Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Seong Joo Koo"'
Autor:
Maria Jäpel, Fabian Gerth, Takeshi Sakaba, Jelena Bacetic, Lijun Yao, Seong-Joo Koo, Tanja Maritzen, Christian Freund, Volker Haucke
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 409-420.e6 (2020)
Summary: The rapid replenishment of release-ready synaptic vesicles (SVs) at a limiting number of presynaptic release sites is required to sustain high-frequency neurotransmission in CNS neurons. Failure to clear release sites from previously exocyto
Externí odkaz:
https://doaj.org/article/6bb6940910be4bb98a685cfb307b97e0
Autor:
Stefan G. Kathman, Seong Joo Koo, Garrett L. Lindsey, Hsuan-Lin Her, Steven M. Blue, Haoxin Li, Steffen Jaensch, Jarrett R. Remsberg, Kay Ahn, Gene W. Yeo, Brahma Ghosh, Benjamin F. Cravatt
Publikováno v:
Nature Chemical Biology.
Autor:
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, Brahma Ghosh, Omar Abdel-Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, Gene W. Yeo, Benjamin F. Cravatt
SummaryMost human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such “binding-first” assays affect protein function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f22999c7fd8b3058ebc700cdfeab3
https://doi.org/10.1101/2022.12.12.520090
https://doi.org/10.1101/2022.12.12.520090
Autor:
Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar
Publikováno v:
Cancer Research. 82:2133-2133
Appropriate control of cell death is a fundamental biological process which is frequently dysregulated during tumor development and therapeutic resistance. Apoptosis is a form of regulated cell death initiated by either the extracellular environment
Autor:
Laure Cougnaud, Hugo Ceulemans, Seong Joo Koo, Jelle Van de Waeter, Jean-Marc Neefs, Emmanuel Gustin, Jörg K. Wegner, Hinrich W. H. Göhlmann, Margino Steemans, Ilse Van den Wyngaert, Michael J. Cox, Soulaiman Benalla, Steffen Jaensch, Pieter J. Peeters, Yolanda T. Chong, Daan Seynaeve, Dmitry Malkov, Mart Bittremieux
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Phenomic profiles are high-dimensional sets of readouts that can comprehensively capture the biological impact of chemical and genetic perturbations in cellular assay systems. Phenomic profiling of compound libraries can be used for compound target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ad9da8d1ef2e11a2c7e73ab2912140
Autor:
Volker Haucke, Dmytro Puchkov, Georgi Tadeus, Tanja Maritzen, Christian Rosenmund, Martin Lehmann, Niclas Gimber, Gaga Kochlamazashvili, Benjamin R. Rost, Jan Schmoranzer, Seong Joo Koo
Publikováno v:
Neuron. 88(2):330-344
SummaryNeurotransmission depends on synaptic vesicle (SV) exocytosis driven by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex formation of vesicular synaptobrevin/VAMP2 (Syb2). Exocytic fusion is followed by end
Autor:
John W. Cuozzo, Matthew A. Clark, Holly H. Soutter, Ying Zhang, Anthony D. Keefe, Vera Puetter, Hilmar Weinmann, Ingo Hartung, Detlef Stöckigt, Seong Joo Koo, Eric A. Sigel, Paolo A. Centrella, Oleg Fedorov, Simon Holton, Christoph E. Dumelin, Kilian Huber, Dawn M. Troast, Antonius Ter Laak, L. Diaz-Saez, Jan Hübner, Mátyás Gorjánácz, Volker Badock, Apirat Chaikuad, Markus Berger, Benno Kuropka, Vincent Rodeschini, James M. Bennett, Amaury Ernesto Fernandez-Montalvan, Didier M. Roche, Joerg Weiske
ATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose overexpression has been linked to the progress of various cancer types. Here, we report a DNA-encoded library screen leading to the discovery of BAY-850, a potent and isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e59468d78b543d20e7ca9d3032de5
https://europepmc.org/articles/PMC6218015/
https://europepmc.org/articles/PMC6218015/
Autor:
Mátyás Gorjánácz, Volker Badock, Seong Joo Koo, Sarah Vittori, James E. Bradner, Simon Holton, Christopher J. Ott, Joern Toedling, Oliver von Ahsen, Amaury Ernesto Fernandez-Montalvan
Publikováno v:
Oncotarget
// Seong Joo Koo 1 , Amaury E. Fernandez-Montalvan 1 , Volker Badock 1 , Christopher J. Ott 2, 3, 4 , Simon J. Holton 1 , Oliver von Ahsen 1 , Joern Toedling 1 , Sarah Vittori 2, 3 , James E. Bradner 2, 3, 4, 5 , Matyas Gorjanacz 1 1 Drug Discovery,
Publikováno v:
Cellular Logistics. Jul/Aug2011, Vol. 1 Issue 4, p168-172. 5p.
Autor:
Tanja Maritzen, Stefan Markovic, Volker Haucke, Jens Dernedde, Figen Beceren-Braun, Dmytro Puchkov, Hartmut Oschkinat, Carsten C. Mahrenholz, Seong Joo Koo, Rudolf Volkmer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 108(33): 13540-13545
Neurotransmission depends on the exo-endocytosis of synaptic vesicles at active zones. Synaptobrevin 2 [also known as vesicle-associated membrane protein 2 (VAMP2)], the most abundant synaptic vesicle protein and a major soluble NSF attachment protei