Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Seong Hun Lim"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1479-1487 (2024)
Abstract The development of chemoresistance is a major challenge in the treatment of several types of cancers in clinical settings. Stemness and chemoresistance are the chief causes of poor clinical outcomes. In this context, we hypothesized that und
Externí odkaz:
https://doaj.org/article/aa59870d805f441cab50ddaf79adce47
Autor:
Won Chan, Hwang, Doona, Song, Hyesung, Lee, Changmok, Oh, Seong Hun, Lim, Hyeon Jeong, Bae, Nam Doo, Kim, Gyoonhee, Han, Do Sik, Min
Publikováno v:
Experimental & Molecular Medicine. 54:1563-1576
Phospholipase D (PLD) is a potential therapeutic target against cancer. However, the contribution of PLD inhibition to the antitumor response remains unknown. We developed a potent and selective PLD1 inhibitor based on computer-aided drug design. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dce24ea0eb52c551ebf0430697d0f8d
https://doi.org/10.1038/s12276-022-00853-6
https://doi.org/10.1038/s12276-022-00853-6
Publikováno v:
Experimental & Molecular Medicine
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase that plays diverse physiological roles. However, little is known about the regulation of SIRT1 activity. Here, we show that phospholipase D2 (PLD2), but not PLD1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af85d0377dde57ef7822892f6c4b1334
https://doi.org/10.1038/s12276-021-00659-y
https://doi.org/10.1038/s12276-021-00659-y