Targeted next-generation sequencing at copy-number breakpoints for personalized analysis of rearranged ends in solid tumors.

Autor: Hyun-Kyoung Kim, Won Cheol Park, Kwang Man Lee, Hai-Li Hwang, Seong-Yeol Park, Sungbin Sorn, Vishal Chandra, Kwang Gi Kim, Woong-Bae Yoon, Joon Seol Bae, Hyoung Doo Shin, Jong-Yeon Shin, Ju-Young Seoh, Jong-Il Kim, Kyeong-Man Hong

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100089 (2014)

BACKGROUND: The concept of the utilization of rearranged ends for development of personalized biomarkers has attracted much attention owing to its clinical applicability. Although targeted next-generation sequencing (NGS) for recurrent rearrangements

Externí odkaz: https://doaj.org/article/894c19448b494c81b9cc3beda0c3fd0a

Phthalate Plasticizers in Children’s Products and Estimation of Exposure: Importance of Migration Rate

Autor: Dana Fahad Mohamed Salman Mohamed, Jeong Won An, Sa Ho Chun, Du Yung Kim, Da Young Kang, Hae Soo Kim, Seong Yeol Park, Hyun Wook Kwon, Yerin Jung, Jung Hwan Kwon

Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 8582, p 8582 (2020)
International Journal of Environmental Research and Public Health
Volume 17
Issue 22

Plasticizers are added to diverse consumer products including children’s products. Owing to their potential for endocrine disruption, the use of phthalate plasticizers is restricted in many children’s products. In this study, exposure to five pht

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0892879c0e3ce130e133872b57a0c0a
https://www.mdpi.com/1660-4601/17/22/8582

Inactivation of the FoxO3a transcription factor is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated senescence in human colon cancer and breast cancer cells

Autor: Young-Seuk Bae, Seong-Yeol Park

Publikováno v: Biochemical and Biophysical Research Communications. 478:18-24

We previously showed that protein kinase CK2 downregulation mediates senescence through the reactive oxygen species (ROS)-p53-p21(Cip1/WAF1) pathway in various human cells. In the present study, we investigated whether the FoxO3a transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcf9767730361504fa03c52b965a691
https://doi.org/10.1016/j.bbrc.2016.07.106

Expression of TMBIM6 in Cancers: The Involvement of Sp1 and PKC

Autor: Jae Won Soh, Raghu Patil Junjappa, Hyun-Kyoung Kim, Seong-Yeol Park, Kashi Raj Bhattarai, Hyung-Ryong Kim, Han-Jung Chae, Kyung-Woon Kim

Publikováno v: Cancers
Volume 11
Issue 7
Cancers, Vol 11, Iss 7, p 974 (2019)

Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) is upregulated in several cancer types and involved in the metastasis. Specific downregulation of TMBIM6 results in cancer cell death. However, the TMBIM6 gene transcriptional regulation in norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cdeac7b9f0747745c347fda8e4711c
https://doi.org/10.3390/cancers11070974

Immunohistochemical localization of LLC1 in human tissues and its limited expression in non-small cell lung cancer

Autor: Vishal, Chandra, Yong-Bock, Choi, Hai-Li, Hwang, Jeong-Hwa, Lee, Seong-Yeol, Park, Hyun-Kyoung, Kim, Shiv, Poojan, Jae-Soo, Koh, Han-Seong, Kim, Kyeong-Man, Hong

Publikováno v: Histology and histopathology. 30(9)

We have shown both LLC1 expression in the lung epithelium by in situ hybridization and its inactivation in lung cancer by epigenetic modification. However, LLC1 protein's cellular localization or its role in normal lung or cancer tissues has not yet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d61e5752ad42218054d1989b648372a8
https://pubmed.ncbi.nlm.nih.gov/25786037