Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Seong Rim Byeon"'
Autor:
Sun Jun Park, Hyeon Jeong Kim, Yong Sup Lee, Eunji Cheong, Ki Duk Park, Jong Hyun Park, Ae Nim Pae, Jiwon Choi, Bo Ko Jang, Seong Rim Byeon
Publikováno v:
European Journal of Medicinal Chemistry. 185:111777
Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been repor
Autor:
Han Bok Kwak, Sung-Hee Pi, Hyung-Keun You, Yongcheng Ying, Seong Hwan Kim, Su-Ui Lee, Jiyong Hong, Seong Rim Byeon, Hendrik Luesch
Publikováno v:
ACS Medicinal Chemistry Letters. 2:248-251
Due to their capability of modifying chromatin structure and thereby regulating gene transcription, histone deacetylases (HDACs) have been reported to play important roles in osteogenesis and considered a promising potential therapeutic target for bo
Publikováno v:
Organic Letters. 10:4021-4024
To characterize largazole's structural requirements for histone deacetylase (HDAC) inhibitory and antiproliferative activities, a series of analogues with modifications to the side chain or 16-membered macrocycle were prepared and biologically evalua
Autor:
Bong Young Chung, Ji Hoon Lee, Kyung Ho Yoo, Seung Jun Oh, Seong Rim Byeon, Soo Jeong Lim, Dong Jin Kim, Dae Hyuk Moon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1534-1537
This paper describes a novel series of stilbenylbenzoxazole (SBO) and stilbenylbenzothiazole (SBT) derivatives for beta-amyloid specific binding probes. These 24 compounds were synthesized and evaluated by competitive binding assay against beta-amylo
Autor:
Yun Jung Jin, Ji Hoon Lee, Dong Jin Kim, Soo Jeong Lim, Kyung Ho Yoo, Seong Rim Byeon, Kye Jung Shin, Seung Jun Oh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4022-4025
New ferulic acid and benzothiazole dimer derivatives were synthesized and evaluated by in vitro competition assay using [(125)I]TZDM for their specific binding affinities to Abeta fibrils. In particular, 4a showed the most excellent binding affinity
Publikováno v:
Tetrahedron Letters. 52:2468-2470
Due to the high reactivity of the formyl group under either basic or acidic reaction conditions required for the direct generation of aldehyde enolates, intramolecular Michael additions of aldehyde enolates to α,β-unsaturated carbonyl compounds hav
Autor:
Maeng Sup Kim, Seong Rim Byeon, Jae Yang Kong, Young Gil Ahn, Hyun-Jin Kim, Dong-Jin Kim, Young-Soo Kim, Jeon Mijin, Hye Yun Kim
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(11)
Alzheimer’s disease drug discovery regarding exploration into the molecules and processes has focused on the intrinsic causes of the brain disorder correlated with the accumulation of amyloid-β. An anti-amyloidogenic bis-styrylbenzene derivative,
Publikováno v:
Organic letters. 13(21)
The total synthesis of psymberin was achieved employing a readily available chiral epoxide to prepare two of the three subunits in the natural product. The key reaction was a highly stereoselective organocatalytic oxa-conjugate addition reaction of
Publikováno v:
ChemInform. 42
Due to the high reactivity of the formyl group under either basic or acidic reaction conditions required for the direct generation of aldehyde enolates, intramolecular Michael additions of aldehyde enolates to α,β-unsaturated carbonyl compounds hav
Autor:
Young-Soo Kim, Young Hoon Kim, Hana Hwang, Dong Jin Kim, Maeng Sup Kim, Gwan Sun Lee, Seong Rim Byeon, HyeYun Kim, Inhee Mook-Jung, Young-Gil Ahn, Jeiwon Cho, Ji Hoon Lee
Publikováno v:
Alzheimer's & Dementia. 6