Cell-penetrating TLR inhibitor peptide alleviates ulcerative colitis by the functional modulation of macrophages

Autor: Bikash Thapa, Seongwon Pak, Dohyeon Chung, Hye Kyoung Shin, Seong Ho Lee, Keunwook Lee

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Toll-like receptors (TLRs) have a crucial role not only in triggering innate responses against microbes but in orchestrating an appropriate adaptive immunity. However, deregulated activation of TLR signaling leads to chronic inflammatory conditions s

Externí odkaz: https://doaj.org/article/c21c4904b6ad4038a0c5a000dcd25cbf

Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions

Autor: Hyun Jin Jung, Ju-Hee Kang, Seongwon Pak, Keunwook Lee, Je Kyung Seong, Seung Hyun Oh

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 2, p 614 (2020)

Nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a cell-surface adhesion molecule that regulates cell migration and attachment. This study demonstrates the increase in Ninj1 protein expression during development of intestinal inflammation. Ninj1-

Externí odkaz: https://doaj.org/article/00739a6e8cf04b61a5161ede370d96a3

CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages

Autor: Hyunsub Sim, Hyung-Joo Kwon, Daecheol Jeong, Hye-In Kim, Bikash Thapa, Keunwook Lee, Seongwon Pak

Publikováno v: Immune Network. 21

Macrophages are important for the first line of defense against microbial pathogens. Integrin CD11b, which is encoded by Itgam, is expressed on the surface of macrophages and has been implicated in adhesion, migration, and cell-mediated cytotoxicity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aea0f9f1ea0a1a4997378d180981f29f
https://doi.org/10.4110/in.2021.21.e13

Decursinol Angelate Mitigates Sepsis Induced by Methicillin-Resistant Staphylococcus aureus Infection by Modulating the Inflammatory Responses of Macrophages

Autor: Bikash Thapa, Keunwook Lee, Seongwon Pak

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10950, p 10950 (2021)

The herbal plant Angelica gigas (A. gigas) has been used in traditional medicine in East Asian countries, and its chemical components are reported to have many pharmacological effects. In this study, we showed that a bioactive ingredient of A. gigas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a29d3e962c04436ca159c70e6891195
https://doi.org/10.3390/ijms222010950

Erratum to 'Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses' [Biomol. Ther. 27 (2019) 466-473]

Autor: Bikash Thapa, Keunwook Lee, Hyung-Joo Kwon, Seongwon Pak

Publikováno v: Biomolecules & Therapeutics

Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of the herbal plant and the effect on T cell res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fff92b3ef4c643c40fcf3b7e63586e
https://doi.org/10.4062/biomolther.2019.221