, Barbara Fromm, Richard C. Brunken

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 116(6):997-1004

Objectives: Our purpose was to evaluate the long-term benefit of myocardial viability assessment for stratifying risk and selecting patients with low ejection fraction for coronary artery bypass grafting and to determine the relation between the seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaef2a13ab88917c6406621e3355f80

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Phase I study of veliparib with gemcitabine and radiation therapy in patients with borderline resectable and locally advanced unresectable pancreatic cancer

Autor: Sepehr Rokhsar, Nicholas N. Nissen, Simon S. Lo, Mourad Tighiouart, Andrew Eugene Hendifar, Alagappan Annamalai, David M. J. Hoffman, Kevin S. Scher, Laith H. Jamil, Andre Rogatko, Richard Tuli, Miranda Bryant

Publikováno v: Journal of Clinical Oncology. 34:TPS487-TPS487

TPS487 Background: Targeted inhibition of PARP1/2 is one way to further exploit the well-known synergy between gemcitabine (G) and radiotherapy (RT) in locally advanced pancreatic cancer (LAPC). PARP1/2 inhibitors, such as veliparib (V), have shown e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::535d6020a30e12e8ce7cf4f1b65acbdf
https://doi.org/10.1200/jco.2016.34.4_suppl.tps487

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Relation of myocardial perfusion at rest and during pharmacologic stress to the PET patterns of tissue viability in patients with severe left ventricular dysfunction

Autor: Jamshid Maddahi, Farbod Asgarzadie, Heinrich R. Schelbert, Richard C. Brunken, Marcelo F. Di Carli, Sepehr Rokhsar

Publikováno v: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 5(6)

Stress perfusion imaging can assess effectively the amount of jeopardized myocardium, but its use for identifying underperfused but viable myocardium has yielded variable results. We evaluated the relation between measurements of myocardial perfusion

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https://pubmed.ncbi.nlm.nih.gov/9869486

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Risk factors for early infection of central venous catheters in pediatric patients

Autor: Sepehr Rokhsar, Wilbert H. Mason, Donald B. Shaul, Marcio H. Malogolowkin, Linda S. Chan, Bryan Scheer, Beth A Boody, Valerie A Jones

Publikováno v: Journal of the American College of Surgeons. 186(6)

In an effort to avoid infections that can lead to the premature removal of indwelling central venous catheters (CVCs), the surgical technique and host factors present in pediatric recipients of permanent CVCs were reviewed.All patients receiving CVCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cb825a097c92001731df4fc0fd0e95
https://pubmed.ncbi.nlm.nih.gov/9632153

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